Effects and action mechanism of gonadotropins on ovarian follicular cells: A novel role of Sphingosine-1-Phosphate (S1P). A review

IF 2.1 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM General and comparative endocrinology Pub Date : 2024-07-22 DOI:10.1016/j.ygcen.2024.114593
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Abstract

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) control antral follicular growth by regulating several processes, such as the synthesis of hormones and signaling molecules, proliferation, survival, apoptosis, luteinization, and ovulation. To exert these effects, gonadotropins bind to their respective Gs protein-coupled receptors, activating the protein kinase A (PKA) pathway or recruiting Gq proteins to activate protein kinase C (PKC) signaling. Although the action mechanism of FSH and LH is clear, recently, it has been shown that both gonadotropins promote the synthesis of sphingosine-1-phosphate (S1P) in granulosa and theca cells through the activation of sphingosine kinase 1. Moreover, the inhibition of SPHKs reduces S1P synthesis, cell viability, and the proliferation of follicular cells in response to gonadotropins, and the addition of S1P to the culture medium increases the proliferation of granulosa and theca cells without apparent effects on sexual steroid synthesis. Therefore, we consider that S1P is a crucial signaling molecule that complements the canonical gonadotropin pathway to promote the proliferation and viability of granulosa and theca cells.

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促性腺激素对卵泡细胞的影响和作用机制:1-磷酸腺苷(S1P)的新作用。综述。
卵泡刺激素(FSH)和黄体生成素(LH)通过调节激素和信号分子的合成、增殖、存活、凋亡、黄体化和排卵等多个过程来控制前卵泡的生长。为了发挥这些作用,促性腺激素与各自的Gs蛋白偶联受体结合,激活蛋白激酶A(PKA)途径或招募Gq蛋白激活蛋白激酶C(PKC)信号传导。尽管 FSH 和 LH 的作用机制已经明确,但最近的研究表明,这两种促性腺激素都能通过激活鞘磷脂激酶 1 促进颗粒细胞和癌细胞中鞘磷脂-1-磷酸(S1P)的合成。此外,抑制 SPHKs 会降低 S1P 的合成、细胞活力和卵泡细胞对促性腺激素的增殖反应,而在培养基中添加 S1P 会增加颗粒细胞和癌细胞的增殖,但对性类固醇的合成无明显影响。因此,我们认为S1P是一种重要的信号分子,它补充了典型的促性腺激素途径,促进颗粒细胞和theca细胞的增殖和活力。
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来源期刊
General and comparative endocrinology
General and comparative endocrinology 医学-内分泌学与代谢
CiteScore
5.60
自引率
7.40%
发文量
120
审稿时长
2 months
期刊介绍: General and Comparative Endocrinology publishes articles concerned with the many complexities of vertebrate and invertebrate endocrine systems at the sub-molecular, molecular, cellular and organismal levels of analysis.
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