Utilizing Bimetallic Nanoparticle-Catalyzed Methylene Blue for Sensitive Detection of CYFRA21-1: A Biomarker for Esophageal Cancer

IF 2.8 3区化学 Q2 CHEMISTRY, APPLIED Topics in Catalysis Pub Date : 2024-07-25 DOI:10.1007/s11244-024-01990-0

Xiaomei Huang, Yuxuan Xing, Chunbin Han, Shiyao Chen, Sicong Jiang, Shankramma Kalikeri, Yang Wang

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Abstract

A highly sensitive electrochemical immunosensor for the detection of CYFRA21-1, a biomarker for esophageal cancer, was developed using bimetallic nanoparticle-catalyzed methylene blue as a signal amplification strategy. Au@Rh dendritic nanocrystals (DNCs) were employed as the sensing platform, while PtPd nanoparticles on polydopamine-modified hollow carbon spheres (PtPd/PDA/HCSs) were used as the signal probe. The immunosensor exhibited a wide linear range of 0.05 to 50 ng/mL, with a low detection limit of 0.01 ng/mL. It also demonstrated good specificity, reproducibility, and accuracy, with recoveries ranging from 96.8 to 104.5% in human serum samples. The presence of interfering substances commonly found in human serum did not significantly affect the immunosensor’s performance, with a relative error of less than 5%. The proposed immunosensor’s analytical performance surpasses other reported methods, making it a promising tool for early diagnosis and monitoring of esophageal cancer in clinical applications.

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利用双金属纳米粒子催化亚甲基蓝灵敏检测食管癌生物标记物 CYFRA21-1

利用双金属纳米粒子催化亚甲基蓝作为信号放大策略，开发了一种用于检测食管癌生物标记物 CYFRA21-1 的高灵敏度电化学免疫传感器。Au@Rh 树枝状纳米晶体（DNCs）被用作传感平台，而聚多巴胺改性空心碳球（PtPd/PDA/HCSs）上的铂钯纳米颗粒被用作信号探针。该免疫传感器的线性范围为 0.05 至 50 ng/mL，检测限低至 0.01 ng/mL。它还表现出良好的特异性、再现性和准确性，在人体血清样本中的回收率为 96.8% 至 104.5%。人血清中常见的干扰物质对免疫传感器的性能影响不大，相对误差小于 5%。所提出的免疫传感器的分析性能超过了其他已报道的方法，因此有望成为临床应用中早期诊断和监测食管癌的工具。

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来源期刊

Topics in Catalysis 化学-物理化学

CiteScore

5.70

自引率

5.60%

发文量

197

审稿时长

2 months

期刊介绍： Topics in Catalysis publishes topical collections in all fields of catalysis which are composed only of invited articles from leading authors. The journal documents today’s emerging and critical trends in all branches of catalysis. Each themed issue is organized by renowned Guest Editors in collaboration with the Editors-in-Chief. Proposals for new topics are welcome and should be submitted directly to the Editors-in-Chief. The publication of individual uninvited original research articles can be sent to our sister journal Catalysis Letters. This journal aims for rapid publication of high-impact original research articles in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis.