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Confessions of an LNT Heretic: What Happens When You Challenge Biomedical and Environmental Dogma: Rebuttal of Beyea Commentary 2024. 一个LNT异端的自白:当你挑战生物医学和环境教条时会发生什么:对Beyea评论的反驳2024。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1097/HP.0000000000002052
Edward J Calabrese
<p><p>This article provides both a personal reflection concerning major professional and scientific challenges that can occur when evaluating the concept of hormesis and the historical foundations of cancer risk assessment/linear non-threshold (LNT) dose-response model and a detailed response to a recent critic. The assessment briefly captures what happened when an established mid-career scientist (i.e., the author) somehow went "astray" and challenged the central dose-response dogma of the scientific community "establishment" and regulatory agencies. It highlights what can and did happen to me when I was perceived to be a threat to vested interests; and how professional forces became animated, mobilized, and organized to marginalize me and my ideas/research to destroy my reputation and even get me removed from my position of having a tenured university full professorship. This historical background and personal story provide insights on their own but also necessary context when addressing new or recycled criticisms generated out of a mixture of legitimate scientific questions and/or ideological bias. There are also deep and vexing frustrations due to my substantial successes in the hormesis and cancer risk assessment areas. This framework provides a necessary backdrop to address recent criticisms of the Health Physics Society (HPS) documentary, The History of the Linear No-Threshold Model , and my publications on this topic that were the principal foundations for this documentary. In brief, Beyea's evaluation in the Health Physics Journal ( HPJ ) gives the impression that it is a broad evaluation of my research on the historical foundations of cancer risk assessment. Yet, Beyea addressed only a very limited set of discoveries that were discussed in the documentary. However, there have been numerous significant discoveries (about two dozen) published since the release of the documentary that he failed to acknowledge. All the new discoveries support, greatly enrich/extend, and do not contradict any aspect of the documentary. In addition, the Beyea assessment represents a recycling of information from his previous two highly compromised papers of nearly a decade ago. These papers, including the present one, display his confirmation bias that is strongly associated with his failure to use primary source materials, a source of novelty and significance in my historical research on cancer risk assessment. Failure to use primary sources greatly diminishes the historical and scientific value of the Beyea article, making it susceptible to secondary source opinion misinterpretations, frank errors, and bias, as repeatedly shown herein. In addition, Beyea attempts to damage my personal and professional standing/reputation, possibly violating ethical guidelines of the HPJ . Thus, the scientific basis for his comments is generally trivial and often devoid of historical foundation and accuracy, while failing to be representative of my body of work over the past
本文提供了个人对评估激效概念和癌症风险评估/线性非阈值(LNT)剂量-反应模型的历史基础时可能出现的主要专业和科学挑战的反思,以及对最近批评者的详细回应。该评估简要地描述了当一位职业生涯中期的知名科学家(即作者)不知何故“误入歧途”并挑战科学界“建制派”和监管机构的核心剂量-反应教条时所发生的事情。它强调了当我被视为对既得利益的威胁时,我可能会发生什么,也确实发生了什么;以及专业力量如何变得活跃、动员和组织起来,使我和我的想法/研究边缘化,从而破坏我的声誉,甚至使我失去终身大学正教授的地位。这个历史背景和个人故事提供了他们自己的见解,但也为解决由合法的科学问题和/或意识形态偏见混合产生的新的或循环的批评提供了必要的背景。由于我在激效和癌症风险评估领域的巨大成功,也有深刻而令人烦恼的挫折。这个框架提供了一个必要的背景,以解决最近对健康物理学会(HPS)纪录片《线性无阈值模型的历史》的批评,以及我关于这一主题的出版物,这些出版物是这部纪录片的主要基础。简而言之,Beyea在健康物理杂志(HPJ)上的评价给人的印象是,这是对我关于癌症风险评估历史基础的研究的广泛评价。然而,贝耶只谈到了纪录片中讨论的非常有限的一组发现。然而,自纪录片发布以来,有许多重要的发现(大约24个)被发表,但他没有承认。所有的新发现都支持、极大地丰富/扩展了纪录片的任何方面,而不与之矛盾。此外,贝耶的评估报告是对他近10年前发表的两篇受到严重损害的论文中的信息的重复利用。这些论文,包括这篇论文,显示了他的确认偏误,这与他没有使用第一手资料密切相关,这是我在癌症风险评估的历史研究中新颖和重要的来源。未能使用第一手资料大大降低了Beyea文章的历史和科学价值,使其容易受到第二手资料观点的误解,坦率的错误和偏见,正如本文反复显示的那样。此外,Beyea试图损害我的个人和职业地位/声誉,可能违反了HPJ的道德准则。因此,他的评论的科学依据通常是微不足道的,往往缺乏历史基础和准确性,同时也不能代表我过去二十年的工作。Beyea未能使用基于原始资料的研究方法,特别是当这些文献丰富、普遍可用,并且对癌症风险评估的历史研究至关重要时,这代表了一个本应在同行评审过程中得到解决和纠正的根本缺陷。如果做不到这一点,就会发表一篇历史上有缺陷和不可靠的论文,并使他们的审查过程的公正性受到质疑。
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引用次数: 0
False and Misleading Statements Leading to an Unreliable Source of Information Regarding Early Research into Radiation Dose-Response: Part 1. A Response to Beyea. 关于早期辐射剂量反应研究的虚假和误导性陈述导致信息来源不可靠:第1部分。对贝耶的回应。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1097/HP.0000000000002082
John Cardarelli

