{"title":"Flavonoid Supplementation Is Beneficial for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.","authors":"Yiting Jiang, Weihuan Hu, Hanyue Zhu, Chang Liu, Fan Qu, Jue Zhou","doi":"10.1093/nutrit/nuae101","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Polycystic ovary syndrome (PCOS) is a prevalent hormonal imbalance that predominantly affects women in their reproductive years. Previous studies have yielded conflicting conclusions.</p><p><strong>Objective: </strong>This is an updated meta-analysis aiming to explore the connection between flavonoid supplementation and PCOS.</p><p><strong>Data sources: </strong>Seven databases were searched: Cochrane Library, PubMed, Web of Science, Embase, Wanfang, China Science and Technology Journal, and China National Knowledge Infrastructure, spanning from their inception to April 15, 2024.</p><p><strong>Data extraction: </strong>Two authors independently searched the databases using the search terms.</p><p><strong>Data analysis: </strong>Following strict inclusion criteria, 8 papers were ultimately included. This updated meta-analysis suggests that flavonoid supplementation could enhance follicular development, promote the proliferation and differentiation of follicular granulosa cells, elevate estradiol levels, and mitigate testosterone, C-reactive protein, and ovarian index levels.</p><p><strong>Conclusion: </strong>This analysis suggests that dietary flavonoids could potentially alleviate symptoms associated with PCOS.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42022382912.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":null,"pages":null},"PeriodicalIF":5.9000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/nutrit/nuae101","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
Context: Polycystic ovary syndrome (PCOS) is a prevalent hormonal imbalance that predominantly affects women in their reproductive years. Previous studies have yielded conflicting conclusions.
Objective: This is an updated meta-analysis aiming to explore the connection between flavonoid supplementation and PCOS.
Data sources: Seven databases were searched: Cochrane Library, PubMed, Web of Science, Embase, Wanfang, China Science and Technology Journal, and China National Knowledge Infrastructure, spanning from their inception to April 15, 2024.
Data extraction: Two authors independently searched the databases using the search terms.
Data analysis: Following strict inclusion criteria, 8 papers were ultimately included. This updated meta-analysis suggests that flavonoid supplementation could enhance follicular development, promote the proliferation and differentiation of follicular granulosa cells, elevate estradiol levels, and mitigate testosterone, C-reactive protein, and ovarian index levels.
Conclusion: This analysis suggests that dietary flavonoids could potentially alleviate symptoms associated with PCOS.
期刊介绍：
Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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