Rishyashring R. Iyer, Lingxiao Yang, Janet E. Sorrells, Eric J. Chaney, Darold R. Spillman, Stephen A. Boppart
{"title":"Dispersion mismatch correction for evident chromatic anomaly in low coherence interferometry","authors":"Rishyashring R. Iyer, Lingxiao Yang, Janet E. Sorrells, Eric J. Chaney, Darold R. Spillman, Stephen A. Boppart","doi":"10.1063/5.0207414","DOIUrl":null,"url":null,"abstract":"The applications of ultrafast optics to biomedical microscopy have expanded rapidly in recent years, including interferometric techniques like optical coherence tomography and microscopy (OCT/OCM). The advances of ultra-high resolution OCT and the inclusion of OCT/OCM in multimodal systems combined with multiphoton microscopy have marked a transition from using pseudo-continuous broadband sources, such as superluminescent diodes, to ultrafast supercontinuum optical sources. We report anomalies in the dispersion profiles of low-coherence ultrafast pulses through long and non-identical arms of a Michelson interferometer that are well beyond group delay or third-order dispersions. This chromatic anomaly worsens the observed axial resolution and causes fringe artifacts in the reconstructed tomograms in OCT/OCM using traditional algorithms. We present DISpersion COmpensation Techniques for Evident Chromatic Anomalies (DISCOTECA) as a universal solution to address the problem of chromatic dispersion mismatch in interferometry, especially with ultrafast sources. First, we demonstrate the origin of these artifacts through the self-phase modulation of ultrafast pulses due to focusing elements in the beam path. Next, we present three solution paradigms for DISCOTECA: optical, optoelectronic, and computational, along with quantitative comparisons to traditional methods to highlight the improvements to the dynamic range and axial profile. We explain the piecewise reconstruction of the phase mismatch between the arms of the spectral-domain interferometer using a modified short-term Fourier transform algorithm inspired by spectroscopic OCT. Finally, we present a decision-making guide for evaluating the utility of DISCOTECA in interferometry and for the artifact-free reconstruction of OCT images using an ultrafast supercontinuum source for biomedical applications.","PeriodicalId":8198,"journal":{"name":"APL Photonics","volume":"2 1","pages":""},"PeriodicalIF":5.4000,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"APL Photonics","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1063/5.0207414","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPTICS","Score":null,"Total":0}
引用次数: 0
Abstract
The applications of ultrafast optics to biomedical microscopy have expanded rapidly in recent years, including interferometric techniques like optical coherence tomography and microscopy (OCT/OCM). The advances of ultra-high resolution OCT and the inclusion of OCT/OCM in multimodal systems combined with multiphoton microscopy have marked a transition from using pseudo-continuous broadband sources, such as superluminescent diodes, to ultrafast supercontinuum optical sources. We report anomalies in the dispersion profiles of low-coherence ultrafast pulses through long and non-identical arms of a Michelson interferometer that are well beyond group delay or third-order dispersions. This chromatic anomaly worsens the observed axial resolution and causes fringe artifacts in the reconstructed tomograms in OCT/OCM using traditional algorithms. We present DISpersion COmpensation Techniques for Evident Chromatic Anomalies (DISCOTECA) as a universal solution to address the problem of chromatic dispersion mismatch in interferometry, especially with ultrafast sources. First, we demonstrate the origin of these artifacts through the self-phase modulation of ultrafast pulses due to focusing elements in the beam path. Next, we present three solution paradigms for DISCOTECA: optical, optoelectronic, and computational, along with quantitative comparisons to traditional methods to highlight the improvements to the dynamic range and axial profile. We explain the piecewise reconstruction of the phase mismatch between the arms of the spectral-domain interferometer using a modified short-term Fourier transform algorithm inspired by spectroscopic OCT. Finally, we present a decision-making guide for evaluating the utility of DISCOTECA in interferometry and for the artifact-free reconstruction of OCT images using an ultrafast supercontinuum source for biomedical applications.
近年来,超快光学在生物医学显微镜方面的应用迅速扩大,其中包括光学相干断层扫描和显微镜(OCT/OCM)等干涉测量技术。超高分辨率 OCT 的发展以及将 OCT/OCM 纳入与多光子显微镜相结合的多模态系统,标志着从使用伪连续宽带光源(如超发光二极管)到超快超连续光学光源的过渡。我们报告了低相干超快脉冲在通过迈克尔逊干涉仪的非相同长臂时的色散曲线异常现象,这种异常现象远远超出了群延迟或三阶色散。这种色度异常会降低观察到的轴向分辨率,并在使用传统算法的 OCT/OCM 重建断层图中造成条纹伪影。我们提出了针对明显色度异常的色散补偿技术(DISCOTECA),作为解决干涉测量(尤其是超快光源)中色散失配问题的通用解决方案。首先,我们通过光束路径中的聚焦元件引起的超快脉冲自相位调制,证明了这些伪影的起源。接下来,我们介绍了 DISCOTECA 的三种解决范例:光学、光电和计算,并与传统方法进行了定量比较,以突出动态范围和轴向剖面的改进。我们解释了光谱域干涉仪两臂之间相位失配的分片重建,使用的是受光谱 OCT 启发而改进的短期傅立叶变换算法。最后,我们提出了一个决策指南,用于评估 DISCOTECA 在干涉测量中的实用性,以及在生物医学应用中使用超快超连续光源对 OCT 图像进行无伪影重建。
APL PhotonicsPhysics and Astronomy-Atomic and Molecular Physics, and Optics
CiteScore
10.30
自引率
3.60%
发文量
107
审稿时长
19 weeks
期刊介绍:
APL Photonics is the new dedicated home for open access multidisciplinary research from and for the photonics community. The journal publishes fundamental and applied results that significantly advance the knowledge in photonics across physics, chemistry, biology and materials science.