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Characterisation of the Novel HLA-DQB1*05:354 Allele by Sequencing-Based Typing
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-06 DOI: 10.1111/tan.70071
Thibault Pajot, Vincent Elsermans, Isabelle Top, Myriam Labalette

HLA-DQB1*05:354 differs from HLA-DQB1*05:01:01:01 by one nucleotide substitution in codon 55 in exon 2.

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引用次数: 0
The Novel HLA-A*02:1195N Null Allele Identified by Next-Generation Sequencing
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-06 DOI: 10.1111/tan.70060
Justine Schmitt, André Gothot

HLA-A*02:1195N differs from HLA-A*02:01:01:01 by one nucleotide substitution in exon 4, at gDNA position 1843 (G>A).

{"title":"The Novel HLA-A*02:1195N Null Allele Identified by Next-Generation Sequencing","authors":"Justine Schmitt,&nbsp;André Gothot","doi":"10.1111/tan.70060","DOIUrl":"https://doi.org/10.1111/tan.70060","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-A*02:1195N differs from HLA-A*02:01:01:01 by one nucleotide substitution in exon 4, at gDNA position 1843 (G&gt;A).</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-A*29:200N Allele by Sequencing-Based Typing
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-06 DOI: 10.1111/tan.70073
Thibault Pajot, Vincent Elsermans, Isabelle Top, Myriam Labalette

HLA-A*29:200N differs from HLA-A*29:02:01:01 by one nucleotide substitution in codon 255 in exon 4.

{"title":"Characterisation of the Novel HLA-A*29:200N Allele by Sequencing-Based Typing","authors":"Thibault Pajot,&nbsp;Vincent Elsermans,&nbsp;Isabelle Top,&nbsp;Myriam Labalette","doi":"10.1111/tan.70073","DOIUrl":"https://doi.org/10.1111/tan.70073","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*29:200N</i> differs from <i>HLA-A*29:02:01:01</i> by one nucleotide substitution in codon 255 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel HLA-B*08:331 Allele Identified by Next-Generation Sequencing
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-05 DOI: 10.1111/tan.70055
Mirzokhid Rakhmanov, Martin Bernheiden, Murielle Verboom, Michael Hallensleben, Florian Emmerich

HLA-B*08:331 differs from HLA-B*08:01:01:01 by a single nucleotide substitution in codon -3 in exon 1.

{"title":"A Novel HLA-B*08:331 Allele Identified by Next-Generation Sequencing","authors":"Mirzokhid Rakhmanov,&nbsp;Martin Bernheiden,&nbsp;Murielle Verboom,&nbsp;Michael Hallensleben,&nbsp;Florian Emmerich","doi":"10.1111/tan.70055","DOIUrl":"10.1111/tan.70055","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-B*08:331 differs from HLA-B*08:01:01:01 by a single nucleotide substitution in codon -3 in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Two Novel Alleles HLA-B*14:136 and HLA-B*58:159 by Next-Generation Sequencing
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-04 DOI: 10.1111/tan.70042
Qingdong Guan, Kristin Jacobson, Aggie Gentile, Hernan Suniga

Two novel HLA-B alleles, HLA-B*14:136 and -B*58:159, identified by NGS during the routine HLA typing.

{"title":"Identification of Two Novel Alleles HLA-B*14:136 and HLA-B*58:159 by Next-Generation Sequencing","authors":"Qingdong Guan,&nbsp;Kristin Jacobson,&nbsp;Aggie Gentile,&nbsp;Hernan Suniga","doi":"10.1111/tan.70042","DOIUrl":"https://doi.org/10.1111/tan.70042","url":null,"abstract":"<div>\u0000 \u0000 <p>Two novel HLA-B alleles, HLA-B*14:136 and -B*58:159, identified by NGS during the routine HLA typing.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143110666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel HLA-DRB3*02:213 Allele by Next-Generation Sequencing
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-04 DOI: 10.1111/tan.70002
Charlène Bouthemy, Jean Milhès, Nicolas Congy-Jolivet

HLA-DRB3*02:213 differs from DRB3*02:02 by one nucleotide substitution in codon 6 in exon 2.

{"title":"Identification of the Novel HLA-DRB3*02:213 Allele by Next-Generation Sequencing","authors":"Charlène Bouthemy,&nbsp;Jean Milhès,&nbsp;Nicolas Congy-Jolivet","doi":"10.1111/tan.70002","DOIUrl":"https://doi.org/10.1111/tan.70002","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DRB3*02:213 differs from DRB3*02:02 by one nucleotide substitution in codon 6 in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection and Quantification of Polymorphic MICA and MICB Molecules in Immunoassays: Initial Insights
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-04 DOI: 10.1111/tan.70039
A. Yu. Stolbovaya, A. A. Pinevich, I. V. Gryazeva, I. Yu. Krutetskaya, G. M. Zharinov, M. A. Morozova, A. Yu. Kneev, L. A. Terekhina, S. A. Ishchuk, O. A. Shashkova, N. L. Vartanian, M. P. Samoylovich, V. F. Bezhenar, D. I. Sokolov, S. A. Selkov, I. V. Smirnov

The MICA and MICB molecules, expressed on the cell membrane in response to cellular stress or cancer transformation, pose significant challenges for immunoassays. They exhibit high sequence and structural similarity, alongside considerable allelic polymorphism, with 291 and 53 known protein sequences, respectively. Some researchers treat MICA and MICB as a unified target because of their structural and functional similarities, while others distinguish between them. However, which approach is superior and under what circumstances remains unknown. Moreover, information about assays' reactivity with MICA and MICB allelic variants is often missing. In this study, we developed 10 monoclonal antibodies (mAbs) and two sandwich ELISAs for the detection and quantification of these molecules. We assembled a panel of recombinant proteins representing the diversity of MICA and MICB in the European population and profiled the reactivities of the mAbs and ELISAs. The performance of these sandwich ELISAs was evaluated using samples from prostate cancer patients and pregnant women experiencing premature rupture of membranes. Our study assessed the impact of MICA and MICB polymorphism on their detection and quantification by immunological methods, providing evidence to support differential or non-differential approaches for their detection.

