Topical menthol for chemotherapy-induced peripheral neuropathy: a randomised controlled trial in breast cancer.

IF 2 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI:10.1136/spcare-2023-004483

Deniz Ozdemir, Selda Arslan, Mehmet Artac, Fatih Karaarslan

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Abstract

Objectives: Chemotherapy-induced peripheral neuropathy (CIPN) symptom is one of the side effects of paclitaxel in breast cancer patients. This randomised controlled study was conducted to investigate the effect of topical menthol applied on the hands and feet of breast cancer patients receiving chemotherapy on CIPN symptoms.

Methods: 60 breast cancer patients receiving chemotherapy were randomly assigned to an intervention group (n=30), which received topical menthol treatment, or a control group (n=30), which received standard care. Both groups continued their routine pharmacological treatments throughout the study. The intervention group applied 1% menthol topically to their hands and feet two times a day. The effect of the intervention on CIPN symptoms was evaluated 3 weeks and 6 weeks after the intervention.

Results: The intervention group showed a significantly greater improvement in CIPN symptoms over time compared with the control group, with an effect size of η²=0.214 for the group×time interaction. Additionally, the intervention group exhibited a notable positive change in the exposure subscale of the CIPN rating scale, with an effect size of η²=0.114.

Conclusions: Topical application of menthol significantly mitigates the symptoms of CIPN in breast cancer patients. This study supports the use of menthol as an effective adjunctive treatment for CIPN.

Trial registration number: NCT05429814.

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外用薄荷醇治疗化疗引起的周围神经病变：乳腺癌随机对照试验。

研究目的化疗诱发的周围神经病变（CIPN）症状是乳腺癌患者服用紫杉醇的副作用之一。本随机对照研究旨在探讨在接受化疗的乳腺癌患者手脚上外敷薄荷醇对 CIPN 症状的影响。方法：将 60 名接受化疗的乳腺癌患者随机分配到接受外敷薄荷醇治疗的干预组（30 人）和接受标准护理的对照组（30 人）。在整个研究过程中，两组患者都继续接受常规药物治疗。干预组在手脚上局部涂抹 1%的薄荷醇，每天两次。干预3周和6周后，评估干预对CIPN症状的影响：结果：随着时间的推移，干预组的 CIPN 症状改善程度明显高于对照组，组与时间交互作用的效应大小为 η2=0.214 。此外，干预组在 CIPN 评定量表的暴露分量表中表现出明显的积极变化，效应大小为 η2=0.114 ：局部使用薄荷醇能明显减轻乳腺癌患者的 CIPN 症状。这项研究支持使用薄荷醇作为 CIPN 的有效辅助治疗：NCT05429814.

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来源期刊

BMJ Supportive & Palliative Care Medicine-Medicine (miscellaneous)

CiteScore

4.60

自引率

7.40%

发文量

170

期刊介绍： Published quarterly in print and continuously online, BMJ Supportive & Palliative Care aims to connect many disciplines and specialties throughout the world by providing high quality, clinically relevant research, reviews, comment, information and news of international importance. We hold an inclusive view of supportive and palliative care research and we are able to call on expertise to critique the whole range of methodologies within the subject, including those working in transitional research, clinical trials, epidemiology, behavioural sciences, ethics and health service research. Articles with relevance to clinical practice and clinical service development will be considered for publication. In an international context, many different categories of clinician and healthcare workers do clinical work associated with palliative medicine, specialist or generalist palliative care, supportive care, psychosocial-oncology and end of life care. We wish to engage many specialties, not only those traditionally associated with supportive and palliative care. We hope to extend the readership to doctors, nurses, other healthcare workers and researchers in medical and surgical specialties, including but not limited to cardiology, gastroenterology, geriatrics, neurology, oncology, paediatrics, primary care, psychiatry, psychology, renal medicine, respiratory medicine.