Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction

IF 9.2 1区 医学 Q1 PERIPHERAL VASCULAR DISEASE Angiogenesis Pub Date : 2024-07-26 DOI:10.1007/s10456-024-09938-4
Boxian Pang, Guangtong Dong, Tieliang Pang, Xinyao Sun, Xin Liu, Yifeng Nie, Xing Chang
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Abstract

As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by residing between circulating blood and semi-solid tissue. Various stress stimuli can induce endothelial injury, leading to the onset of corresponding diseases in the body. In recent years, the importance of mitochondria in vascular endothelial injury has become increasingly apparent. Mitochondria, as the primary site of cellular aerobic respiration and the organelle for “energy information transfer,” can detect endothelial cell damage by integrating and receiving various external stress signals. The generation of reactive oxygen species (ROS) and mitochondrial dysfunction often determine the evolution of endothelial cell injury towards necrosis or apoptosis. Therefore, mitochondria are closely associated with endothelial cell function, helping to determine the progression of clinical diseases. This article comprehensively reviews the interconnection and pathogenesis of mitochondrial-induced vascular endothelial cell injury in cardiovascular diseases, renal diseases, pulmonary-related diseases, cerebrovascular diseases, and microvascular diseases associated with diabetes. Corresponding therapeutic approaches are also provided. Additionally, strategies for using clinical drugs to treat vascular endothelial injury-based diseases are discussed, aiming to offer new insights and treatment options for the clinical diagnosis of related vascular injuries.

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对血管内皮损伤相关疾病的发病机制和治疗策略的新认识:关注线粒体功能障碍。
作为血管的重要组成部分,内皮细胞驻留在循环血液和半固体组织之间,在维持整体生理功能方面发挥着关键作用。各种应激刺激都会诱发内皮损伤,导致人体出现相应的疾病。近年来,线粒体在血管内皮损伤中的重要性日益凸显。线粒体作为细胞有氧呼吸的主要场所和 "能量信息传递 "的细胞器,可以通过整合和接收各种外部应激信号来检测内皮细胞损伤。活性氧(ROS)的产生和线粒体功能障碍往往决定着内皮细胞损伤向坏死或凋亡的演变。因此,线粒体与内皮细胞功能密切相关,有助于决定临床疾病的进展。本文全面综述了线粒体诱导的血管内皮细胞损伤在心血管疾病、肾脏疾病、肺部相关疾病、脑血管疾病以及糖尿病相关微血管疾病中的相互联系和发病机制。还提供了相应的治疗方法。此外,还讨论了使用临床药物治疗基于血管内皮损伤的疾病的策略,旨在为相关血管损伤的临床诊断提供新的见解和治疗方案。
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来源期刊
Angiogenesis
Angiogenesis PERIPHERAL VASCULAR DISEASE-
CiteScore
21.90
自引率
8.20%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.
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