Biodegradable Magnetic Vesicles for Magnetic Hyperthermia Stimulated Drug Release

Abstract

Magnetic nanomaterials have emerged as an effective drug-delivery platform for targeted imaging and therapy. However, it remains challenging to fabricate biodegradable magnetic nanoparticles with controllable drug release behaviors and strong magnetic responsiveness. Here an asiaticoside-loaded biodegradable magnetic vesicle is developed based on the self-assembly of amphiphilic block copolymer tethered superparamagnetic iron oxide nanoparticles. Thanks to the collective properties, the magnetic vesicles show stronger magnetic responsiveness than individual nanoparticles. Additionally, the magnetic vesicles are dissociated within weeks owing to the biodegradable polymer backbone, which can significantly improve the long-term biocompatibility of the nanomaterials. The asiaticoside-loaded magnetic vesicles can readily release the payloads in an alternating magnetic field, likely due to the rising local temperature over the phase transition temperature of the polymers attached on nanoparticles. This work provides new insights into the design and construction of biodegradable magnetic nanomedicines for targeted drug delivery.