Methods to Track Effective Doses from Airborne Radioactive Emissions for Compliance with 40 CFR 61, SUBPART H.

IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Health physics Pub Date : 2024-12-01 Epub Date: 2024-07-24 DOI:10.1097/HP.0000000000001872
Amber M Harshman, William L McCarter
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Abstract

Abstract: US Department of Energy national laboratories can play an integral role in not only the advancement of science but also in the treatment of various medical conditions through research and development activities conducted at radioisotope production facilities. A project has been underway at Oak Ridge National Laboratory since 2016 whose mission is to produce and supply the radioisotope 227 Ac, which is used in a radiopharmaceutical developed to treat certain types of prostate cancer and bone metastases. Production activities result in the environmental release of airborne radioactive emissions, which are governed by Clean Air Act regulations described in 40 CFR Part 61, Subpart H. Stack 3039, the source that emits radioactive effluents from 227 Ac production, is subject to additional requirements outlined in American National Standards Institute (ANSI) N13.1-1969 due to its grandfathered status. Radioactive emissions are limited to levels below those that would cause annual compliance dose standards for members of the public to be exceeded and stack 3039 to lose its grandfathered status. To allow for maximum production of 227 Ac without exceeding relevant dose limits, monthly tracking of project emissions and resulting CAP88-PC modeled effective doses to a maximally exposed individual have been implemented. Four years of tracking data were compiled and analyzed to identify additional methods that could be used to estimate project doses more frequently, potentially further optimizing 227 Ac production while maintaining compliance with applicable regulations.

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跟踪空气中放射性排放有效剂量的方法,以符合 40 CFR 61,H 分节的规定。
摘要:美国能源部国家实验室通过在放射性同位素生产设施开展研发活动,不仅能在科学进步方面发挥不可或缺的作用,还能在治疗各种病症方面发挥不可或缺的作用。自 2016 年以来,橡树岭国家实验室一直在开展一个项目,其任务是生产和供应放射性同位素 227Ac,该同位素用于开发一种放射性药物,以治疗某些类型的前列腺癌和骨转移。生产活动会导致空气中的放射性排放物释放到环境中,这些排放物受《清洁空气法》(Clean Air Act)第 40 CFR 61 部分 H 子部分的规定管辖。堆栈 3039 是 227Ac 生产过程中排放放射性废水的源头,由于其原始状态,因此必须遵守美国国家标准学会 (ANSI) N13.1-1969 中列出的额外要求。放射性排放被限制在低于会导致公众年度合规剂量标准超标和 3039 烟囱失去祖父地位的水平。为了在不超过相关剂量限制的情况下最大限度地生产 227Ac,对项目排放量和由此产生的 CAP88-PC 建模有效剂量进行了每月跟踪。对四年的跟踪数据进行了汇编和分析,以确定可用于更频繁地估算项目剂量的其他方法,从而有可能进一步优化 227Ac 的生产,同时保持符合适用法规。
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来源期刊
Health physics
Health physics 医学-公共卫生、环境卫生与职业卫生
CiteScore
4.20
自引率
0.00%
发文量
324
审稿时长
3-8 weeks
期刊介绍: Health Physics, first published in 1958, provides the latest research to a wide variety of radiation safety professionals including health physicists, nuclear chemists, medical physicists, and radiation safety officers with interests in nuclear and radiation science. The Journal allows professionals in these and other disciplines in science and engineering to stay on the cutting edge of scientific and technological advances in the field of radiation safety. The Journal publishes original papers, technical notes, articles on advances in practical applications, editorials, and correspondence. Journal articles report on the latest findings in theoretical, practical, and applied disciplines of epidemiology and radiation effects, radiation biology and radiation science, radiation ecology, and related fields.
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