Compounds with two axial chiralities are highly valuable yet synthetically challenging targets. We disclose a chiral phosphoric acid (CPA)-catalyzed atroposelective Paal-Knorr reaction that enables the direct construction of chiral diaryl ethers featuring two distinct axial chiralities, including a C-N axis. This operationally simple protocol delivers both diastereomers in high combined yield (up to 91%) and excellent enantiopurities (up to 96% ee and 99% ee, respectively). A proposed CPA-dimer catalytic model accounts for the observed stereoselectivity. The scalability of the process and successful product derivatizations highlight the method‘s practicality and the potential of these diaxially chiral skeletons in catalysis.
{"title":"Simultaneous Control of Dual Axial Chirality: Chiral Phosphoric Acid-Catalyzed Atroposelective Synthesis of Diaryl Ethers","authors":"Pengyang Wang, Xiaoyu Chen, Linlong Dai, Lin Fan, Chang He, Hongda Qiu, Daokai Xiong, Xiaofei Zeng, Wanbin Zhang, Guofu Zhong","doi":"10.31635/ccschem.025.202507266","DOIUrl":"https://doi.org/10.31635/ccschem.025.202507266","url":null,"abstract":"Compounds with two axial chiralities are highly valuable yet synthetically challenging targets. We disclose a chiral phosphoric acid (CPA)-catalyzed atroposelective Paal-Knorr reaction that enables the direct construction of chiral diaryl ethers featuring two distinct axial chiralities, including a C-N axis. This operationally simple protocol delivers both diastereomers in high combined yield (up to 91%) and excellent enantiopurities (up to 96% <i>ee</i> and 99% <i>ee</i>, respectively). A proposed CPA-dimer catalytic model accounts for the observed stereoselectivity. The scalability of the process and successful product derivatizations highlight the method‘s practicality and the potential of these diaxially chiral skeletons in catalysis.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"52 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147496340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-18DOI: 10.31635/ccschem.025.202507280
Tao Hai, Shen Zhang, Yunqi Liu, Derong Kong, Dacheng Wei
Organic transistors hold great promise for implantable applications in personalized health monitoring and precise therapy because of their light weight, mechanical compatibility with soft tissues and tunable electrical properties. From single devices to complicated circuits, recent years have witnessed the rapid development of devices with various structures for innovative implantable applications. The types and working mechanisms of organic transistors, as well as the properties necessary for implantable applications are reviewed. The latest advances and representative applications of implantable organic transistors are summarized and analyzed, with a perspective for future development.
{"title":"Implantable Organic Transistors: Architectures, Properties and Applications","authors":"Tao Hai, Shen Zhang, Yunqi Liu, Derong Kong, Dacheng Wei","doi":"10.31635/ccschem.025.202507280","DOIUrl":"https://doi.org/10.31635/ccschem.025.202507280","url":null,"abstract":"Organic transistors hold great promise for implantable applications in personalized health monitoring and precise therapy because of their light weight, mechanical compatibility with soft tissues and tunable electrical properties. From single devices to complicated circuits, recent years have witnessed the rapid development of devices with various structures for innovative implantable applications. The types and working mechanisms of organic transistors, as well as the properties necessary for implantable applications are reviewed. The latest advances and representative applications of implantable organic transistors are summarized and analyzed, with a perspective for future development.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"60 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The continuous transmission and amplification of chirality is a fascinating feature in natural biological systems. However, achieving sequential transmission of circularly polarized luminescence (CPL) through multistep energy transfer remains a formidable challenge. Here, chiral N-heterocyclic carbene-protected Cu3 clusters (R/S-Cu3) were synthesized as light-harvesting antennas, self-assembling into blue-emitting nanospheres with considerable CPL-active. Coumarin 6 (C-6), a green emitter, was introduced as key relay baton for both chirality and energy transmission. We constructed chiral light-harvesting systems (LHSs) through the co-assembly of R/S-Cu3, C-6, and red-emitting Nile Red (NiR), enabling efficient two-step energy transfer with a maximum efficiency (ΦET, max) of 87.86%. Supramolecular engineering was employed to fabricate nanofiber bundles serving as film-templates, which facilitates sequential CPL transmission from Cu3 to C-6 and subsequently to NiR. The sequential circularly polarized Forster resonance energy transfer (CP-FRET) was verified via CPL spectral comparisons, resulting in distinct amplification of the dissymmetry factor. This work develops metal clusters-driven sequential CPL and energy transmission in chiral LHSs and provides in-depth insights into CPFRET mechanism.
