Cost-effectiveness of dapagliflozin plus standard treatment compared to standard therapy for the management of chronic kidney disease in Colombia.

IF 1.5 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2024-12-01 Epub Date: 2024-07-24 DOI:10.1080/14737167.2024.2382976

Pieralessandro Lasalvia, Eliana C Vásquez M, Jose Javier Arango Álvarez, Paola Garcia-Padilla

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Abstract

Background: The DAPA-CKD study showed that dapagliflozin added to standard treatment reduced the risk of chronic kidney disease progression, and death from renal or cardiovascular causes compared to placebo.

Objective: Assess the cost-effectiveness of dapagliflozin and standard treatment versus standard treatment alone for chronic kidney disease within the Colombian health system.

Methods: We employed a Markov model based on the DAPA-CKD study, tailored to the Colombian scenario. The model forecasted hospitalizations for heart failure, overall and cardiovascular mortality, and chronic kidney disease progression over a 10-year horizon with a 5% discount rate.

Results: Dapagliflozin combined with standard treatment is a cost-effective intervention in treating stage 2-4 CKD. In the base case, the ICER was US $5,366, below 1 GDP (US $6.558) per capita. This was consistent in the sensitivity analyses.

Conclusion: Our study showed that dapagliflozin, when combined with standard treatment, is cost-effective against standard treatment alone, aligning with Colombia's willingness-to-pay threshold.

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在哥伦比亚，达帕格列净加用标准疗法与标准疗法治疗慢性肾病的成本效益比较。

研究背景DAPA-CKD研究显示，与安慰剂相比，在标准治疗中加入达帕格列净可降低慢性肾脏病进展的风险，以及因肾脏或心血管原因死亡的风险：在哥伦比亚医疗系统内评估达帕格列净和标准治疗与单独标准治疗治疗慢性肾脏病的成本效益：我们采用了基于 DAPA-CKD 研究的马尔可夫模型，并根据哥伦比亚的具体情况进行了调整。该模型预测了心力衰竭住院率、总死亡率和心血管死亡率以及慢性肾脏病在10年内的进展情况，贴现率为5%：结果：Dapagliflozin 联合标准治疗是治疗 2-4 期 CKD 的一种经济有效的干预措施。在基础病例中，ICER 为 5,366 美元，低于人均 GDP（6.558 美元）。这与敏感性分析结果一致：我们的研究表明，达帕格列净与标准治疗联合使用，与单独使用标准治疗相比具有成本效益，符合哥伦比亚的支付意愿阈值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Pharmacoeconomics & Outcomes Research HEALTH CARE SCIENCES & SERVICES-PHARMACOLOGY & PHARMACY

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Pharmacoeconomics & Outcomes Research (ISSN 1473-7167) provides expert reviews on cost-benefit and pharmacoeconomic issues relating to the clinical use of drugs and therapeutic approaches. Coverage includes pharmacoeconomics and quality-of-life research, therapeutic outcomes, evidence-based medicine and cost-benefit research. All articles are subject to rigorous peer-review. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.