A commentary written by Jan Beyea claimed that the HPS interview of Edward Calabrese on the historical evolution of the linear no-threshold model was unreliable because it overlooked key historical text and statistical concepts. Beyea states that the purpose of his commentary was to defend the integrity of historical figures and committees from the accusation of scientific misconduct as presented by Calabrese. Based on his review of the video series and other documents, he provided what he defined as evidence of errors of fact, reasoning, and statistics to support his position. If true, Beyea's work would have the effect of impugning the reputation of Calabrese, myself, and the credibility of the HPS. This response intends to expose the issues with Beyea's commentary, including mischaracterization of Calabrese's work, lack of objectivity, misleading and factually incorrect statements, reliance on secondary sources, ignoring evidence specifically provided in the video series, and failing to address evidence provided in primary-sourced documents that contradict his conclusions. As a result, the reliability of Beyea's commentary is highly compromised, representing a serious lack of scholarship, research, and objectivity such that it should be retracted by Health Physics Journal based on the Committee on Publication Ethics guidelines. The HPS interview-style documentary reflects historical events based on primary-sourced documents as discovered by Calabrese. Scientific debate on this topic is necessary to progress our field, but the debate must be supported by facts with primary-sourced evidence and not driven by outdated public policies, logical fallacies, or ideology.

Jan Beyea撰写的一篇评论声称,HPS对Edward Calabrese关于线性无阈值模型的历史演变的采访是不可靠的,因为它忽略了关键的历史文本和统计概念。贝耶表示,他评论的目的是为了捍卫历史人物和委员会的诚信,免受卡拉布雷斯提出的科学不端行为的指控。根据他对视频系列和其他文件的回顾,他提供了他所定义的事实、推理和统计错误的证据来支持他的立场。如果这是真的,贝耶尔的研究将会对卡拉布雷斯、我本人以及HPS的声誉造成质疑。本回应旨在揭露Beyea评论中的问题,包括对Calabrese工作的错误描述,缺乏客观性,误导性和事实错误的陈述,依赖二手来源,忽视视频系列中具体提供的证据,以及未能解决与他的结论相矛盾的第一手资料提供的证据。因此,Beyea评论的可靠性受到严重损害,代表着严重缺乏学术,研究和客观性,因此应该由《健康物理杂志》根据出版伦理委员会的指导方针撤回。HPS采访风格的纪录片反映了基于卡拉布雷斯发现的第一手资料的历史事件。关于这一主题的科学辩论对于我们的领域的进步是必要的,但辩论必须以有第一手证据的事实为支撑,而不是被过时的公共政策、逻辑谬误或意识形态所驱动。
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引用次数: 0
Investigating Tertiary X-radiation Exposure in C-arm Units: Risks and Mitigation. 调查c臂单位的三次x射线暴露:风险和缓解。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2025-08-29 DOI: 10.1097/HP.0000000000002032
Nada Alomairy

Fluoroscopic C-arm units are used routinely in surgical procedures, but they pose potential radiation hazards, particularly in terms of scatter and tertiary exposure to healthcare providers, which can lead to long-term health effects. This study investigates the level of scatter radiation emitted by the C-arm during Dynamic Hip Screw (DHS) surgery across four general hospitals. A water phantom was placed in the center of the operating table, simulating an average patient. OSL dosimeters were placed at standardized distances and heights around all sides of the phantom to measure scatter radiation exposure. The OSL dosimeter readings recorded consistent scatter radiation levels for all positions (A, B, C, D, and E) and heights (0.5 m, 1.0 m, and 2.0 m). Exposure levels ranged from 0.06 to 0.09 mSv, with negligible variations based on distance from the phantom. One-way ANOVA results showed differences in scatter radiation exposure between hospitals (F-statistic = 2.68, p = 0.044). Despite inter-hospital variations, exposure levels were below international safety levels. Results indicate that healthcare workers are unlikely to surpass the yearly dose levels of radiation during normal use. Routine exposure highlights the necessity for proper safety precautions, such as lead aprons, shielding barriers, and room layout optimization. Future studies should take C-arm shielding and positioning into account to continue reducing exposure to scatter radiation. Further research is recommended to evaluate long-term cumulative exposure and improve radiation safety protocols.

摘要:透视c型臂装置在外科手术中是常规使用的,但它们具有潜在的辐射危害,特别是在散射和对医疗保健提供者的三次照射方面,这可能导致长期健康影响。本研究调查了四家综合医院在动态髋螺钉(DHS)手术中c臂放射的散射辐射水平。在手术台中央放置一个水幻影,模拟一个普通病人。OSL剂量计被放置在标准距离和高度周围的幻影,以测量散射辐射暴露。OSL剂量计读数记录了所有位置(A、B、C、D和E)和高度(0.5 m、1.0 m和2.0 m)一致的散射辐射水平。暴露水平范围为0.06至0.09毫西弗,根据与幻像的距离变化可以忽略不计。单因素方差分析结果显示医院间散射辐射暴露存在差异(f统计量= 2.68,p = 0.044)。尽管医院间存在差异,但暴露水平低于国际安全水平。结果表明,卫生保健工作者在正常使用期间不太可能超过辐射的年剂量水平。常规暴露强调了适当的安全预防措施的必要性,例如铅围裙,屏蔽屏障和房间布局优化。未来的研究应考虑c臂的屏蔽和定位,以继续减少散射辐射的暴露。建议进一步研究以评估长期累积照射并改进辐射安全规程。
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引用次数: 0
Design of Radiation Shielding for Terawatt-level High-power Laser Facility. 太瓦级大功率激光设备的辐射屏蔽设计。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2025-09-19 DOI: 10.1097/HP.0000000000002021
Shenghan Cheng, Zhilin Chen, Yu Li, Wenxiang Jiang, Minxiang Shu, Taiping Peng

