Nomogram models predicting prognosis for patients with t(8;21) acute myeloid leukemia: a SEER-based study.

IF 2 4区 医学 Q3 HEMATOLOGY Hematology Pub Date : 2024-12-01 Epub Date: 2024-07-24 DOI:10.1080/16078454.2024.2381169
Jiapeng Yang, Xiaohua Zhu, Honghong Zhang, Yang Fu, Zifeng Li, Ziping Xing, Yi Yu, Ping Cao, Jun Le, Junye Jiang, Jun Li, Hongsheng Wang, Maoxiang Qian, Xiaowen Zhai
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Abstract

Background: Acute myeloid leukemia (AML) with t(8;21) manifests as a diverse hematological malignancy. Although it was categorized into a favorable subtype, 30-40% of patients experience relapse. The objective of this research was to devise a nomogram for the accurate anticipation of both overall survival (OS) and cancer-specific survival (CSS) in t(8;21) AML.

Methods: From the Surveillance, Epidemiology, and End Results (SEER) database, individuals diagnosed with t(8;21) AML from 2000 to 2018 were selected. Prognostic factors for t(8;21) AML were identified using Cox regression analysis and Akaike Information Criterion (AIC), forming the basis for constructing prognostic nomograms.

Results: Key variables, including first primary tumor, age group, race, and chemotherapy, were identified and integrated into the nomogram. The C-index values for the nomograms predicting OS and CSS were 0.753 (validation: 0.765) and 0.764 (validation: 0.757), respectively. Ultimately, based on nomogram scores, patients were stratified into high-risk and low-risk groups, revealing significant disparities in both OS and CSS between these groups (P < 0.001).

Conclusion: This study innovatively crafted nomograms, incorporating clinical and therapeutic variables, to forecast the 1-, 3-, and 5-year survival rates for individuals with t(8;21) AML.

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预测 t(8;21) 急性髓性白血病患者预后的提名图模型:基于 SEER 的研究。
背景:带有t(8;21)的急性髓性白血病(AML)是一种多样化的血液恶性肿瘤。虽然它被归类为有利亚型,但仍有 30%-40% 的患者会复发。本研究的目的是设计一个提名图,用于准确预测t(8;21) AML患者的总生存期(OS)和癌症特异性生存期(CSS):从监测、流行病学和最终结果(SEER)数据库中选取了2000年至2018年期间诊断为t(8;21)急性髓细胞性白血病的患者。利用Cox回归分析和阿凯克信息标准(AIC)确定了t(8;21) AML的预后因素,为构建预后提名图奠定了基础:结果:确定了包括第一原发肿瘤、年龄组、种族和化疗在内的关键变量,并将其整合到预后图中。预测OS和CSS的提名图C指数值分别为0.753(验证:0.765)和0.764(验证:0.757)。最终,根据提名图评分将患者分为高风险组和低风险组,结果显示,这两组患者的OS和CSS均存在显著差异(P 结论:该研究创新性地制作了提名图,并将其用于预测癌症的OS和CSS:本研究结合临床和治疗变量,创新性地制作了提名图,用于预测 t(8;21)急性髓细胞性白血病患者的 1 年、3 年和 5 年生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hematology
Hematology 医学-血液学
CiteScore
2.60
自引率
5.30%
发文量
140
审稿时长
3 months
期刊介绍: Hematology is an international journal publishing original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. Of the fixed sections, annotations are accepted on any general or scientific field: technical annotations covering current laboratory practice in general hematology, blood transfusion and clinical trials, and current clinical practice reviews the consensus driven areas of care and management.
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