Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4343-2
A. P. Krinochkin, D. S. Kopchuk, M. I. Valieva, E. S. Starnovskaya, Ya. K. Shtaitz, G. A. Kim, N. V. Slovesnova, A. S. Minin, A. V. Belousova, V. A. Pozdina, I. S. Kovalev, G. V. Zyryanov, A. N. Tsmokalyuk, I. L. Nikonov, V. L. Rusinov
New 5-[4(3)-R-phenyl]-2,2′-bipyridines bearing the 1,1,7,7-tetrakis(tert-butoxycarbonylmethyl)-1,4,7-triazaheptane (DTTA) moiety at the C(6) position (R = Cl, Br, CF3) and their water-soluble EuIII complexes were synthesized. The photophysical properties of the synthesized complexes were investigated. More efficient sensitization of Eu3+ cation luminescence was demonstrated for a number of halogen-containing ligands. Some chelates exhibited moderate cell-staining ability. The synthesized compounds did not show significant photodynamic activity, which may be due to the inhibition of the in situ generation of reactive oxygen species via the supposed interaction with the methylene moiety of DTTA-appended 2,2′-bipyridine ligands.
{"title":"New europium complexes of C(6)-DTTA-appended 5-aryl-2,2′-bipyridines: synthesis, luminescence, and evaluation of their activity against cell culture","authors":"A. P. Krinochkin, D. S. Kopchuk, M. I. Valieva, E. S. Starnovskaya, Ya. K. Shtaitz, G. A. Kim, N. V. Slovesnova, A. S. Minin, A. V. Belousova, V. A. Pozdina, I. S. Kovalev, G. V. Zyryanov, A. N. Tsmokalyuk, I. L. Nikonov, V. L. Rusinov","doi":"10.1007/s11172-024-4343-2","DOIUrl":"https://doi.org/10.1007/s11172-024-4343-2","url":null,"abstract":"<p>New 5-[4(3)-R-phenyl]-2,2′-bipyridines bearing the 1,1,7,7-tetrakis(<i>tert</i>-butoxycarbonylmethyl)-1,4,7-triazaheptane (DTTA) moiety at the C(6) position (R = Cl, Br, CF<sub>3</sub>) and their water-soluble Eu<sup>III</sup> complexes were synthesized. The photophysical properties of the synthesized complexes were investigated. More efficient sensitization of Eu<sup>3+</sup> cation luminescence was demonstrated for a number of halogen-containing ligands. Some chelates exhibited moderate cell-staining ability. The synthesized compounds did not show significant photodynamic activity, which may be due to the inhibition of the <i>in situ</i> generation of reactive oxygen species <i>via</i> the supposed interaction with the methylene moiety of DTTA-appended 2,2′-bipyridine ligands.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4338-z
E. V. Ivanova, E. A. Lebedeva, D. K. Trukhinov, A. V. Lebedev, M. Balasoiu, S. A. Astaf’eva
A simple and affordable in situ synthesis of a carbon fiber@magnetite hybrid for use as a filler in shielding polymer materials is proposed. The presence of magnetic particles on the carbon fiber was confirmed by X-ray diffraction, and the effect of modification on the structural properties of the components and the magnetic properties of the system was analyzed. The analysis of the structural characteristics and the magnetic properties of the components obtained during the synthesis process was carried out. The modification of the surface of the carbon fiber with magnetite made it possible to obtain for the resulting hybrid a magnetic moment value that is three times higher than that of a mechanical mixture of carbon fiber and magnetite with the same composition.
