The biomolecule corona mediates pulmonary delivery of nanomedicine

IF 4.4 2区医学 Q1 PHARMACOLOGY & PHARMACY European Journal of Pharmaceutics and Biopharmaceutics Pub Date : 2024-07-20 DOI:10.1016/j.ejpb.2024.114420

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Abstract

Pulmonary delivery of therapeutics (e.g., biologics, antibiotics, and chemotherapies) encapsulated in nanoparticles is desirable for the ability to provide a localised treatment, bypassing the harsh gastrointestinal environment. However, limited understanding of the biological fate of nanoparticles upon administration to the lungs hinders translation of pre-clinical investigations into viable therapies. A key knowledge gap is the impact of the pulmonary biomolecular corona on the functionality of nanoparticles. In this review, opportunities and challenges associated with pulmonary nanoparticle delivery are elucidated, highlighting the impact of the pulmonary biomolecular corona on immune recognition and nanoparticle internalisation in target cells. Recent investigations detailing the influence of proteins, lipids and mucin derived from pulmonary surfactants on nanoparticle behaviour are detailed. In addition, latest approaches in modulating plasma protein corona upon systemic delivery for biodistribution to the lungs are also discussed. Key examples of reengineering nanoparticle structure to mediate formation of biomolecule corona are provided. This review aims to provide a comprehensive understanding on biomolecular corona of nanoparticles for pulmonary delivery, while accentuating their significance for successful translation of newly investigated therapeutics.

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生物分子电晕介导纳米药物的肺输送。

将封装在纳米颗粒中的治疗药物（如生物制剂、抗生素和化疗药物）送入肺部，能够绕过恶劣的胃肠道环境，提供局部治疗，这一点非常理想。然而，由于对纳米颗粒进入肺部后的生物学命运了解有限，临床前研究无法转化为可行的疗法。一个关键的知识缺口是肺部生物分子电晕对纳米粒子功能的影响。本综述阐明了与肺部纳米颗粒给药相关的机遇和挑战，强调了肺部生物分子冠对免疫识别和纳米颗粒在靶细胞内化的影响。详细介绍了从肺表面活性物质中提取的蛋白质、脂类和粘蛋白对纳米粒子行为影响的最新研究。此外，还讨论了在全身给药时调节血浆蛋白电晕以实现肺部生物分布的最新方法。文中还提供了重新设计纳米粒子结构以介导生物分子电晕形成的主要实例。本综述旨在提供对用于肺部给药的纳米颗粒生物分子电晕的全面了解，同时强调其对新研究疗法成功转化的重要意义。

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来源期刊

European Journal of Pharmaceutics and Biopharmaceutics 医学-药学

CiteScore

8.80

自引率

4.10%

发文量

211

审稿时长

36 days

期刊介绍： The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics. Topics covered include for example: Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids) Aspects of manufacturing process design Biomedical aspects of drug product design Strategies and formulations for controlled drug transport across biological barriers Physicochemical aspects of drug product development Novel excipients for drug product design Drug delivery and controlled release systems for systemic and local applications Nanomaterials for therapeutic and diagnostic purposes Advanced therapy medicinal products Medical devices supporting a distinct pharmacological effect.