Prediction of 1 cm dose-equivalent rate on the day after administration of 177Lu-DOTATATE from 111In-somatostatine receptor scintigraphy prior to treatment

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Annals of Nuclear Medicine Pub Date : 2024-07-26 DOI:10.1007/s12149-024-01962-0
Go Takai, Kohei Hanaoka, Keiji Nagano, Tsutomu Okada, Maya Honda, Izumi Komoto
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Abstract

Objective

When patients administered 177Lu-DOTATATE are released or discharged from rooms where radiopharmaceuticals are used, the time required for release or discharge varies across patients. This study investigated whether the amount of radioactivity accumulated on 111In-somatostatine receptor scintigraphy (111In-SRS) performed prior to treatment can predict the 1 cm dose-equivalent rate at a distance of 1 m from the patient on the day after 177Lu-DOTATATE administration.

Methods

Whole-body planar 111In-SRS images were acquired for 21 patients. Pixel values within whole-body and abdominal (35 × 25 cm) regions of interest (ROIs) were converted to radioactivity dose (MBq). The 1 cm dose-equivalent rate (µSv/h) at a distance of 1 m from the patient 18.3 ± 0.5 h after administration of 177Lu-DOTATATE was measured using an ionization survey meter.

Results

The following relationships were observed between the radioactivity on 111In-SRS and the 1 cm dose-equivalent rate on the day after administration of 177Lu-DOTATATE: whole-body ROI: y = 0.16x + 5.01 (r = 0.56, p = 0.009), abdominal ROI: y = 0.27x + 5.13 (r = 0.63, p = 0.002). The regression equations indicate that patients cannot be released or discharged from the radiopharmaceutical room the day after 177Lu-DOTATATE administration if the whole-body and abdominal ROI doses are greater than 81 and 48 MBq, respectively, on 111In-SRS.

Conclusions

The amount of radioactivity accumulated on 111In-SRS may be a predictor of release criteria for patients receiving 177Lu-DOTATATE.

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根据治疗前的111In-索马他汀受体闪烁扫描预测177Lu-DOTATATE治疗后第二天的1厘米剂量当量率。
目的:当使用177Lu-DOTATATE的患者从使用放射性药物的病房出院或出院时,不同患者出院或出院所需的时间各不相同。本研究探讨了治疗前进行的 111In-索马他汀受体闪烁成像(111In-SRS)所积累的放射性量是否能预测 177Lu-DOTATATE 给药后当天距离患者 1 米处的 1 厘米剂量当量率:方法:为 21 名患者采集了全身平面 111In-SRS 图像。将全身和腹部(35 × 25 厘米)感兴趣区(ROI)内的像素值转换为放射性剂量(MBq)。使用电离测量仪测量了施用 177Lu-DOTATATE 18.3 ± 0.5 h 后距离患者 1 m 处的 1 cm 剂量当量率(µSv/h):111In-SRS 上的放射性与 177Lu-DOTATATE 用药后当天 1 厘米剂量当量率之间存在以下关系:全身 ROI:y = 0.16x + 5.01(r = 0.56,p = 0.009),腹部 ROI:y = 0.27x + 5.13(r = 0.63,p = 0.002)。回归方程表明,如果 111In-SRS 的全身和腹部 ROI 剂量分别超过 81 MBq 和 48 MBq,则患者在服用 177Lu-DOTATATE 后的第二天不能出放射治疗室或出院:结论:111In-SRS上累积的放射性量可作为接受177Lu-DOTATATE治疗的患者放疗标准的预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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