Role of MicroRNA Modulated Wnt Pathway in Breast Cancer and Its Therapeutic Use

Pub Date : 2024-07-23 DOI:10.3103/s0095452724040108

Shrila Banerjee, Abul Kalam Azad Mandal

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Abstract

The Wnt pathway plays a key role in cell growth, survival, and self-renewal which is frequently hyperactive in various cancers. It is categorized into canonical and non-canonical Wnt pathways depending upon the influence of the β-catenin protein. Gene expressions are often altered by small non-coding RNAs, known as microRNAs (miRNAs) leading to regulation involving cell-proliferating pathways like Wnt in various cancers, including breast. miRNAs frequently act as an oncogene or a tumor-suppressor depending upon their regulatory roles. In this review article, the significance of the Wnt pathway in cancer progression, most importantly breast cancer is widely explained. The role of miRNAs in modulating varied pathways especially the Wnt pathway in breast cancer is also reviewed here. Breast cancer suppression using new-age miRNA therapeutics is showing promising results and the use of different nanocarriers for therapeutic delivery is increasing its efficacy. Targeting the Wnt pathway and its related genes can show a new path for the treatment of cancer stem cells (CSCs) of breast and other cancers as the Wnt pathway plays a pivotal role in maintaining the stemness of CSCs. Moreover, controlling the Wnt pathway through miRNA nanocarrier can give another dimension to breast cancer therapy by inhibiting aggressive and tricky breast cancer stem cells.

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微小核糖核酸调控的 Wnt 通路在乳腺癌中的作用及其治疗用途

摘要 Wnt通路在细胞生长、存活和自我更新中起着关键作用，在各种癌症中经常过度活跃。根据β-catenin蛋白的影响，Wnt通路可分为规范Wnt通路和非规范Wnt通路。在包括乳腺癌在内的各种癌症中，基因表达通常会被称为 microRNAs（miRNAs）的小型非编码 RNAs 改变，从而导致涉及 Wnt 等细胞增殖途径的调控。这篇综述文章广泛阐述了 Wnt 通路在癌症进展（尤其是乳腺癌）中的重要作用。本文还综述了 miRNA 在乳腺癌中调节各种通路（尤其是 Wnt 通路）的作用。利用新时代的 miRNA 疗法抑制乳腺癌的治疗效果很好，使用不同的纳米载体进行治疗也提高了疗效。靶向Wnt通路及其相关基因可为治疗乳腺癌和其他癌症的癌症干细胞（CSCs）开辟一条新路，因为Wnt通路在维持CSCs的干性方面发挥着关键作用。此外，通过 miRNA 纳米载体控制 Wnt 通路可以抑制具有侵袭性和棘手的乳腺癌干细胞，从而为乳腺癌治疗提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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