Iodide clusters of molybdenum and tungsten as promising agents for photodynamic inactivation and therapy

IF 1.7 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Russian Chemical Bulletin Pub Date : 2024-07-26 DOI:10.1007/s11172-024-4272-0
M. A. Mikhailov, M. N. Sokolov
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Abstract

Octahedral iodide clusters of molybdenum and tungsten [M6I8L6] are considered as promising components of new classes of luminescent materials. When excited with the light at a wavelength of ≤450 nm, the clusters form long-lived triplet states emitting red phosphorescence. This phosphorescence is deactivated in the presence of molecular oxygen to form singlet oxygen in a high yield. Due to the capability of photogenerating singlet oxygen, the [M6I8L6] clusters and related materials exhibit photoinduced cytotoxicity and bactericidal action. Universal methods developed to date make it possible to prepare cluster compounds with specified compositions and properties depending on ligand L. This review considers the prospects for developing drugs for antimicrobial photodynamic inactivation and photodynamic cancer therapy based on the [M6I8L6] clusters.

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钼和钨的碘化物团簇是光动力灭活和治疗的理想药剂
钼和钨的八面体碘化物团簇[M6I8L6]被认为是新型发光材料中很有前途的成分。当被波长≤450 nm 的光激发时,这些团簇会形成长寿命的三重态,发出红色磷光。这种磷光在分子氧的存在下会失活,形成高产率的单线态氧。由于具有光生单线态氧的能力,[M6I8L6] 团簇和相关材料表现出光诱导的细胞毒性和杀菌作用。本综述探讨了基于[M6I8L6]团簇开发抗菌光动力灭活药物和光动力癌症治疗药物的前景。
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来源期刊
Russian Chemical Bulletin
Russian Chemical Bulletin 化学-化学综合
CiteScore
2.70
自引率
47.10%
发文量
257
审稿时长
3-8 weeks
期刊介绍: Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.
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