Metabolic Regulation in the Induction of Trained Immunity.

IF 7.9 2区 医学 Q1 IMMUNOLOGY Seminars in Immunopathology Pub Date : 2024-07-25 DOI:10.1007/s00281-024-01015-8
Anaisa V Ferreira, Jorge Domínguez-Andrés, Laura M Merlo Pich, Leo A B Joosten, Mihai G Netea
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Abstract

The innate immune system exhibits features of memory, termed trained immunity, which promote faster and more robust responsiveness to heterologous challenges. Innate immune memory is sustained through epigenetic modifications, affecting gene accessibility, and promoting a tailored gene transcription for an enhanced immune response. Alterations in the epigenetic landscape are intertwined with metabolic rewiring. Here, we review the metabolic pathways that underscore the induction and maintenance of trained immunity, including glycolysis, oxidative phosphorylation, the tricarboxylic acid cycle, and amino acid and lipid metabolism. The intricate interplay of these pathways is pivotal for establishing innate immune memory in distinct cellular compartments. We explore in particular the case of resident lung alveolar macrophages. We propose that leveraging the memory of the innate immune system may present therapeutic potential. Specifically, targeting the metabolic programs of innate immune cells is an emerging strategy for clinical interventions, either to boost immune responses in immunosuppressed conditions or to mitigate maladaptive activation in hyperinflammatory diseases.

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训练免疫诱导过程中的代谢调节
先天性免疫系统具有记忆特征,被称为训练有素的免疫力,可促进对异源挑战做出更快、更强的反应。先天性免疫记忆通过表观遗传修饰得以维持,影响基因的可及性,促进基因转录以增强免疫反应。表观遗传结构的改变与新陈代谢的重新布线相互交织。在这里,我们回顾了诱导和维持训练有素的免疫力的代谢途径,包括糖酵解、氧化磷酸化、三羧酸循环以及氨基酸和脂质代谢。这些途径之间错综复杂的相互作用对于在不同细胞区建立先天性免疫记忆至关重要。我们特别探讨了常驻肺泡巨噬细胞的情况。我们提出,利用先天性免疫系统的记忆可能具有治疗潜力。具体来说,针对先天性免疫细胞的新陈代谢程序是一种新兴的临床干预策略,既能增强免疫抑制条件下的免疫反应,也能减轻高炎症性疾病中的不适应性激活。
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来源期刊
Seminars in Immunopathology
Seminars in Immunopathology 医学-病理学
CiteScore
19.80
自引率
2.20%
发文量
69
审稿时长
12 months
期刊介绍: The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.
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