Iu. A. Koroleva, I. A. Goncharova, A. A. Zarubin, S. A. Shipulina, A. A. Sleptsov, D. S. Panfilov, B. N. Kozlov, M. S. Nazarenko
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引用次数: 0
Abstract
We found hypomethylation of five CpG sites in the 5' region of TBX20 gene (7p14.2) in the tissues of atherosclerotic aortic plaque compared to dilated part of aorta in patients with ascending aortic aneurysm. Using GEO database, we found that the DNA methylation level in the chr7:35253926-35262250 region changes in opposite direction in aortic dissection and aortic atherosclerosis. The results suggest an alteration in epigenetic regulation both in aortic atherosclerosis and aortic aneurysm.
期刊介绍：
Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.
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