Endogenous Fusarium Endophthalmitis after Bone Marrow Transplant: A Case Report and Literature Review.

Q2 Medicine Vision (Switzerland) Pub Date : 2024-07-21 DOI:10.3390/vision8030044

Cindy S Zhao, Karen Wai, Eubee B Koo, Ehsan Rahimy, Prithvi Mruthyunjaya, Vinit B Mahajan, Charles M T DeBoer

{"title":"Endogenous Fusarium Endophthalmitis after Bone Marrow Transplant: A Case Report and Literature Review.","authors":"Cindy S Zhao, Karen Wai, Eubee B Koo, Ehsan Rahimy, Prithvi Mruthyunjaya, Vinit B Mahajan, Charles M T DeBoer","doi":"10.3390/vision8030044","DOIUrl":null,"url":null,"abstract":"Purpose: We aim to present a case of disseminated fusariosis that occurred in the setting of immunosuppression and presented with bilateral endogenous endophthalmitis, along with a literature review of Fusarium endophthalmitis, highlighting management strategies.Observation: A 70-year-old male with acute myeloid leukemia who had recently undergone a bone marrow transplant noted bilateral floaters and decreased vision. He was found to have bilateral Fusarium endophthalmitis, with subsequent evidence of fungemia and fusariosis in his skin and joints. Despite aggressive local and systemic treatment, he succumbed to the disease. Endophthalmitis was initially stabilized with pars plana vitrectomy and intravitreal amphotericin and voriconazole until the patient transitioned to comfort measures. A review of 31 cases demonstrates that outcomes are poor and that the disease must be treated aggressively, often both systemically and surgically.Conclusion: This case highlights the recalcitrance of Fusarium bacteremia and Fusarium endophthalmitis.","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":"8 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270371/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vision (Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/vision8030044","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: We aim to present a case of disseminated fusariosis that occurred in the setting of immunosuppression and presented with bilateral endogenous endophthalmitis, along with a literature review of Fusarium endophthalmitis, highlighting management strategies.

Observation: A 70-year-old male with acute myeloid leukemia who had recently undergone a bone marrow transplant noted bilateral floaters and decreased vision. He was found to have bilateral Fusarium endophthalmitis, with subsequent evidence of fungemia and fusariosis in his skin and joints. Despite aggressive local and systemic treatment, he succumbed to the disease. Endophthalmitis was initially stabilized with pars plana vitrectomy and intravitreal amphotericin and voriconazole until the patient transitioned to comfort measures. A review of 31 cases demonstrates that outcomes are poor and that the disease must be treated aggressively, often both systemically and surgically.

Conclusion: This case highlights the recalcitrance of Fusarium bacteremia and Fusarium endophthalmitis.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

骨髓移植后的内源性眼内镰刀菌病：病例报告与文献综述。

目的：我们旨在介绍一例在免疫抑制情况下发生的播散性镰刀菌病病例，该病例伴有双侧内源性眼内炎，同时还对眼内镰刀菌病进行了文献综述，重点介绍了治疗策略：一位 70 岁的男性急性髓性白血病患者最近接受了骨髓移植，他发现双侧眼球浮动，视力下降。他被发现患有双侧镰刀菌眼内炎，随后皮肤和关节也出现了真菌血症和镰刀菌病。尽管对他进行了积极的局部和全身治疗，他还是因病去世。眼内炎最初是通过玻璃体旁切除术、玻璃体内两性霉素和伏立康唑来稳定病情，直到患者转为舒适治疗。对 31 例病例的回顾表明，治疗效果不佳，必须积极治疗，通常既要全身治疗，又要手术治疗：本病例凸显了镰刀菌菌血症和眼底镰刀菌病的顽固性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