{"title":"Synergistic convergence of materials and enzymes for biosensing and self-sustaining energy devices towards on-body health monitoring","authors":"Suntisak Khumngern, Itthipon Jeerapan","doi":"10.1038/s43246-024-00557-6","DOIUrl":null,"url":null,"abstract":"Wearable enzyme-based biosensors enable advanced healthcare diagnostics through the monitoring of biomarkers and physiological states. The integration of materials engineering and enzyme conjugation has established the groundwork for advancements in modern analytical chemistry, poised to extend the frontiers of wearable biosensing further. Recent advancements in enzymatic biofuel cells have also enhanced devices by harnessing biofuels, such as glucose and lactate in biofluids. Importantly, biofuel cells offer the potential for self-powered biosensors. Here, we present an overview of the principles and considerations associated with engineering materials and integrating enzymes with electrodes to achieve effective wearable biosensing and self-sustaining biofuel cell-based energy systems. Furthermore, we discuss challenges encountered by enzymatic sensors and biofuel cells. Representative applications of wearable devices in healthcare settings are highlighted, along with a summary of real sample analyses, emphasizing the concentration ranges of analytes present in actual sweat samples to underscore their relevance in real-world scenarios. Finally, the discussion explores the anticipated impact of future material innovations and integrations on the development of next-generation wearable biodevices. Enzyme-based wearable biosensors offer a unique approach for biomarker detection. This Review discusses recent progress in enzymatic biosensors and biofuel cells, where biofuels self-power the device while enzymes concurrently work for biomarker detection.","PeriodicalId":10589,"journal":{"name":"Communications Materials","volume":null,"pages":null},"PeriodicalIF":7.5000,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43246-024-00557-6.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Communications Materials","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43246-024-00557-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Wearable enzyme-based biosensors enable advanced healthcare diagnostics through the monitoring of biomarkers and physiological states. The integration of materials engineering and enzyme conjugation has established the groundwork for advancements in modern analytical chemistry, poised to extend the frontiers of wearable biosensing further. Recent advancements in enzymatic biofuel cells have also enhanced devices by harnessing biofuels, such as glucose and lactate in biofluids. Importantly, biofuel cells offer the potential for self-powered biosensors. Here, we present an overview of the principles and considerations associated with engineering materials and integrating enzymes with electrodes to achieve effective wearable biosensing and self-sustaining biofuel cell-based energy systems. Furthermore, we discuss challenges encountered by enzymatic sensors and biofuel cells. Representative applications of wearable devices in healthcare settings are highlighted, along with a summary of real sample analyses, emphasizing the concentration ranges of analytes present in actual sweat samples to underscore their relevance in real-world scenarios. Finally, the discussion explores the anticipated impact of future material innovations and integrations on the development of next-generation wearable biodevices. Enzyme-based wearable biosensors offer a unique approach for biomarker detection. This Review discusses recent progress in enzymatic biosensors and biofuel cells, where biofuels self-power the device while enzymes concurrently work for biomarker detection.
期刊介绍:
Communications Materials, a selective open access journal within Nature Portfolio, is dedicated to publishing top-tier research, reviews, and commentary across all facets of materials science. The journal showcases significant advancements in specialized research areas, encompassing both fundamental and applied studies. Serving as an open access option for materials sciences, Communications Materials applies less stringent criteria for impact and significance compared to Nature-branded journals, including Nature Communications.