{"title":"Correction to “The 18th International HLA & Immunogenetics workshop project report: Creating fully representative MHC reference haplotypes”","authors":"","doi":"10.1111/tan.15615","DOIUrl":null,"url":null,"abstract":"<p>\n <span>Pollock, NR</span>, <span>Farias, TDJ</span>, <span>Kichula, KM</span>, et al. <span>The 18th International HLA & Immunogenetics workshop project report: Creating fully representative MHC reference haplotypes</span>. <i>HLA.</i> <span>2024</span>; <span>103</span>(<span>6</span>):e15568. doi:10.1111/tan.15568\n </p><p>In the article, the Abstract section was inadvertently removed. The Abstract should read:</p><p><b>Abstract</b></p><p>A fundamental endeavor of the International Histocompatibility and Immunogenetics Workshop (IHIW) was assembling a collection of DNA samples homozygous through the <i>MHC</i> genomic region. This collection proved invaluable for assay development in the histocompatibility and immunogenetics field, for generating the human reference genome, and furthered our understanding of <i>MHC</i> diversity. Defined by their <i>HLA-A, -B, -C</i> and <i>-DRB1</i> alleles, the combined frequency of the haplotypes from these individuals is ~20% in Europe. Thus, a significant proportion of <i>MHC</i> haplotypes, both common and rare throughout the world, and including many associated with disease, are not yet represented. In this workshop component, we are collecting the next generation of <i>MHC</i>-homozygous samples, to expand, diversify and modernize this critical community resource that has been foundational to the field. We asked laboratories worldwide to identify samples homozygous through all <i>HLA class I</i> and/or <i>HLA class II</i> genes, or through whole-genome SNP genotyping or sequencing, to have extensive homozygosity tracts within the <i>MHC</i> region. The focus is non-Europeans or those having <i>HLA</i> haplotypes less common in Europeans. Through this effort, we have obtained samples from 537 individuals representing 294 distinct haplotypes, as determined by their <i>HLA class I</i> and <i>II</i> alleles, and an additional 50 haplotypes distinct in <i>HLA class I</i> or <i>II</i> alleles. Although we have expanded the diversity, many populations remain underrepresented, particularly from Africa, and we encourage further participation. The data will serve as a resource for investigators seeking to characterise variation across the <i>MHC</i> genomic region for disease and population studies.</p><p>The abstract has been added to the online version.</p><p>We apologize for this error.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.15615","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"HLA","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/tan.15615","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Pollock, NR, Farias, TDJ, Kichula, KM, et al. The 18th International HLA & Immunogenetics workshop project report: Creating fully representative MHC reference haplotypes. HLA.2024; 103(6):e15568. doi:10.1111/tan.15568
In the article, the Abstract section was inadvertently removed. The Abstract should read:
Abstract
A fundamental endeavor of the International Histocompatibility and Immunogenetics Workshop (IHIW) was assembling a collection of DNA samples homozygous through the MHC genomic region. This collection proved invaluable for assay development in the histocompatibility and immunogenetics field, for generating the human reference genome, and furthered our understanding of MHC diversity. Defined by their HLA-A, -B, -C and -DRB1 alleles, the combined frequency of the haplotypes from these individuals is ~20% in Europe. Thus, a significant proportion of MHC haplotypes, both common and rare throughout the world, and including many associated with disease, are not yet represented. In this workshop component, we are collecting the next generation of MHC-homozygous samples, to expand, diversify and modernize this critical community resource that has been foundational to the field. We asked laboratories worldwide to identify samples homozygous through all HLA class I and/or HLA class II genes, or through whole-genome SNP genotyping or sequencing, to have extensive homozygosity tracts within the MHC region. The focus is non-Europeans or those having HLA haplotypes less common in Europeans. Through this effort, we have obtained samples from 537 individuals representing 294 distinct haplotypes, as determined by their HLA class I and II alleles, and an additional 50 haplotypes distinct in HLA class I or II alleles. Although we have expanded the diversity, many populations remain underrepresented, particularly from Africa, and we encourage further participation. The data will serve as a resource for investigators seeking to characterise variation across the MHC genomic region for disease and population studies.
The abstract has been added to the online version.
期刊介绍：
HLA, the journal, publishes articles on various aspects of immunogenetics. These include the immunogenetics of cell surface antigens, the ontogeny and phylogeny of the immune system, the immunogenetics of cell interactions, the functional aspects of cell surface molecules and their natural ligands, and the role of tissue antigens in immune reactions. Additionally, the journal covers experimental and clinical transplantation, the relationships between normal tissue antigens and tumor-associated antigens, the genetic control of immune response and disease susceptibility, and the biochemistry and molecular biology of alloantigens and leukocyte differentiation. Manuscripts on molecules expressed on lymphoid cells, myeloid cells, platelets, and non-lineage-restricted antigens are welcomed. Lastly, the journal focuses on the immunogenetics of histocompatibility antigens in both humans and experimental animals, including their tissue distribution, regulation, and expression in normal and malignant cells, as well as the use of antigens as markers for disease.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
