3,6-Disubstituted derivatives of 1,2,4,5-tetrazine with pyridinyl amidine moieties and condensed systems on their basis: synthesis, docking, and antibacterial activity
R. I. Ishmetova, N. K. Ignatenko, N. A. Gerasimova, D. V. Belyaev, I. I. Butorin, O. A. Konovalova, E. E. Khramtsova, D. V. Dianov, N. P. Evstigneeva, D. V. Vakhrusheva, S. Yu. Krasnoborova, N. V. Zilberberg, N. V. Kungurov, G. L. Rusinov, V. N. Charushin
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引用次数: 0
Abstract
New 3,6-disubstituted 1,2,4,5-tetrazine derivatives with pyridyl-substituted amidine moieties, as well as [1,2,4]triazolo[1,5-b][1,2,4,5-tetrazines and bis[1,2,4]triazolo-[1,5-b:1,5-f][1,2,4,5]tetrazines on their basis were synthesized. The obtained compounds were screened for activity against Neisseria gonorrhoeae and Mycobacterium tuberculosis. Compounds with pronounced antibacterial activity were detected. Docking was performed to determine a possible antibacterial effect of the compounds.
期刊介绍：
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.
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