{"title":"Chiral Copper Clusters as Artificial Light-Harvesting Antennas Enabling Sequential Circularly Polarized Fürster Resonance Energy Transfer","authors":"Tian-Li Gao, Qi-Xiang Cai, Xiao-Jie Xu, Shuai-Peng Chen, Li-Zhen Wang, Ying-Xue Yuan, Shuang-Quan Zang","doi":"10.31635/ccschem.025.202507344","DOIUrl":"https://doi.org/10.31635/ccschem.025.202507344","url":null,"abstract":"The continuous transmission and amplification of chirality is a fascinating feature in natural biological systems. However, achieving sequential transmission of circularly polarized luminescence (CPL) through multistep energy transfer remains a formidable challenge. Here, chiral N-heterocyclic carbene-protected Cu<sub>3</sub> clusters (<i>R/S</i>-Cu<sub>3</sub>) were synthesized as light-harvesting antennas, self-assembling into blue-emitting nanospheres with considerable CPL-active. Coumarin 6 (C-6), a green emitter, was introduced as key relay baton for both chirality and energy transmission. We constructed chiral light-harvesting systems (LHSs) through the co-assembly of <i>R/S</i>-Cu<sub>3</sub>, C-6, and red-emitting Nile Red (NiR), enabling efficient two-step energy transfer with a maximum efficiency (Φ<sub>ET</sub>, max) of 87.86%. Supramolecular engineering was employed to fabricate nanofiber bundles serving as film-templates, which facilitates sequential CPL transmission from Cu<sub>3</sub> to C-6 and subsequently to NiR. The sequential circularly polarized Forster resonance energy transfer (CP-FRET) was verified via CPL spectral comparisons, resulting in distinct amplification of the dissymmetry factor. This work develops metal clusters-driven sequential CPL and energy transmission in chiral LHSs and provides in-depth insights into CPFRET mechanism.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"41 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ferroelectric materials with unique spontaneous polarization and ferroelectric domains have drawn growing academic focus as novel catalytic candidates in recent years, owing to their distinctive ability to regulate charge carrier behavior. The spontaneous polarization forms a built-in electric field to promote the separation of charge carriers, and polarization modulation triggered by external stimuli induces the release of free charges from the ferroelectric domain surface, which expedites the progression of redox reactions. In contrast to widely used inorganic ferroelectrics, molecular ferroelectrics hold prominent advantages, such as the low acoustic impedance that facilitates efficient mechanical energy transmission from solvent to catalyst, and the solvent solubility that enables good catalyst recyclability. Such traits make them highly prospective for advancing efficient and sustainable ferroelectric catalysis. This minireview summarizes recent advances in molecular ferroelectric catalysis. The principle of ferroelectric catalysis and the advantages of molecular ferroelectric catalysis are first outlined. The recent progress in molecular ferroelectric catalysis, including catalytic quinoline annulation, olefin difunctionalization, alkane oxidation, alkyne coupling, and hydrogen production, was then presented, which shows much better catalytic performance than that of inorganic counterparts. Finally, the challenges, opportunities, and perspectives within the field are discussed to inspire future research studies into molecular ferroelectric catalysis.