A wide range of particle species, including neutrons, electrons, and photons, will be generated in a terawatt-level (TW) high-power laser facility, which poses considerable challenges for the development of effective radiation shielding solutions. The safety of both facility personnel and the public requires specified design considerations for these shielding systems. The Monte-Carlo code JMCT was employed to simulate and design the shielding structure for the TW facility. We calculated the radiation dose distribution throughout the entire facility for both single-shot and multi-shot operational modes. Our findings indicate that the strategic use of locally thickened shielding walls and mobile shielding measures can effectively mitigate radiation risks in TW-level laser facilities, ensuring that radiation doses within the personnel working area remain within regulatory limits. The results demonstrate that with these shielding strategies in place, the occupational exposure dose in the control room and the clean room can be confined to below 3 mSv y -1 , while the public dose remains below 0.1 mSv y -1 , considering an experimental frequency of 5 × 10 6 shots per year for overdense plasma experiments and 1 × 10 4 shots per year for underdense plasma experiments. The radiation shielding design method and results presented in this paper can serve as a reference for similar devices.

摘要:太瓦级(TW)高功率激光设备将产生包括中子、电子和光子在内的多种粒子,这对开发有效的辐射屏蔽解决方案提出了相当大的挑战。设施人员和公众的安全需要对这些屏蔽系统进行特定的设计考虑。采用蒙特卡罗程序JMCT对TW设施的屏蔽结构进行了模拟和设计。我们计算了单次和多次操作模式下整个设施的辐射剂量分布。研究结果表明,局部加厚屏蔽墙和移动屏蔽措施可以有效降低tw级激光设施的辐射风险,确保人员工作区域内的辐射剂量保持在法规限制范围内。结果表明,考虑到超密等离子体实验频率为5 × 106次/年,低密等离子体实验频率为1 × 104次/年,在这些屏蔽策略的实施下,控制室和洁净室的职业暴露剂量可以控制在3毫西弗-1以下,而公众暴露剂量则保持在0.1毫西弗-1以下。本文提出的辐射屏蔽设计方法和结果可为类似设备提供参考。
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引用次数: 0
Do We Need the LNT Hypothesis in Radiation Protection? Could a Traffic Light Model Be a Practicable Solution? 辐射防护是否需要LNT假说?交通灯模式是否可行?
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2025-10-24 DOI: 10.1097/HP.0000000000002029
Hansruedi Völkle

The linear no-threshold hypothesis (commonly known as LNT) has received increasing criticism in recent years. LNT assumes that the damaging effects of ionizing radiation, that is, stochastic effects such as cancer and genetic or teratogenic effects, increase linearly with dose and without a lower dose threshold. However, statistically verified data on the relationship between radiation and effects are only obtained for the range above 100 mSv y -1 , which is why linear extrapolation downward is carried out for the range of low radiation doses, i.e., below 100 mSv y -1 . Today's radiation protection systems are based on this principle. To place radiation protection on a different basis (that is, no longer on the LNT hypothesis), a traffic light model is proposed. It uses natural radiation exposure as a reference but maintains the existing limits and everything in radiation protection that has proven effective. What does change, however, is the lower end of the optimization range, according to the ALARA recommendation. For the justification of today's levels of exceptions, the precautionary principle is applied.

线性无阈假设(通常称为LNT)近年来受到越来越多的批评。LNT假定电离辐射的破坏性效应,即随机效应,如癌症和遗传或致畸效应,随剂量线性增加,没有较低的剂量阈值。但是,只有在100毫西弗-1以上的范围内才获得了经统计证实的辐射与效应之间关系的数据,这就是为什么对低辐射剂量范围,即低于100毫西弗-1的范围进行了向下的线性外推。今天的辐射防护系统就是基于这个原理。为了将辐射防护放在一个不同的基础上(即不再基于LNT假设),我们提出了一个交通灯模型。它以自然辐射照射量为参考,但维持现有的限制和所有已被证明有效的辐射防护措施。然而,根据ALARA的建议,真正改变的是优化范围的低端。为了证明今天的例外水平是合理的,我们采用了预防原则。
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引用次数: 0
Results of Provincial Health Institutions Participating in Individual Monitoring Intercomparisons-China, 2022 to 2024. 2022 - 2024年中国省级卫生机构参与个体监测的比较结果
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1097/HP.0000000000002024
Pin Gao, Kaiyi Wang, Yanqiu Ding, Wen Guo

