Energy Metabolism Dysregulation in Myocardial Infarction: An Integrative Analysis of Ischemic Cardiomyopathy.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-07-26 DOI:10.2174/0115701611289159240724114844

Zongtao Wang, Zhixin Xie, Tudi Li, Rong Chen, Zhihuan Zeng, Jun Guo

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Abstract

Background: Myocardial metabolism is closely related to functional changes after myocardial infarction (MI).

Objective: This study aimed to present an integrative examination of human ischemic cardiomyopathy.

Methods: We used both GSE121893 single-cell suspension sequencing and GSE19303 transcription microarray data sets from the GEO database, along with a murine MI model for full-spectrum metabolite detection. Through a systematic investigation that involved differential metabolite identification and functional enrichment analysis, we shed light on the pivotal role of energy metabolism dysregulation in the progression of MI.

Results: Our findings revealed an association between the core regulatory genes CDKN1A, FOS, ITGB4, and MAP2K1 and the underlying pathophysiology of the disease. These genes are identified as critical elements in the complex landscape of myocardial ischemic disorder, highlighting novel insights into therapeutic targets and the intricate biological mechanisms involved.

Conclusion: This analysis provides a framework for future research on the metabolic alterations associated with MI.

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心肌梗死中的能量代谢失调：缺血性心肌病的综合分析》。

背景：心肌代谢与心肌梗死（MI）后的功能变化密切相关：心肌代谢与心肌梗死（MI）后的功能变化密切相关：本研究旨在对人类缺血性心肌病进行综合研究：我们利用 GEO 数据库中的 GSE121893 单细胞悬浮测序数据集和 GSE19303 转录芯片数据集以及小鼠心肌梗死模型进行全谱代谢物检测。通过差异代谢物鉴定和功能富集分析等系统研究，我们揭示了能量代谢失调在 MI 进展过程中的关键作用：我们的研究结果表明，核心调控基因 CDKN1A、FOS、ITGB4 和 MAP2K1 与该疾病的潜在病理生理学之间存在关联。这些基因被确定为心肌缺血性疾病复杂病因中的关键因素，凸显了对治疗靶点和相关复杂生物机制的新见解：这项分析为今后研究与心肌缺血相关的代谢改变提供了一个框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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