Characteristics and clinical significance of tertiary lymphoid structures in OSCC.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2025-02-01 Epub Date: 2024-07-24 DOI:10.1111/odi.15080

Mianfeng Yao, Tianru Yang, Qiulan Li, Xinle Zhang, Ziran Zheng, Jiang Li, Jiajun Huang, Yuanxin Sun, Xing Gao, Changyun Fang

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Abstract

Objectives: This study aimed to investigate the characteristics of tertiary lymphoid structures (TLSs) in oral squamous cell carcinoma (OSCC) and their association with clinical and pathological features.

Materials and methods: 12 TLS-related chemokines in TCGA database were analyzed to investigate the TLSs in OSCC. The density, maturity, and location of TLSs in a large cohort of 189 OSCC patients (114 of which had clinical and prognostic information) were assessed. And the significance between TLSs and clinicopathologic characteristics was analyzed.

Results: Bioinformatics and analysis showed that TLSs were associated with better clinical outcomes in OSCC. Histological staining and analysis showed that the overall survival rate of the high-density group (71/112, 63.4%) was significantly higher (p < 0.0001) than that of the low-density group (41/112, 36.6%), and the high-density group had fewer lymph node metastases (50.0%/68.3%, p = 0.021). And TLSs were divided into 4 types according to the maturity and location. Different types of TLSs are associated with prognosis (OS, p < 0.0001), clinical features (T stage, p = 0.028; degree of differentiation, p = 0.043), and precancerous lesion types (OSF, p = 0.049) of OSCC patients.

Conclusion: TLSs were closely associated with better OSCC prognosis, and a more systematic classification may better guide the formulation of further treatment options.

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OSCC 中三级淋巴结构的特征和临床意义。

研究目的这项研究旨在调查口腔鳞状细胞癌（OSCC）中三级淋巴结构（TLS）的特征及其与临床和病理特征的关联。材料与方法：研究人员分析了TCGA数据库中12种与TLS相关的趋化因子，以调查OSCC中的TLS。材料：研究人员分析了TCGA数据库中12种与TLS相关的趋化因子，并评估了189例OSCC患者（其中114例有临床和预后信息）中TLS的密度、成熟度和位置。并分析了TLS与临床病理特征之间的意义：结果：生物信息学和分析表明，TLS与OSCC较好的临床预后相关。组织学染色和分析表明，高密度组（71/112，63.4%）的总生存率明显更高（p 结论：TLSs与OSCC更好的临床预后密切相关：TLS与更好的OSCC预后密切相关，更系统的分类可更好地指导进一步治疗方案的制定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.