本文提出了一种简单、经济的原位合成碳纤维@磁铁矿混合物的方法,该混合物可用作屏蔽聚合物材料的填充物。通过 X 射线衍射证实了碳纤维上磁性颗粒的存在,并分析了改性对组分结构特性和系统磁性能的影响。对合成过程中获得的成分的结构特征和磁性能进行了分析。用磁铁矿对碳纤维表面进行改性后,得到的混合体的磁矩值比相同成分的碳纤维和磁铁矿机械混合物的磁矩值高出三倍。
{"title":"In situ synthesis of magnetite on carbon fiber surface","authors":"E. V. Ivanova, E. A. Lebedeva, D. K. Trukhinov, A. V. Lebedev, M. Balasoiu, S. A. Astaf’eva","doi":"10.1007/s11172-024-4338-z","DOIUrl":"https://doi.org/10.1007/s11172-024-4338-z","url":null,"abstract":"<p>A simple and affordable <i>in situ</i> synthesis of a carbon fiber@magnetite hybrid for use as a filler in shielding polymer materials is proposed. The presence of magnetic particles on the carbon fiber was confirmed by X-ray diffraction, and the effect of modification on the structural properties of the components and the magnetic properties of the system was analyzed. The analysis of the structural characteristics and the magnetic properties of the components obtained during the synthesis process was carried out. The modification of the surface of the carbon fiber with magnetite made it possible to obtain for the resulting hybrid a magnetic moment value that is three times higher than that of a mechanical mixture of carbon fiber and magnetite with the same composition.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4344-1
V. P. Stefanets, N. A. Sanina, G. V. Shilov, A. I. Dmitriev, M. V. Zhidkov, S. M. Aldoshin
Two complex dysprosium(iii) salts of composition Na[Dy(hfac)4] (1) and Q[Dy(hfac)4]2(2), where hfac is the hexafluoroacetylacetonate anion and Q is 1,1′-dimethyl-4,4′-bipyridinium, were synthesized and studied by X-ray diffraction. An analysis of the X-ray diffraction data using the Shape program revealed noticeable distortions of two [DyO8] coordination polyhedra of salt 2 anions; the Dy atoms are nonequivalent and have a biaugmented trigonal prismatic (C2v) and triangular dodecahedral (D2d) geometry. The experimental studies and the analysis of the magnetic properties of 2 showed that this compound exhibits a field-induced slow relaxation of magnetization, which is described by the Orbach mechanism (Ueff = 23.0 K, τ0 = 2.68 · 10−8 s).
{"title":"Salt of dysprosium(iii) tetrakis(hexafluoroacetylacetonate) with 1,1′-dimethyl-4,4′-bipyridinium as a new single-ion magnet","authors":"V. P. Stefanets, N. A. Sanina, G. V. Shilov, A. I. Dmitriev, M. V. Zhidkov, S. M. Aldoshin","doi":"10.1007/s11172-024-4344-1","DOIUrl":"https://doi.org/10.1007/s11172-024-4344-1","url":null,"abstract":"<p>Two complex dysprosium(<span>iii</span>) salts of composition Na[Dy(hfac)<sub>4</sub>] <b>(1)</b> and Q[Dy(hfac)<sub>4</sub>]<sub>2</sub> <b>(2)</b>, where hfac is the hexafluoroacetylacetonate anion and Q is 1,1′-dimethyl-4,4′-bipyridinium, were synthesized and studied by X-ray diffraction. An analysis of the X-ray diffraction data using the Shape program revealed noticeable distortions of two [DyO<sub>8</sub>] coordination polyhedra of salt <b>2</b> anions; the Dy atoms are nonequivalent and have a biaugmented trigonal prismatic (<i>C</i><sub>2v</sub>) and triangular dodecahedral (<i>D</i><sub>2d</sub>) geometry. The experimental studies and the analysis of the magnetic properties of <b>2</b> showed that this compound exhibits a field-induced slow relaxation of magnetization, which is described by the Orbach mechanism (<i>U</i><sub>eff</sub> = 23.0 K, τ<sub>0</sub> = 2.68 · 10<sup>−8</sup> s).</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4349-9
Z. S. Kinzyabaeva
The ultrasonic induced oxidative addition reaction of C60 fullerene to tris(hydroxymethyl)-aminomethane in a toluene—DMF solvent mixture in the presence of LiOH and Pb(OAc)4 at room temperature in an aerobic environment gave 47% yield of the C60 fullerene monoadduct containing in its structure a morpholine fragment annulated to the [60]fullerene core.
