Metabolic Messengers: itaconate

IF 18.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Nature metabolism Pub Date : 2024-07-26 DOI:10.1038/s42255-024-01092-x
A. F. McGettrick, L. A. Bourner, F. C. Dorsey, L. A. J. O’Neill
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Abstract

The metabolite itaconate has emerged as an important immunoregulator with roles in antibacterial defence, inhibition of inflammation and, more recently, as an inhibitory factor in obesity. Itaconate is one of the most upregulated metabolites in inflammatory macrophages. It is produced owing to the disturbance of the tricarboxylic acid cycle and the diversion of aconitate to itaconate via the enzyme aconitate decarboxylase 1. In immunology, initial studies concentrated on the role of itaconate in inflammatory macrophages where it was shown to be inhibitory, but this has expanded as the impact of itaconate on other cell types is starting to emerge. This review focuses on itaconate as a key immunoregulatory metabolite and describes its diverse mechanisms of action and its many impacts on the immune and inflammatory responses and in cancer. We also examine the clinical relevance of this immunometabolite and its therapeutic potential for immune and inflammatory diseases. McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.

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代谢信使:伊塔康酸
代谢物伊它康酸已成为一种重要的免疫调节因子,在抗菌防御、抑制炎症以及最近作为肥胖症抑制因子方面发挥作用。伊它康酸是炎症巨噬细胞中上调最多的代谢物之一。它的产生是由于三羧酸循环紊乱,并通过醋酸脱羧酶 1 将醋酸转化为伊他康酸。在免疫学方面,最初的研究集中于伊它肯酸在炎症巨噬细胞中的作用,研究表明伊它肯酸具有抑制作用,但随着伊它肯酸对其他细胞类型的影响开始显现,研究范围有所扩大。这篇综述将重点放在作为一种关键免疫调节代谢物的伊他肯酸上,并描述了它的多种作用机制及其对免疫和炎症反应以及癌症的多种影响。我们还研究了这种免疫代谢物的临床意义及其对免疫和炎症疾病的治疗潜力。
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来源期刊
Nature metabolism
Nature metabolism ENDOCRINOLOGY & METABOLISM-
CiteScore
27.50
自引率
2.40%
发文量
170
期刊介绍: Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.
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