Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2024-07-29 DOI:10.1007/s10856-024-06808-9
Zahra Barabadi, Asrin Bahmani, Marzieh Jalalimonfared, Milad Ashrafizadeh, Morteza Rashtbar, Esmaeel Sharifi, Haili Tian
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Abstract

Electroconductive polymers are the materials of interest for the fabrication of electro-conductive tissues. Metal ions through the redox systems offer polymers with electrical conductivity. In this study, we processed a gelatin methacrylate (GelMA) network with gold nanoparticles (GNPs) through a redox system with parahydroxybenzaldehyde (PHB) or curcumin to enhance its electrical conductivity. Induction of the redox system with both PHB and curcumin into the GelMA, introduced some new functional groups into the polymeric network, as it has been confirmed by H-NMR and FTIR. These new bonds resulted in higher electro-conductivity when GNPs were added to the polymer. Higher electroactivity was achieved by PHB compared to the curcumin-induced redox system, and the addition of GNPs without redox system induction showed the lowest electroactivity. MTT was used to evaluate the biocompatibility of the resultant polymers, and the PHB-treated hydrogels showed higher proliferative effects on the cells. The findings of this study suggest that the introduction of a redox system by PHB in the GelMA network along with GNPs can contribute to the electrochemical properties of the material. This electroactivity can be advantageous for tissue engineering of electro-conductive tissues like cardiac and nervous tissues.

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设计并表征加入对羟基苯甲醛和姜黄素的金纳米颗粒的电活性甲基丙烯酸明胶水凝胶,用于先进的组织工程应用。
导电聚合物是制造导电组织的理想材料。金属离子通过氧化还原系统使聚合物具有导电性。在本研究中,我们通过对羟基苯甲醛(PHB)或姜黄素的氧化还原体系处理了含有金纳米粒子(GNPs)的甲基丙烯酸明胶(GelMA)网络,以增强其导电性。经 H-NMR 和 FTIR 证实,在 GelMA 中同时加入 PHB 和姜黄素的氧化还原体系会在聚合物网络中引入一些新的官能团。在聚合物中添加 GNP 时,这些新键可产生更高的电导率。与姜黄素诱导的氧化还原体系相比,PHB 具有更高的电导率,而添加 GNPs 但不诱导氧化还原体系的电导率最低。用 MTT 评估了所得聚合物的生物相容性,PHB 处理过的水凝胶对细胞的增殖效果较高。本研究的结果表明,PHB 与 GNP 一起在 GelMA 网络中引入氧化还原系统,有助于提高材料的电化学特性。这种电活性有利于心脏和神经组织等导电组织的组织工程。
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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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