{"title":"Synthesis of 3′,3′-bis(hydroxymethyl)morpholino[5′,6′:1,9](C60-Ih)[5,6]fullerene by the oxidative addition reaction of tris(hydroxymethyl)aminomethane to C60 fullerene under the action of ultrasonic radiation","authors":"Z. S. Kinzyabaeva","doi":"10.1007/s11172-024-4349-9","DOIUrl":"https://doi.org/10.1007/s11172-024-4349-9","url":null,"abstract":"<p>The ultrasonic induced oxidative addition reaction of C<sub>60</sub> fullerene to tris(hydroxymethyl)-aminomethane in a toluene—DMF solvent mixture in the presence of LiOH and Pb(OAc)<sub>4</sub> at room temperature in an aerobic environment gave 47% yield of the C<sub>60</sub> fullerene monoadduct containing in its structure a morpholine fragment annulated to the [60]fullerene core.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4358-8
Yu. N. Bubnov, A. A. Prishchenko, M. V. Livantsov, O. P. Novikova, L. I. Livantsova, S. V. Baranin
Convenient synthesis of phosphorus-containing derivatives of succinic acid, which contain functionalized phosphonous, phosphonic, and phosphinic acid moieties have been developed. The nucleophilic addition of bis(trimethylsiloxy)phosphine to diesters of maleic, itaconic, and acetylenedicarboxylic acids proceeds regioselectively to give a number of functionalized phosphonites. Further aminomethylation of these compounds affords various target acid derivatives. The resulting compounds are of interest as promising biologically active substances and water-soluble ligands.
{"title":"Synthesis of functionalized organophosphorus derivatives of succinic acid","authors":"Yu. N. Bubnov, A. A. Prishchenko, M. V. Livantsov, O. P. Novikova, L. I. Livantsova, S. V. Baranin","doi":"10.1007/s11172-024-4358-8","DOIUrl":"https://doi.org/10.1007/s11172-024-4358-8","url":null,"abstract":"<p>Convenient synthesis of phosphorus-containing derivatives of succinic acid, which contain functionalized phosphonous, phosphonic, and phosphinic acid moieties have been developed. The nucleophilic addition of bis(trimethylsiloxy)phosphine to diesters of maleic, itaconic, and acetylenedicarboxylic acids proceeds regioselectively to give a number of functionalized phosphonites. Further aminomethylation of these compounds affords various target acid derivatives. The resulting compounds are of interest as promising biologically active substances and water-soluble ligands.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4363-y
A. V. Petrova, V. S. Pokrovsky, E. F. Khusnutdinova, G. Babayeva, A. A. Kondurakiy, A. A. Chernysheva, A. E. Barmashov, O. B. Kazakova
New oleanonic acid derivatives bearing the pyridine moieties at the positions C(2) and C(28) were synthesized. Heterocyclic moieties were introduced in position C(2) of oleanonic acid by aldol condensation, and in position C(28) by N-acylation. Cytotoxicity of the synthesized compounds was evaluated against 12 tumor cell lines. Aminopyridine-derived oleanonic acid amides with 3- and 4-pyridinylmethylidene group were found to be active against a human prostate cancer cell line PC3 with half maximal inhibitory concentration (IC50) values equal to 1.20 and 2.06 µmol L−1, respectively.