To improve monitoring capabilities, China CDC organized individual monitoring intercomparisons, which provincial health institutions participated in from 2022 to 2024. The irradiation schemes and evaluation criteria were designed in accordance with GBZ 207-2016, "Testing criteria of personnel dosimetry performance for external exposure." The Type II (photon) test specified in the standard was selected as the intercomparison type, with Hp (10) as the target quantity. Each institution submitted 21 dosimeters for participation in the intercomparison exercises. Irradiation schemes with various radiation quality and incident angles were randomly assigned to each participant. Out of 580 P i values, 82.6% (479) were classified as excellent, and 96.9% (562) met the qualification criteria. Four institutions reported 18 unqualified P i values. These demonstrate the reliable performance of the dosimetry systems. These intercomparisons helped participants identify system deviations and enabled radiation health administrative departments to grasp the capabilities of each institution, thus strengthening the protection of the occupational health of radiological workers.

摘要:为提高监测能力,中国疾病预防控制中心于2022 - 2024年组织省级卫生机构参与单项监测比对。照射方案和评价标准按照GBZ 207-2016《人员外照射剂量学性能试验标准》设计。选择标准中规定的II型(光子)测试作为比对类型,以Hp(10)为目标量。每个机构提交了21个剂量计参加相互比较工作。不同辐射质量和入射角的辐照方案被随机分配给每个参与者。在580个Pi值中,82.6%(479个)被评为优秀,96.9%(562个)符合合格标准。4个机构报告了18个不合格的圆周率值。这些证明了剂量测定系统的可靠性能。这些相互比较有助于参与者识别系统偏差,使辐射卫生行政部门能够掌握各机构的能力,从而加强对放射工作人员职业健康的保护。
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引用次数: 0
Considering Radiation Safety Program Image. 考虑到辐射安全计划的形象。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1097/HP.0000000000002010
Robert J Emery, Janet M Gutierrez

Commercial businesses have long known that the image of an organization is critical to ultimate success. Significant resources are invested in marketing, logos, colors, signage, appearance, informational brochures, and the like because expenditures on these aspects have repeatedly proven to produce a measurable return on investment. The term "image" can be defined in many ways, but within the context of the effort described here, it is a tangible or visible representation of an entity. A radiation safety program's image can be based on many operational outcome elements, such as personnel doses, findings from regulatory compliance inspections, and measured client satisfaction. Described here are three other program image components that may be considered: the radiation safety program's website, program staff appearance, and program organizational charts. Data regarding the prevalence of current practices being carried out within operational college and university safety programs as they relate to image were measured via a series of simple online polls. Although the assessments described here were focused primarily on university environmental health and safety programs, each included specific consideration of any radiation safety component. The findings stemming from the analysis of these convenience sample polls examining the blind testing of program internet website search capabilities, the norms regarding program staff recognition on campus, and the common errors associated with organizational charts all can serve as a guide to improve radiation safety program image that, in turn, can maintain or enhance program reputation and support.

