Dr. Antonio Del Vecchio, Elisabetta Rosadoni, Lorenzo Ballerini, Dr. Angela Cuzzola, Prof. Filippo Lipparini, Dr. Paolo Ronchi, Dr. Sara Guariento, Dr. Matteo Biagetti, Prof. Marco Lessi, Prof. Fabio Bellina
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引用次数: 0
Abstract
A selective direct arylation of the different Csp2-H bonds of imidazo[2,1-b]thiazole with (hetero) aryl halides can be achieved simply by switching from a palladium catalyst system to the use of stoichiometric amounts of copper. The observed selectivity, also rationalized by DFT calculations, can be explained by a change in the mechanistic pathways between electrophilic palladation and base-promoted C−H metalation.
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