{"title":"A Simple Conversion of Aldoximes to Nitriles Using Thiourea Dioxide","authors":"Peidong Song, Zhe Cui, Tingting Meng, Haojie Rong, Mingzhen Mao, Cuifeng Yang","doi":"10.1002/ajoc.202400291","DOIUrl":null,"url":null,"abstract":"<p>Thiourea dioxide (TDO) has been demonstrated to be an efficient reagent for the transformation of aromatic, heteroaromatic, alkenyl and aliphatic aldoximes to respective nitriles in excellent yields. Furthermore, this method has been applied to the synthesis of fungicide cyazofamid from a commercial precursor using TDO as a pivotal dehydrating and reducing reagent. This new procedure offers simple and easily reproducible technique for nitrile synthesis and highlights the synthetic utility of TDO as a versatile reagent in organic chemistry.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"13 11","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ajoc.202400291","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Thiourea dioxide (TDO) has been demonstrated to be an efficient reagent for the transformation of aromatic, heteroaromatic, alkenyl and aliphatic aldoximes to respective nitriles in excellent yields. Furthermore, this method has been applied to the synthesis of fungicide cyazofamid from a commercial precursor using TDO as a pivotal dehydrating and reducing reagent. This new procedure offers simple and easily reproducible technique for nitrile synthesis and highlights the synthetic utility of TDO as a versatile reagent in organic chemistry.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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