{"title":"Molecular Ferroelectric Catalysis","authors":"Jun-Chao Qi, Lutao Li, Huihui Hu, Xiao-Gang Chen, Chen-Kai Yang, Huan-Huan Chen, Yan Qin, Wei-Qiang Liao, Guifu Zou, Yu-Meng You, Ren-Gen Xiong","doi":"10.31635/ccschem.026.202607396","DOIUrl":"https://doi.org/10.31635/ccschem.026.202607396","url":null,"abstract":"Ferroelectric materials with unique spontaneous polarization and ferroelectric domains have drawn growing academic focus as novel catalytic candidates in recent years, owing to their distinctive ability to regulate charge carrier behavior. The spontaneous polarization forms a built-in electric field to promote the separation of charge carriers, and polarization modulation triggered by external stimuli induces the release of free charges from the ferroelectric domain surface, which expedites the progression of redox reactions. In contrast to widely used inorganic ferroelectrics, molecular ferroelectrics hold prominent advantages, such as the low acoustic impedance that facilitates efficient mechanical energy transmission from solvent to catalyst, and the solvent solubility that enables good catalyst recyclability. Such traits make them highly prospective for advancing efficient and sustainable ferroelectric catalysis. This minireview summarizes recent advances in molecular ferroelectric catalysis. The principle of ferroelectric catalysis and the advantages of molecular ferroelectric catalysis are first outlined. The recent progress in molecular ferroelectric catalysis, including catalytic quinoline annulation, olefin difunctionalization, alkane oxidation, alkyne coupling, and hydrogen production, was then presented, which shows much better catalytic performance than that of inorganic counterparts. Finally, the challenges, opportunities, and perspectives within the field are discussed to inspire future research studies into molecular ferroelectric catalysis.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"3 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.31635/ccschem.025.202507261
Luxin Sun, Changhui Dai, Yucheng Guo, Sheng Guo
Liquid alkanes constitute the dominant components of petroleum-derived streams and serve as key intermediates in refining and chemical manufacturing, making their efficient separation a central yet challenging task in chemical processing. However, the separation of liquid alkanes has long relied on thermodynamically driven phase-change operations, such as distillation and rectification, which inherently couple separation efficiency with high energy consumption and limited molecularlevel selectivity. These limitations become particularly pronounced when molecular-level discrimination among structurally similar alkanes is required. In this context, non-phase-change membrane separation provides an alternative pathway by enabling selective transport of liquid alkanes without vapor-liquid transitions. Recent advances in membrane chemistry have demonstrated that separation performance can be regulated through separation mechanisms, polymer architecture design, and solvation-transport coupling. This Mini Review summarizes recent progress in non-phase-change membrane separation of liquid alkanes, with emphasis on underlying separation mechanisms, representative materials design strategies, and emerging perspectives. These insights provide a mechanistic framework for understanding liquid alkane separation beyond conventional phase-change processes and highlight potential opportunities for further advancing efficient hydrocarbon separation, including through the integration of data-driven and artificial-intelligence-assisted approaches.
{"title":"Non-Phase-Change Membrane Separation of Liquid Alkanes: Mechanisms, Materials Design, and Emerging Perspectives","authors":"Luxin Sun, Changhui Dai, Yucheng Guo, Sheng Guo","doi":"10.31635/ccschem.025.202507261","DOIUrl":"https://doi.org/10.31635/ccschem.025.202507261","url":null,"abstract":"Liquid alkanes constitute the dominant components of petroleum-derived streams and serve as key intermediates in refining and chemical manufacturing, making their efficient separation a central yet challenging task in chemical processing. However, the separation of liquid alkanes has long relied on thermodynamically driven phase-change operations, such as distillation and rectification, which inherently couple separation efficiency with high energy consumption and limited molecularlevel selectivity. These limitations become particularly pronounced when molecular-level discrimination among structurally similar alkanes is required. In this context, non-phase-change membrane separation provides an alternative pathway by enabling selective transport of liquid alkanes without vapor-liquid transitions. Recent advances in membrane chemistry have demonstrated that separation performance can be regulated through separation mechanisms, polymer architecture design, and solvation-transport coupling. This Mini Review summarizes recent progress in non-phase-change membrane separation of liquid alkanes, with emphasis on underlying separation mechanisms, representative materials design strategies, and emerging perspectives. These insights provide a mechanistic framework for understanding liquid alkane separation beyond conventional phase-change processes and highlight potential opportunities for further advancing efficient hydrocarbon separation, including through the integration of data-driven and artificial-intelligence-assisted approaches.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"20 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.31635/ccschem.026.202507120
Jie Kong, Qingxi Zhai, Fangming Zhao, Linlin Zeng, Xu Liu, Yan Zhu, Yi Luo, Meng Zhou
Atomic-level doping while preserving structural integrity is a powerful approach for tailoring nanocluster properties. In this study, we investigate Pd-doped Au38 nanoclusters, Pd1Au37 and Pd2Au36, in which Pd atoms are selectively introduced into the central sites of the bi-icosahedral core while preserving the global framework. This isostructural system enables precise modulation of electronic structure and vibrational behavior. Theoretical calculations reveal that Pd substitution significantly redistributes electron and hole densities and narrows the highest occupied molecular orbital–lowest unoccupied molecular orbital gap, in contrast to the parent Au38 nanocluster. Ultrafast transient absorption spectroscopy shows dramatic changes in excited-state dynamics, including a three-orders-of-magnitude increase in lifetime for Pd1Au37 in nitrogenous solvents. Coherent vibrational analyses, corroborated by steady-state Raman spectroscopy, uncovers a distinct evolution of lattice dynamics: while Au38 and Pd2Au36 exhibit single vibrational modes at 0.8 and 1.7 THz respectively, Pd1Au37 uniquely exhibits dual modes, reflecting enhanced coupling and vibrational complexity. The results demonstrate that isostructural doping serves as an effective strategy for tailoring electronic and vibrational properties at the atomic scale.
