E. M. Mukhin, K. V. Savateev, P. A. Slepukhin, V. L. Rusinov
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引用次数: 0
Abstract
The possibility of generating a carbanion using the reaction of 3-bromo-5,7-dimethylpyrazolo[1,5-a]pyrimidine with BunLi followed by the electrophilic addition was investigated. The obtained results provide evidence for the presence of several reaction centers in the substrate, resulting in the formation of unexpected reaction products. These results offer new prospects for the functionalization of pyrazolo[1,5-a]pyrimidines and allow the preparation of new pharmacologically active derivatives of this series. The structures and purity of all the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy, mass spectrometry, elemental analysis, and X-ray crystallography.
期刊介绍:
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.