Periodontitis and Chronic Obstructive Pulmonary Disease: A bidirectional Mendelian randomization study.

IF 0.9 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Community dental health Pub Date : 2024-08-30 DOI:10.1922/CDH_00036Chen06

M Chen, S Chang, Y Xu, L Zhang, H Guo, J Liu

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Abstract

Objective: Observational studies have suggested an association between chronic periodontitis (CP) and chronic obstructive pulmonary disease (COPD). This study aimed to determine whether there is a causal relationship between CP and COPD incidence.

Design: Two‑sample Mendelian Randomization (MR) analysis using summary statistics from two genome‑wide association studies (GWASs) of European ancestry. Single nucleotide polymorphisms (SNPs) associated with COPD were obtained from the FinnGen database, which included 16,380,382 SNPs. The diagnosis of COPD was based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD 2023). We also obtained SNPs associated with CP from the FinnGen database, which included 16,380,378 SNPs.

Results: Sixteen eligible SNPs were extracted to analyze the causal effect of CP on COPD incidence. There was no causal correlation between CP and COPD using the inverse variance-weighted method (IVW) (OR=0.97, 95%CI= 0.91-1.05; p=0.482). Seven eligible SNPs were extracted to analyze the causal effect of COPD on CP incidence. Again, there was also no causal correlation between using IVW (OR=1.09, 95%CI=0.93-1.28; p=0.279).

Conclusion: We did not demonstrate a causal relationship between genetically predicted CP and COPD, or between genetically predicted COPD and CP.

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牙周炎与慢性阻塞性肺病：一项双向孟德尔随机研究

目的：观察性研究表明，慢性牙周炎（CP）与慢性阻塞性肺疾病（COPD）之间存在关联。本研究旨在确定慢性牙周炎与慢性阻塞性肺病发病率之间是否存在因果关系：设计：使用两项欧洲血统全基因组关联研究（GWAS）的汇总统计数据进行双样本孟德尔随机化（MR）分析。与慢性阻塞性肺病相关的单核苷酸多态性（SNPs）来自芬兰基因数据库，其中包括16,380,382个SNPs。慢性阻塞性肺病的诊断依据是全球慢性阻塞性肺病倡议（GOLD 2023）。我们还从FinnGen数据库中获得了与慢性阻塞性肺病相关的SNPs，其中包括16,380,378个SNPs：结果：我们提取了 16 个符合条件的 SNPs，以分析 CP 对慢性阻塞性肺病发病率的因果效应。采用逆方差加权法（IVW），CP 与慢性阻塞性肺病之间不存在因果关系（OR=0.97，95%CI= 0.91-1.05；P=0.482）。提取了 7 个符合条件的 SNPs，以分析慢性阻塞性肺病对慢性阻塞性肺病发病率的因果效应。同样，使用 IVW 之间也没有因果关系（OR=1.09，95%CI=0.93-1.28；P=0.279）：我们没有证明遗传预测的慢性阻塞性肺病与慢性阻塞性肺病之间或遗传预测的慢性阻塞性肺病与慢性阻塞性肺病之间存在因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Community dental health 医学-牙科与口腔外科

CiteScore

2.20

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is concerned with dental public health and related subjects. Dental public health is the science and the art of preventing oral disease, promoting oral health, and improving the quality of life through the organised efforts of society. The discipline covers a wide range and includes such topics as: -oral epidemiology- oral health services research- preventive dentistry - especially in relation to communities- oral health education and promotion- clinical research - with particular emphasis on the care of special groups- behavioural sciences related to dentistry- decision theory- quality of life- risk analysis- ethics and oral health economics- quality assessment. The journal publishes scientific articles on the relevant fields, review articles, discussion papers, news items, and editorials. It is of interest to dentists working in dental public health and to other professionals concerned with disease prevention, health service planning, and health promotion throughout the world. In the case of epidemiology of oral diseases the Journal prioritises national studies unless local studies have major methodological innovations or information of particular interest.