{"title":"Tailoring Electronic and Vibrational Properties in Isostructural Metal Nanoclusters","authors":"Jie Kong, Qingxi Zhai, Fangming Zhao, Linlin Zeng, Xu Liu, Yan Zhu, Yi Luo, Meng Zhou","doi":"10.31635/ccschem.026.202507120","DOIUrl":"https://doi.org/10.31635/ccschem.026.202507120","url":null,"abstract":"Atomic-level doping while preserving structural integrity is a powerful approach for tailoring nanocluster properties. In this study, we investigate Pd-doped Au<sub>38</sub> nanoclusters, Pd<sub>1</sub>Au<sub>37</sub> and Pd<sub>2</sub>Au<sub>36</sub>, in which Pd atoms are selectively introduced into the central sites of the bi-icosahedral core while preserving the global framework. This isostructural system enables precise modulation of electronic structure and vibrational behavior. Theoretical calculations reveal that Pd substitution significantly redistributes electron and hole densities and narrows the highest occupied molecular orbital–lowest unoccupied molecular orbital gap, in contrast to the parent Au<sub>38</sub> nanocluster. Ultrafast transient absorption spectroscopy shows dramatic changes in excited-state dynamics, including a three-orders-of-magnitude increase in lifetime for Pd<sub>1</sub>Au<sub>37</sub> in nitrogenous solvents. Coherent vibrational analyses, corroborated by steady-state Raman spectroscopy, uncovers a distinct evolution of lattice dynamics: while Au<sub>38</sub> and Pd<sub>2</sub>Au<sub>36</sub> exhibit single vibrational modes at 0.8 and 1.7 THz respectively, Pd<sub>1</sub>Au<sub>37</sub> uniquely exhibits dual modes, reflecting enhanced coupling and vibrational complexity. The results demonstrate that isostructural doping serves as an effective strategy for tailoring electronic and vibrational properties at the atomic scale.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"15 1","pages":"1-14"},"PeriodicalIF":11.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147440297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.31635/ccschem.025.202506995
Jiang-Pei Yuan, Zong-Jie Guan, Wen-Ting Li, Ling Yuan, Hang Xing, Abdullah M. Al-Enizi, Ayman Nafady, He Zheng, Shengqian Ma, Yu Fang
Designing energy-storage materials that mimic the light-dark coupling mechanism of natural photosynthesis represents a key challenge in the field of energy conversion. Current catalysts for photoelectrocatalytic applications, namely semiconductors, metal-organic frameworks (MOFs), and organic photocatalysts, display material-specific inherent limitations. In this study, we developed a series of porous coordination cages (PCCs), designated as <b xmlns:bkstg="http://www.atypon.com/backstage-ns" xmlns:fn="http://www.w3.org/2005/xpath-functions" xmlns:pxje="java:com.atypon.frontend.services.impl.PassportXslJavaExtentions" xmlns:urlutil="java:com.atypon.literatum.customization.UrlUtil" xmlns:xlink="http://www.w3.org/1999/xlink"> <bold>PCC-X</bold></b> (where X=6, 7, 8), that exhibited extremely rare photochargeable property, which can accelerate a variety of reactions in the post-irradiation dark period. In the irradiation period, PCC activates the C(sp<sup>3</sup>)-H bonds of hydrocarbons, rapidly generating hydroperoxides and stored the energy there, forming <b xmlns:bkstg="http://www.atypon.com/backstage-ns" xmlns:fn="http://www.w3.org/2005/xpath-functions" xmlns:pxje="java:com.atypon.frontend.services.impl.PassportXslJavaExtentions" xmlns:urlutil="java:com.atypon.literatum.customization.UrlUtil" xmlns:xlink="http://www.w3.org/1999/xlink"> <bold>THF-OOH@PCC-X</bold></b>. With