Rotational Spectroscopy as a Tool to Characterize Sweet Taste: The Study of Dulcin

IF 2.5 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY ChemistryOpen Pub Date : 2024-07-25 DOI:10.1002/open.202400159
Dr. Gabriela Juarez, Elena R. Alonso, Raúl Aguado, Iker León
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Abstract

According to old theories of sweetness, the perception of sweet substances is closely linked to the arrangement of atoms within them. To assess the validity of these theories, we conducted an analysis of the structure of the artificial sweetener dulcin for the first time, utilizing microwave spectroscopy and a laser ablation source. These techniques have enabled the identification of two conformers, which are stabilized by an intramolecular hydrogen bond between the amino group and the phenyl ring. The observed conformations were examined in light of the Shallenberger-Acree-Kier molecular theory of sweet taste, and they align with the hypothesized criteria. Furthermore, the study illustrates how conformational relaxation can alter the equilibrium conformational distribution, resulting in the absence of certain conformers in the conformational landscape.

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旋转光谱法作为一种表征甜味的工具:杜松子研究
根据古老的甜味理论,甜味物质的感知与其中的原子排列密切相关。为了评估这些理论的正确性,我们首次利用微波光谱和激光烧蚀源对人工甜味剂杜冷丁的结构进行了分析。通过这些技术,我们确定了两种构象,它们通过氨基和苯环之间的分子内氢键而得到稳定。根据 Shallenberger-Acree-Kier 甜味分子理论对观察到的构象进行了研究,结果与假设的标准一致。此外,该研究还说明了构象弛豫如何改变平衡构象分布,导致构象景观中缺少某些构象。
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来源期刊
ChemistryOpen
ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.80
自引率
4.30%
发文量
143
审稿时长
1 months
期刊介绍: ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
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