Differential rearing alters Fos in the accumbens core and ventral palidum following reinstatement of cocaine seeking in male Sprague-Dawley rats

IF 3.3 3区心理学 Q1 BEHAVIORAL SCIENCES Pharmacology Biochemistry and Behavior Pub Date : 2024-07-23 DOI:10.1016/j.pbb.2024.173837

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Abstract

Rearing rats in environmental enrichment produces a protective effect when exposed to stimulants, as enriched rats display attenuated cocaine seeking during reinstatement. However, less is known about what changes in the brain are responsible for this protective effect. The current study investigated differences in Fos protein expression following reinstatement of cocaine seeking in differentially reared rats. Rats were reared in either enriched (EC) or impoverished (IC) conditions for 30 days, after which rats self-administered cocaine in 2-h sessions. Following self-administration, rats underwent extinction and cue-induced or cocaine-primed reinstatement of cocaine seeking, brains were extracted, and Fos immunohistochemistry was performed. IC rats sought cocaine significantly more than EC rats during cue-induced reinstatement, and cocaine seeking was positively correlated with Fos expression in the nucleus accumbens core and ventral pallidum. IC rats displayed greater Fos expression than EC rats in the accumbens and ventral pallidum, suggesting a role of these areas in the enrichment-induced protective effect.

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在雄性 Sprague-Dawley 大鼠恢复寻求可卡因的行为后，不同的饲养方式会改变其脑干核心和腹侧髓质中的 Fos。

在富集环境中饲养大鼠会对暴露于兴奋剂的大鼠产生保护作用，因为富集环境中的大鼠在恢复过程中对可卡因的寻求会减弱。然而，人们对这种保护作用是由大脑中的哪些变化引起的还知之甚少。本研究调查了不同饲养条件的大鼠在可卡因寻求行为恢复后 Fos 蛋白表达的差异。大鼠在富养（EC）或贫养（IC）条件下饲养 30 天，之后大鼠以 2 小时为一个时段自我摄取可卡因。自我给药后，对大鼠进行可卡因寻求的消退、线索诱导或可卡因刺激恢复，提取大鼠大脑并进行Fos免疫组化。在线索诱导的复吸过程中，IC大鼠寻找可卡因的次数明显多于EC大鼠，可卡因寻找与伏隔核核心和腹侧苍白球的Fos表达呈正相关。与欧共体大鼠相比，集成电路大鼠在伏隔核和腹侧苍白球中的Fos表达量更高，这表明这些区域在富集诱导的保护作用中发挥了作用。

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来源期刊

Pharmacology Biochemistry and Behavior 医学-行为科学

CiteScore

6.40

自引率

2.80%

发文量

122

审稿时长

38 days

期刊介绍： Pharmacology Biochemistry & Behavior publishes original reports in the areas of pharmacology and biochemistry in which the primary emphasis and theoretical context are behavioral. Contributions may involve clinical, preclinical, or basic research. Purely biochemical or toxicology studies will not be published. Papers describing the behavioral effects of novel drugs in models of psychiatric, neurological and cognitive disorders, and central pain must include a positive control unless the paper is on a disease where such a drug is not available yet. Papers focusing on physiological processes (e.g., peripheral pain mechanisms, body temperature regulation, seizure activity) are not accepted as we would like to retain the focus of Pharmacology Biochemistry & Behavior on behavior and its interaction with the biochemistry and neurochemistry of the central nervous system. Papers describing the effects of plant materials are generally not considered, unless the active ingredients are studied, the extraction method is well described, the doses tested are known, and clear and definite experimental evidence on the mechanism of action of the active ingredients is provided.