the sulfur atom in the phenothiazine core of the <b xmlns:bkstg="http://www.atypon.com/backstage-ns" xmlns:fn="http://www.w3.org/2005/xpath-functions" xmlns:pxje="java:com.atypon.frontend.services.impl.PassportXslJavaExtentions" xmlns:urlutil="java:com.atypon.literatum.customization.UrlUtil" xmlns:xlink="http://www.w3.org/1999/xlink"> <bold>PCC-6</bold></b> gradually oxidized to sulfoxide (<b xmlns:bkstg="http://www.atypon.com/backstage-ns" xmlns:fn="http://www.w3.org/2005/xpath-functions" xmlns:pxje="java:com.atypon.frontend.services.impl.PassportXslJavaExtentions" xmlns:urlutil="java:com.atypon.literatum.customization.UrlUtil" xmlns:xlink="http://www.w3.org/1999/xlink"> <bold>PCC-7</bold></b>) and sulfone (<b xmlns:bkstg="http://www.atypon.com/backstage-ns" xmlns:fn="http://www.w3.org/2005/xpath-functions" xmlns:pxje="java:com.atypon.frontend.services.impl.PassportXslJavaExtentions" xmlns:urlutil="java:com.atypon.literatum.customization.UrlUtil" xmlns:xlink="http://www.w3.org/1999/xlink"> <bold>PCC-8</bold></b>), the latter exhibited superior oxidation properties, thanks to its highest positive valence band value. In the dark period, <b xmlns:bkstg="http://www.atypon.com/backstage-ns" xmlns:fn="http://www.w3.org/2005/xpath-functions" xmlns:pxje="java:com.atypon.frontend.services.impl.PassportXslJavaExtentions" xmlns:urlutil="java:com.atypon.literatum.customization.UrlUtil" xmlns:xlink="http://www.w3.org/1999/xlink"> <bold>THF-OOH@PCC-8</bold></b> not only catalyzes the formation of C-S, O-S, S-S, and N-S bonds, but also facilitates the rapid detoxification of a real chemical
设计模拟自然光合作用的光暗耦合机制的储能材料是能量转换领域的一个关键挑战。目前用于光电催化应用的催化剂，即半导体、金属有机框架（MOFs）和有机光催化剂，显示出特定材料的固有局限性。在本研究中，我们开发了一系列多孔配位笼（PCCs），命名为PCCs -X（其中X= 6,7,8），具有极其罕见的光充电特性，可以加速辐照后黑暗期的各种反应。在辐照期间，PCC激活碳氢化合物的C(sp3)-H键，迅速生成氢过氧化物并将能量储存在那里，形成THF-OOH@PCC-X。随着PCC-6吩噻嗪核心的硫原子逐渐氧化为亚砜（PCC-7）和砜（PCC-8），后者由于其正价带值最高而表现出优异的氧化性能。在暗期，THF-OOH@PCC-8不仅催化了C-S、O-S、S-S和N-S键的形成，而且还促进了一种真正的化学武器剂（o -乙基- s -[2-（二异丙基氨基）乙基]甲基膦硫酸盐，VX）的快速解毒。这项工作引入了第一个能够耦合光和暗反应的分子笼，提供了一种通过在异常活跃的物种中有效储存光能来模拟光合作用的新方法。
{"title":"Hydroperoxide-Mediated Photochargeable Molecular Cage for Post-Irradiation Dark Catalysis","authors":"Jiang-Pei Yuan, Zong-Jie Guan, Wen-Ting Li, Ling Yuan, Hang Xing, Abdullah M. Al-Enizi, Ayman Nafady, He Zheng, Shengqian Ma, Yu Fang","doi":"10.31635/ccschem.025.202506995","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506995","url":null,"abstract":"Designing energy-storage materials that mimic the light-dark coupling mechanism of natural photosynthesis represents a key challenge in the field of energy conversion. Current catalysts for photoelectrocatalytic applications, namely semiconductors, metal-organic frameworks (MOFs), and organic photocatalysts, display material-specific inherent limitations. In this study, we developed a series of porous coordination cages (PCCs), designated as <b xmlns:bkstg=\"http://www.atypon.com/backstage-ns\" xmlns:fn=\"http://www.w3.org/2005/xpath-functions\" xmlns:pxje=\"java:com.atypon.frontend.services.impl.PassportXslJavaExtentions\" xmlns:urlutil=\"java:com.atypon.literatum.customization.UrlUtil\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">\u0000<bold>PCC-X</bold></b> (where X=6, 7, 8), that exhibited extremely rare photochargeable property, which can accelerate a variety of reactions in the post-irradiation dark period. In