{"title":"Detection and Quantification of Polymorphic MICA and MICB Molecules in Immunoassays: Initial Insights","authors":"A. Yu. Stolbovaya,&nbsp;A. A. Pinevich,&nbsp;I. V. Gryazeva,&nbsp;I. Yu. Krutetskaya,&nbsp;G. M. Zharinov,&nbsp;M. A. Morozova,&nbsp;A. Yu. Kneev,&nbsp;L. A. Terekhina,&nbsp;S. A. Ishchuk,&nbsp;O. A. Shashkova,&nbsp;N. L. Vartanian,&nbsp;M. P. Samoylovich,&nbsp;V. F. Bezhenar,&nbsp;D. I. Sokolov,&nbsp;S. A. Selkov,&nbsp;I. V. Smirnov","doi":"10.1111/tan.70039","DOIUrl":"https://doi.org/10.1111/tan.70039","url":null,"abstract":"<div>\u0000 \u0000 <p>The MICA and MICB molecules, expressed on the cell membrane in response to cellular stress or cancer transformation, pose significant challenges for immunoassays. They exhibit high sequence and structural similarity, alongside considerable allelic polymorphism, with 291 and 53 known protein sequences, respectively. Some researchers treat MICA and MICB as a unified target because of their structural and functional similarities, while others distinguish between them. However, which approach is superior and under what circumstances remains unknown. Moreover, information about assays' reactivity with MICA and MICB allelic variants is often missing. In this study, we developed 10 monoclonal antibodies (mAbs) and two sandwich ELISAs for the detection and quantification of these molecules. We assembled a panel of recombinant proteins representing the diversity of MICA and MICB in the European population and profiled the reactivities of the mAbs and ELISAs. The performance of these sandwich ELISAs was evaluated using samples from prostate cancer patients and pregnant women experiencing premature rupture of membranes. Our study assessed the impact of MICA and MICB polymorphism on their detection and quantification by immunological methods, providing evidence to support differential or non-differential approaches for their detection.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of the Novel HLA-DQB1*04:104 Allele Using Short- and Long-Read Sequencing Technologies
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-04 DOI: 10.1111/tan.70046
Angela Santos, Victoria Mendes-Oliveira, Romulo Vianna, Luís Cristóvão Porto, Danielle Secco

The novel HLA-DQB1*04:104 allele, first described in an individual from Brazil.

{"title":"Discovery of the Novel HLA-DQB1*04:104 Allele Using Short- and Long-Read Sequencing Technologies","authors":"Angela Santos,&nbsp;Victoria Mendes-Oliveira,&nbsp;Romulo Vianna,&nbsp;Luís Cristóvão Porto,&nbsp;Danielle Secco","doi":"10.1111/tan.70046","DOIUrl":"https://doi.org/10.1111/tan.70046","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>HLA-DQB1*04:104</i> allele, first described in an individual from Brazil.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next Generation Sequencing Reveals A Novel HLA-C Allele, HLA-C*07:1172
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-04 DOI: 10.1111/tan.70054
Mirzokhid Rakhmanov, Martin Bernheiden, Murielle Verboom, Michael Hallensleben, Florian Emmerich

HLA-C*07:1172 differs from HLA-C*07:01:01:01 by a single nucleotide substitution in Codon 7 in Exon 2.

{"title":"Next Generation Sequencing Reveals A Novel HLA-C Allele, HLA-C*07:1172","authors":"Mirzokhid Rakhmanov,&nbsp;Martin Bernheiden,&nbsp;Murielle Verboom,&nbsp;Michael Hallensleben,&nbsp;Florian Emmerich","doi":"10.1111/tan.70054","DOIUrl":"https://doi.org/10.1111/tan.70054","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-C*07:1172 differs from HLA-C*07:01:01:01 by a single nucleotide substitution in Codon 7 in Exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Novel HLA-DQB1*02:01:01:27 Allele Identified by HLA-Targeted HiFi Sequencing in a Chinese Individual
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2025-02-04 DOI: 10.1111/tan.70056
Yankun Li, Yuanli Zhao, Yue Han, Yingjie Chen, Peng Gao

HLA-DQB1*02:01:01:27 differs from HLA-DQB1*02:01:01:01 by the deletion of a single Thymine nucleotide in intron 2.

{"title":"The Novel HLA-DQB1*02:01:01:27 Allele Identified by HLA-Targeted HiFi Sequencing in a Chinese Individual","authors":"Yankun Li,&nbsp;Yuanli Zhao,&nbsp;Yue Han,&nbsp;Yingjie Chen,&nbsp;Peng Gao","doi":"10.1111/tan.70056","DOIUrl":"https://doi.org/10.1111/tan.70056","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQB1*02:01:01:27</i> differs from <i>HLA-DQB1*02:01:01:01</i> by the deletion of a single Thymine nucleotide in intron 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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