摘要:商业企业早就知道组织形象对最终成功至关重要。在市场营销、标识、颜色、标牌、外观、信息手册等方面投入了大量资源,因为在这些方面的支出已被反复证明可以产生可衡量的投资回报。术语“图像”可以以多种方式定义,但在这里描述的上下文中,它是实体的有形或可见的表示。辐射安全计划的形象可以基于许多操作结果元素,例如人员剂量、法规遵从性检查的结果和测量的客户满意度。这里描述了其他三个可以考虑的程序图像组件:辐射安全程序的网站,程序工作人员的外观和程序组织结构图。通过一系列简单的在线调查,我们了解了学院和大学安全项目中与形象相关的现行做法的流行程度。虽然这里描述的评估主要集中在大学环境健康和安全项目上,但每项评估都包括对任何辐射安全成分的具体考虑。调查结果源于对这些便利抽样调查的分析,这些调查检查了项目互联网网站搜索能力的盲测,关于校园项目工作人员认可的规范,以及与组织图表相关的常见错误,这些都可以作为改善辐射安全项目形象的指南,反过来,可以维护或提高项目的声誉和支持。
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引用次数: 0
HEALTH PHYSICS SOCIETY . 2026 AFFILIATE MEMBERS. 健康物理学会。2026个附属会员。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1097/01.HP.0001182188.65905.47
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引用次数: 0
Fetal Dose Reduction in CT Pulmonary Angiography Using Internal Barium Shielding: A Monte Carlo Simulation Study. 利用内钡屏蔽降低胎儿CT肺血管造影剂量:蒙特卡罗模拟研究。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1097/HP.0000000000002012
Maroine Tahiri, Yassine Benameur, Mina Azeddou, Redouane El Baydaoui, Mounir Mkimel

CT pulmonary angiography (CTPA) is a key diagnostic tool for embolic pulmonary disease during pregnancy, despite its associated high radiation exposure. To minimize the fetal radiation dose, a new technique using internal shielding has been introduced, which reduces internal scattering. This study focuses on evaluating how barium-based internal shielding impacts the reduction of fetal organ radiation dose during CTPA. For instance, a validated GATE/GEANT4 model was used to simulate CTPA acquisition. Fetal organ doses were obtained via a simulated third trimester pregnant model (Katja). In order to simulate internal shielding, Contrast agent (CA) of different sulfate barium concentrations was incorporated in the digestive cavity of the model. Also, fetal organ doses were calculated with and without internal shielding, and levels of fetal organ dose reductions were assessed for all CA concentrations. The mean fetal organ dose for CTPA without CA was 0.71 mGy. According to results, internal shielding induces a reduction in organ dose, since fetal organ dose reductions ranged between 55.89% and 69.41% with 80% CA. Furthermore, it was observed that the more CA concentration increases, the more dose reduction increases. In addition, fetal brain dose was reduced by 55.54%, 59.67%, 61.80%, and 62.94% for CA concentrations of 20%, 40%, 60%, and 80%, respectively. Clearly, this study will help provide a better assessment of fetal dose reduction via barium shielding in CTPA.

摘要:CT肺血管造影(CTPA)是妊娠期间栓塞性肺部疾病的关键诊断工具,尽管其相关的高辐射暴露。为了最大限度地减少胎儿的辐射剂量,引入了一种使用内部屏蔽的新技术,以减少内部散射。本研究的重点是评估钡基内屏蔽对CTPA期间胎儿器官辐射剂量降低的影响。例如,使用经过验证的GATE/GEANT4模型来模拟CTPA的获取。通过模拟妊娠晚期模型(Katja)获得胎儿器官剂量。为了模拟内部屏蔽,在模型消化腔内加入不同硫酸钡浓度的造影剂(CA)。此外,计算了有和没有内屏蔽的胎儿器官剂量,并评估了所有CA浓度下胎儿器官剂量减少的水平。没有CA的CTPA的平均胎儿器官剂量为0.71 mGy。结果表明,当CA浓度为80%时,内屏蔽诱导器官剂量降低,胎儿器官剂量降低幅度在55.89% ~ 69.41%之间,CA浓度越高,剂量降低幅度越大。CA浓度为20%、40%、60%和80%时,胎脑剂量分别降低55.54%、59.67%、61.80%和62.94%。显然,这项研究将有助于更好地评估CTPA中通过钡屏蔽降低胎儿剂量的效果。
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引用次数: 0
Letter From the Editor: Reply to Calabrese. 编辑的信:给卡拉布雷斯的回信。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1097/HP.0000000000002113
Brant A Ulsh
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引用次数: 0
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Health physics
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