the irradiation period, PCC activates the C(sp<sup>3</sup>)-H bonds of hydrocarbons, rapidly generating hydroperoxides and stored the energy there, forming <b xmlns:bkstg=\"http://www.atypon.com/backstage-ns\" xmlns:fn=\"http://www.w3.org/2005/xpath-functions\" xmlns:pxje=\"java:com.atypon.frontend.services.impl.PassportXslJavaExtentions\" xmlns:urlutil=\"java:com.atypon.literatum.customization.UrlUtil\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">\u0000<bold>THF-OOH@PCC-X</bold></b>. With the sulfur atom in the phenothiazine core of the <b xmlns:bkstg=\"http://www.atypon.com/backstage-ns\" xmlns:fn=\"http://www.w3.org/2005/xpath-functions\" xmlns:pxje=\"java:com.atypon.frontend.services.impl.PassportXslJavaExtentions\" xmlns:urlutil=\"java:com.atypon.literatum.customization.UrlUtil\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">\u0000<bold>PCC-6</bold></b> gradually oxidized to sulfoxide (<b xmlns:bkstg=\"http://www.atypon.com/backstage-ns\" xmlns:fn=\"http://www.w3.org/2005/xpath-functions\" xmlns:pxje=\"java:com.atypon.frontend.services.impl.PassportXslJavaExtentions\" xmlns:urlutil=\"java:com.atypon.literatum.customization.UrlUtil\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">\u0000<bold>PCC-7</bold></b>) and sulfone (<b xmlns:bkstg=\"http://www.atypon.com/backstage-ns\" xmlns:fn=\"http://www.w3.org/2005/xpath-functions\" xmlns:pxje=\"java:com.atypon.frontend.services.impl.PassportXslJavaExtentions\" xmlns:urlutil=\"java:com.atypon.literatum.customization.UrlUtil\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">\u0000<bold>PCC-8</bold></b>), the latter exhibited superior oxidation properties, thanks to its highest positive valence band value. In the dark period, <b xmlns:bkstg=\"http://www.atypon.com/backstage-ns\" xmlns:fn=\"http://www.w3.org/2005/xpath-functions\" xmlns:pxje=\"java:com.atypon.frontend.services.impl.PassportXslJavaExtentions\" xmlns:urlutil=\"java:com.atypon.literatum.customization.UrlUtil\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">\u0000<bold>THF-OOH@PCC-8</bold></b> not only catalyzes the formation of C-S, O-S, S-S, and N-S bonds, but also facilitates the rapid detoxification of a real chemical","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"100 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.31635/ccschem.026.202507155
Maximillian G. Stanzione, Oxana V. Magdysyuk, Daniel J. M. Irving, Chinnasamy Murugesan, Nicole L. Kelly, Yingling Liao, Pech Thongkam, Heitor S. Seleghini, Paul S. Wheatley, David B. Cordes, Simon J. Coles, Daniel N. Rainer, Aamod V. Desai, Sharon E. Ashbrook, Julia L. Payne, Russell E. Morris, A. Robert Armstrong
Organic anode materials for sodium-ion batteries are attracting a great deal of interest due to their sustainability and design flexibility. However, the Na+ insertion mechanism is poorly understood, especially for disordered organic anode materials. A lack of understanding restricts optimization efforts and potential commercialization. Herein, we apply a range of characterization techniques, such as three-dimensional electron diffraction, powder X-ray diffraction, Raman spectroscopy, electron paramagnetic resonance spectroscopy, and pair distribution function (PDF) analysis to a model system, sodium naphthalene-2,6-dicarboxylate, to elucidate the Na+ storage mechanism. A combined ab initio random structure search and PDF study was conducted to postulate a structure of sodiated Na2+xNDC (s-NDC). Our