{"title":"Synthesis and cytotoxicity of new oleanonic acid derivatives bearing pyridine substituent at positions C(2) and C(28)","authors":"A. V. Petrova, V. S. Pokrovsky, E. F. Khusnutdinova, G. Babayeva, A. A. Kondurakiy, A. A. Chernysheva, A. E. Barmashov, O. B. Kazakova","doi":"10.1007/s11172-024-4363-y","DOIUrl":"https://doi.org/10.1007/s11172-024-4363-y","url":null,"abstract":"<p>New oleanonic acid derivatives bearing the pyridine moieties at the positions C(2) and C(28) were synthesized. Heterocyclic moieties were introduced in position C(2) of oleanonic acid by aldol condensation, and in position C(28) by N-acylation. Cytotoxicity of the synthesized compounds was evaluated against 12 tumor cell lines. Aminopyridine-derived oleanonic acid amides with 3- and 4-pyridinylmethylidene group were found to be active against a human prostate cancer cell line PC3 with half maximal inhibitory concentration (IC<sub>50</sub>) values equal to 1.20 and 2.06 µmol L<sup>−1</sup>, respectively.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4356-x
K. V. Belyaeva, L. P. Nikitina, A. V. Afonin, B. A. Trofimov
A three-components regioselective synthesis of 3-[2-formamidovinyl(phenyl)amino]-acrylic acid based on an opening of the imidazole ring under the influence of acetylene carboxylic acids esters or cyanophenylacetylene in aqueous acetonitrile in up to 86% yields has been developed.
{"title":"Hydrolytic opening of the imidazole ring under action of acetylenecarboxylic acid derivatives","authors":"K. V. Belyaeva, L. P. Nikitina, A. V. Afonin, B. A. Trofimov","doi":"10.1007/s11172-024-4356-x","DOIUrl":"https://doi.org/10.1007/s11172-024-4356-x","url":null,"abstract":"<p>A three-components regioselective synthesis of 3-[2-formamidovinyl(phenyl)amino]-acrylic acid based on an opening of the imidazole ring under the influence of acetylene carboxylic acids esters or cyanophenylacetylene in aqueous acetonitrile in up to 86% yields has been developed.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4359-7
A. S. Agarkov, D. O. Mingazhetdinova, A. A. Nefedova, E. R. Gabitova, A. S. Ovsyannikov, I. A. Litvinov, D. R. Islamov, P. V. Dorovatovskii, S. E. Solovieva, I. S. Antipin
New 2-(4-carboxyphenylhydrazinylidene)[1,3]thiazolo[3,2-a]pyrimidine derivatives were synthesized in high yields by the reactions of 5-aryl-6-ethoxycarbonyl-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine with 4-carboxyphenyldiazonium chloride. The azo coupling occurs at the 2 position of the substrate. Different types of intra- and intermolecular non-covalent interactions can affect the supramolecular assembly of the molecules in the crystal structures and the molecular configuration of the synthesized compounds. The combined contribution of supramolecular non-covalent interactions leads to several types of the self-assembly in the crystalline phase, such as hydrogen-, chalcogen-, and π—π-bonded racemic dimers. In the case of compounds containing the m-chlorophenyl substituent at the C(5) position of the thiazolo[3,2-a]-pyrimidine scaffold, these interactions lead to the formation of halogen-bonded homochiral chains. Due to the π—π stacking between the electron-rich thiazolopyrimidine scaffold and the electron-deficient carboxyphenyl moiety, there occurs the formation of dense layers in the solid phase when selecting the appropriate substituents at the C(5) atom. The crystallization conditions (vapor diffusion and slow evaporation) were found to influence the configuration of the C=N-arylhydrazone moiety.
