Yi Li, Yu-Peng Liu, Mengying Xu, Weiwei Xu, Feng-Ping Zhang, Mengchun Ye
{"title":"Ni–Al Bimetal-Catalyzed Tertiary C(sp3)–H Activation for Dual C–H Annulation of Formamides with Alkynes","authors":"Yi Li, Yu-Peng Liu, Mengying Xu, Weiwei Xu, Feng-Ping Zhang, Mengchun Ye","doi":"10.31635/ccschem.024.202404549","DOIUrl":null,"url":null,"abstract":"<p>3d-Metal-catalyzed tertiary C(sp<sup>3</sup>)–H bond activation has been a formidable challenge. Herein, a tertiary C(sp<sup>3</sup>)–H bond is smoothly activated by Ni–Al bimetallic catalysts for dual C–H annulation of formamides with alkynes, delivering a series of δ-lactams with a quaternary carbon up to 98% yield. Various tertiary C(sp<sup>3</sup>)–H bonds such as noncyclic, monocyclic and bridged-ring tertiary C(sp<sup>3</sup>)–H bonds are all compatible with the reaction.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"87 1","pages":""},"PeriodicalIF":9.4000,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CCS Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31635/ccschem.024.202404549","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
3d-Metal-catalyzed tertiary C(sp3)–H bond activation has been a formidable challenge. Herein, a tertiary C(sp3)–H bond is smoothly activated by Ni–Al bimetallic catalysts for dual C–H annulation of formamides with alkynes, delivering a series of δ-lactams with a quaternary carbon up to 98% yield. Various tertiary C(sp3)–H bonds such as noncyclic, monocyclic and bridged-ring tertiary C(sp3)–H bonds are all compatible with the reaction.
期刊介绍：
CCS Chemistry, the flagship publication of the Chinese Chemical Society, stands as a leading international chemistry journal based in China. With a commitment to global outreach in both contributions and readership, the journal operates on a fully Open Access model, eliminating subscription fees for contributing authors. Issued monthly, all articles are published online promptly upon reaching final publishable form. Additionally, authors have the option to expedite the posting process through Immediate Online Accepted Article posting, making a PDF of their accepted article available online upon journal acceptance.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