work reveals an expansion in the Na+–O storage layer to allow for the accommodation of inserted Na+. Meanwhile, the naphthalene units exist as radical species, promoting a reorientation to accommodate the inserted Na+, as well as facilitating a stabilizing π interaction. Ultimately, our results illustrate the efficacy of using a multi-technique approach to study the sodiation mechanism of an organic anode material and offer insight into the sodiated structure. This approach can inform the strategic molecular design of future organic anode materials.
{"title":"Elucidating the Sodium Insertion Mechanism of an Organic Electrode Material for Sodium-Ion Batteries","authors":"Maximillian G. Stanzione, Oxana V. Magdysyuk, Daniel J. M. Irving, Chinnasamy Murugesan, Nicole L. Kelly, Yingling Liao, Pech Thongkam, Heitor S. Seleghini, Paul S. Wheatley, David B. Cordes, Simon J. Coles, Daniel N. Rainer, Aamod V. Desai, Sharon E. Ashbrook, Julia L. Payne, Russell E. Morris, A. Robert Armstrong","doi":"10.31635/ccschem.026.202507155","DOIUrl":"https://doi.org/10.31635/ccschem.026.202507155","url":null,"abstract":"Organic anode materials for sodium-ion batteries are attracting a great deal of interest due to their sustainability and design flexibility. However, the Na<sup>+</sup> insertion mechanism is poorly understood, especially for disordered organic anode materials. A lack of understanding restricts optimization efforts and potential commercialization. Herein, we apply a range of characterization techniques, such as three-dimensional electron diffraction, powder X-ray diffraction, Raman spectroscopy, electron paramagnetic resonance spectroscopy, and pair distribution function (PDF) analysis to a model system, sodium naphthalene-2,6-dicarboxylate, to elucidate the Na<sup>+</sup> storage mechanism. A combined ab initio random structure search and PDF study was conducted to postulate a structure of sodiated Na<sub>2+<i>x</i></sub>NDC (s-NDC). Our work reveals an expansion in the Na<sup>+</sup>–O storage layer to allow for the accommodation of inserted Na<sup>+</sup>. Meanwhile, the naphthalene units exist as radical species, promoting a reorientation to accommodate the inserted Na<sup>+</sup>, as well as facilitating a stabilizing π interaction. Ultimately, our results illustrate the efficacy of using a multi-technique approach to study the sodiation mechanism of an organic anode material and offer insight into the sodiated structure. This approach can inform the strategic molecular design of future organic anode materials.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"212 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report herein an efficient palladium-catalyzed method for the construction of four- to eight-membered rings, including benzocyclobutene, indole, indene, indanone, naphthalene, phenanthrene, azepine, and azocine cores, on the aryl moiety of unstrained aryl ketones via C–C cleavage as the key step. A variety of cyclization products were synthesized with excellent functional-group tolerance and high regioselectivity, especially for unsymmetrical alkynes. The late-stage diversification of a series of natural products and pharmaceuticals highlights the synthetic utility of this methodology. Furthermore, multiple dehydroabietic acid-based derivatives were successfully constructed, leading to the rapid identification of several molecules with significantly enhanced antimicrobial activity.