{"title":"Structure-forming non-covalent bonding of new 2-(4-carboxyphenylhydrazinylidene)[1,3]thiazolo[3,2-a]pyrimidines in the crystalline phase","authors":"A. S. Agarkov, D. O. Mingazhetdinova, A. A. Nefedova, E. R. Gabitova, A. S. Ovsyannikov, I. A. Litvinov, D. R. Islamov, P. V. Dorovatovskii, S. E. Solovieva, I. S. Antipin","doi":"10.1007/s11172-024-4359-7","DOIUrl":"https://doi.org/10.1007/s11172-024-4359-7","url":null,"abstract":"<p>New 2-(4-carboxyphenylhydrazinylidene)[1,3]thiazolo[3,2-<i>a</i>]pyrimidine derivatives were synthesized in high yields by the reactions of 5-aryl-6-ethoxycarbonyl-7-methyl-3-oxo-2,3-dihydro-5<i>H</i>-[1,3]thiazolo[3,2-<i>a</i>]pyrimidine with 4-carboxyphenyldiazonium chloride. The azo coupling occurs at the 2 position of the substrate. Different types of intra- and intermolecular non-covalent interactions can affect the supramolecular assembly of the molecules in the crystal structures and the molecular configuration of the synthesized compounds. The combined contribution of supramolecular non-covalent interactions leads to several types of the self-assembly in the crystalline phase, such as hydrogen-, chalcogen-, and π—π-bonded racemic dimers. In the case of compounds containing the <i>m</i>-chlorophenyl substituent at the C(5) position of the thiazolo[3,2-<i>a</i>]-pyrimidine scaffold, these interactions lead to the formation of halogen-bonded homochiral chains. Due to the π—π stacking between the electron-rich thiazolopyrimidine scaffold and the electron-deficient carboxyphenyl moiety, there occurs the formation of dense layers in the solid phase when selecting the appropriate substituents at the C(5) atom. The crystallization conditions (vapor diffusion and slow evaporation) were found to influence the configuration of the C=N-arylhydrazone moiety.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4354-z
E. V. Salimova, L. V. Parfenova
In continuation of our studies on modification of fusidane triterpenoids, the alkynyl moieties were introduced into fusidic acid to synthesize new compounds promising as antimicrobial and antitumor agents. Transformations of the triple bond via the CuI-catalyzed reactions afforded new 1,2,3-triazoles as well as mono- and diacetylenic derivatives.
在继续研究改性夫西地三萜类化合物的过程中,我们将炔基引入夫西地酸,合成了有望用作抗菌剂和抗肿瘤剂的新化合物。通过 CuI 催化的三键转化反应,获得了新的 1,2,3-三唑以及单乙酰基和双乙酰基衍生物。
{"title":"Synthesis of acetylenic and 1,2,3-triazolyl analogs of fusidic acid","authors":"E. V. Salimova, L. V. Parfenova","doi":"10.1007/s11172-024-4354-z","DOIUrl":"https://doi.org/10.1007/s11172-024-4354-z","url":null,"abstract":"<p>In continuation of our studies on modification of fusidane triterpenoids, the alkynyl moieties were introduced into fusidic acid to synthesize new compounds promising as antimicrobial and antitumor agents. Transformations of the triple bond <i>via</i> the Cu<sup>I</sup>-catalyzed reactions afforded new 1,2,3-triazoles as well as mono- and diacetylenic derivatives.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1007/s11172-024-4352-1
E. A. Kudryashova, M. I. Valieva, N. V. Slovesnova, A. V. Bolotova, Yu. M. Sayfutdinova, S. E. Vatolina, I. L. Nikonov, K. V. Grzhegorzhevskii, D. S. Kopchuk, G. V. Zyryanov, V. L. Rusinov
New (bi)pyridine derivatives of the antimicrobial drug ornidazole were synthesized by alkylation of pyridyl- and 2,2′-bipyridyl-phenolic derivatives for the first time. The proposed methodology makes it possible to expand the range of ornidazole derivatives with increased antibacterial activity.
{"title":"Synthesis of (bi)pyridine derivatives of ornidazole","authors":"E. A. Kudryashova, M. I. Valieva, N. V. Slovesnova, A. V. Bolotova, Yu. M. Sayfutdinova, S. E. Vatolina, I. L. Nikonov, K. V. Grzhegorzhevskii, D. S. Kopchuk, G. V. Zyryanov, V. L. Rusinov","doi":"10.1007/s11172-024-4352-1","DOIUrl":"https://doi.org/10.1007/s11172-024-4352-1","url":null,"abstract":"<p>New (bi)pyridine derivatives of the antimicrobial drug ornidazole were synthesized by alkylation of pyridyl- and 2,2′-bipyridyl-phenolic derivatives for the first time. The proposed methodology makes it possible to expand the range of ornidazole derivatives with increased antibacterial activity.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}