Effect of bariatric surgery on nutritional and metabolic parameters: does the type of antidepressant medication matter?

IF 2.9 3区医学 Q2 PSYCHIATRY Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Pub Date : 2024-07-25 DOI:10.1007/s40519-024-01680-6

Katherine J P Schwenger, Yasaman Ghorbani, Fadi Alkass, Tulasi Patel, Timothy D Jackson, Allan Okrainec, Johane P Allard

{"title":"Effect of bariatric surgery on nutritional and metabolic parameters: does the type of antidepressant medication matter?","authors":"Katherine J P Schwenger, Yasaman Ghorbani, Fadi Alkass, Tulasi Patel, Timothy D Jackson, Allan Okrainec, Johane P Allard","doi":"10.1007/s40519-024-01680-6","DOIUrl":null,"url":null,"abstract":"Purpose: Depression is prevalent in patients undergoing bariatric surgery (BSx). Long-term use of antidepressant is associated with weight gain, particularly the use of selective serotonin reuptake inhibitors (SSRIs). Little is known about whether different types of antidepressants affect the response to BSx. The purpose of this study was to determine the relationship between SSRI use and nutritional and biochemical measurements in those with obesity pre-/post-BSx.Methods: This is a cross-sectional and prospective cohort study. Patients were enrolled pre-BSx and divided into 3 groups: SSRI, non-SSRI and no antidepressant. Nutritional, biochemical and pharmacological data were collected pre- and 6 months post-BSx.Results: Pre-BSx, 77 patients were enrolled: 89.6% female, median age 45 years and body mass index (BMI) of 45.3 kg/m2. 14.3% were taking SSRIs and had a significantly higher BMI (52.1 kg/m2) compared to 62.3% in no antidepressant (46.0 kg/m2) and 23.4% in non-SSRI antidepressants (43.1 kg/m2). At 6 months post-BSx (n = 58), the SSRI group still had significantly higher BMI in comparison to the other two groups. No other significant differences found between groups.Conclusion: Despite higher BMI, patients taking SSRI and undergoing BSx had similar responses, based on nutritional and biochemical parameters, to those on non-SSRI or no antidepressants.Level of evidence: Level III: Evidence obtained from well-designed cohort or case-control analytic studies.","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272803/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40519-024-01680-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Depression is prevalent in patients undergoing bariatric surgery (BSx). Long-term use of antidepressant is associated with weight gain, particularly the use of selective serotonin reuptake inhibitors (SSRIs). Little is known about whether different types of antidepressants affect the response to BSx. The purpose of this study was to determine the relationship between SSRI use and nutritional and biochemical measurements in those with obesity pre-/post-BSx.

Methods: This is a cross-sectional and prospective cohort study. Patients were enrolled pre-BSx and divided into 3 groups: SSRI, non-SSRI and no antidepressant. Nutritional, biochemical and pharmacological data were collected pre- and 6 months post-BSx.

Results: Pre-BSx, 77 patients were enrolled: 89.6% female, median age 45 years and body mass index (BMI) of 45.3 kg/m². 14.3% were taking SSRIs and had a significantly higher BMI (52.1 kg/m²) compared to 62.3% in no antidepressant (46.0 kg/m²) and 23.4% in non-SSRI antidepressants (43.1 kg/m²). At 6 months post-BSx (n = 58), the SSRI group still had significantly higher BMI in comparison to the other two groups. No other significant differences found between groups.

Conclusion: Despite higher BMI, patients taking SSRI and undergoing BSx had similar responses, based on nutritional and biochemical parameters, to those on non-SSRI or no antidepressants.

Level of evidence: Level III: Evidence obtained from well-designed cohort or case-control analytic studies.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

减肥手术对营养和代谢参数的影响：抗抑郁药物的类型是否重要？

目的：抑郁症在接受减肥手术（BSx）的患者中很普遍。长期服用抗抑郁药与体重增加有关，尤其是选择性血清素再摄取抑制剂（SSRIs）。对于不同类型的抗抑郁药是否会影响 BSx 的反应，人们知之甚少。本研究旨在确定 BSx 前后肥胖患者使用 SSRI 与营养和生化指标之间的关系：这是一项横断面前瞻性队列研究。方法：这是一项横断面前瞻性队列研究：SSRI组、非SSRI组和未服用抗抑郁药组。研究收集了BSx前和BSx后6个月的营养、生化和药理学数据：BSx前，77名患者入组：89.6%为女性，中位年龄为45岁，体重指数（BMI）为45.3 kg/m2。14.3%的患者服用 SSRIs，其体重指数（52.1 kg/m2）明显高于未服用抗抑郁药物的 62.3%（46.0 kg/m2）和未服用 SSRI 抗抑郁药物的 23.4%（43.1 kg/m2）。在 BSx 治疗后 6 个月（n = 58），SSRI 组的 BMI 仍明显高于其他两组。各组之间未发现其他明显差异：结论：尽管BMI较高，但根据营养和生化指标，服用SSRI并接受BSx治疗的患者与未服用SSRI或未使用抗抑郁药物的患者反应相似：III级：从设计良好的队列或病例对照分析研究中获得的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 医学-精神病学

CiteScore

6.50

自引率

10.30%

发文量

170

审稿时长

>12 weeks

期刊介绍： Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity is a scientific journal whose main purpose is to create an international forum devoted to the several sectors of eating disorders and obesity and the significant relations between them. The journal publishes basic research, clinical and theoretical articles on eating disorders and weight-related problems: anorexia nervosa, bulimia nervosa, subthreshold eating disorders, obesity, atypical patterns of eating behaviour and body weight regulation in clinical and non-clinical populations.