{"title":"Late-Stage Cyclization of Natural Products and Drug Molecules Enabled by C–C Bond Cleavage of Aryl Ketones","authors":"Xing Wang, Yu-Xi Li, Qing-Ying Zeng, Xin-Ming Yu, Tian-Qi Gao, Huan Liu, Ling-Xia Zhang, Hui Xu, Zhen-Yu Wang, Lefu Lan, Hui-Xiong Dai","doi":"10.31635/ccschem.026.202507090","DOIUrl":"https://doi.org/10.31635/ccschem.026.202507090","url":null,"abstract":"We report herein an efficient palladium-catalyzed method for the construction of four- to eight-membered rings, including benzocyclobutene, indole, indene, indanone, naphthalene, phenanthrene, azepine, and azocine cores, on the aryl moiety of unstrained aryl ketones via C–C cleavage as the key step. A variety of cyclization products were synthesized with excellent functional-group tolerance and high regioselectivity, especially for unsymmetrical alkynes. The late-stage diversification of a series of natural products and pharmaceuticals highlights the synthetic utility of this methodology. Furthermore, multiple dehydroabietic acid-based derivatives were successfully constructed, leading to the rapid identification of several molecules with significantly enhanced antimicrobial activity.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"19 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147440267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.31635/ccschem.026.202607341
Qingqing Zou, Bin Du, Jiayu Sun, Xiaohai Yang, Kemin Wang, Qing Wang
Nanoscale distribution of mesenchymal-to-epithelial transition factor (Met) on the cell surface is essential for intracellular signaling and cell behavior. Met oligomerization activates cell behavior, and ligand spacing is crucial to this activation mechanism. However, the optimal spatial distance for Met oligomerization-mediated activation remains unknown, hindering the design of related cellular function modulators. Herein, based on the programmability of aptamers, β-cyclodextrin (β-CD)-mediated DNA nano-modulators with different ligand spacings were designed to dynamically modulate the lateral distance between receptors on cell membranes, studying the effects of ligand distances on Met oligomerization activation. Four HCR-based DNA nano-modulators (S-HCR18/28/44/60) with 18–60 bp spacings were self-assembled via complementary base pairing. The results showed that DNA nano-modulators with 28- and 44- bp spacings were most effective in activating Met. This regulation was also designed to be reversible via competitive displacement of β-CD. For example, reversible Met activation was achieved using adamantane (Ada) to displace S-HCR28 and S-HCR44. Additionally, the four DNA nano-modulators had varying efficacy in repairing acetaminophen-induced liver injury, with S-HCR28 and S-HCR44 being more effective. This work could guide the design of efficient cellular receptor modulators and offer spatial distance insights for cell biology.
{"title":"Controlled Regulation of Cell Membrane Receptor Activation Using Programmable DNA Nano-modulators and Host–Guest Interactions","authors":"Qingqing Zou, Bin Du, Jiayu Sun, Xiaohai Yang, Kemin Wang, Qing Wang","doi":"10.31635/ccschem.026.202607341","DOIUrl":"https://doi.org/10.31635/ccschem.026.202607341","url":null,"abstract":"Nanoscale distribution of mesenchymal-to-epithelial transition factor (Met) on the cell surface is essential for intracellular signaling and cell behavior. Met oligomerization activates cell behavior, and ligand spacing is crucial to this activation mechanism. However, the optimal spatial distance for Met oligomerization-mediated activation remains unknown, hindering the design of related cellular function modulators. Herein, based on the programmability of aptamers, β-cyclodextrin (β-CD)-mediated DNA nano-modulators with different ligand spacings were designed to dynamically modulate the lateral distance between receptors on cell membranes, studying the effects of ligand distances on Met oligomerization activation. Four HCR-based DNA nano-modulators (S-HCR18/28/44/60) with 18–60 bp spacings were self-assembled via complementary base pairing. The results showed that DNA nano-modulators with 28- and 44- bp spacings were most effective in activating Met. This regulation was also designed to be reversible via competitive displacement of β-CD. For example, reversible Met activation was achieved using adamantane (Ada) to displace S-HCR28 and S-HCR44. Additionally, the four DNA nano-modulators had varying efficacy in repairing acetaminophen-induced liver injury, with S-HCR28 and S-HCR44 being more effective. This work could guide the design of efficient cellular receptor modulators and offer spatial distance insights for cell biology.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"1 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：