Evaluation of diagnostic potential of maternal serum ischemia modified albumin in cases of pre-eclampsia.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-30 DOI:10.1515/hmbci-2024-0010

Akshat Gupta, Puja K Jha, Richa Aggarwal, Ashok K Ahirwar, Edelbert A Almeida, Rajarshi Kar

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Abstract

Objectives: The underlying causes and mechanisms of pre-eclampsia (PE), its exact etiology remains unclear and poorly understood. Hypoxia, ischemia, and oxidative stress induced by free radicals have been associated with development of PE. Ischemia-modified albumin (IMA) is a chemically modified albumin due to oxidative stress. IMA, a serum biomarker of hypoxia, ischemia, and oxidative free radicals is a potential biomarker for PE. The aim of the current proposal was to study serum IMA as a diagnostic biomarker of pre-eclampsia (PE) in pregnant females and to evaluate the correlation between serum IMA and different markers of pre-eclampsia (BP, urinary protein, LFT, KFT, serum total protein & uric acid).

Methods: A total of 60 pregnant women aged between 21 and 35 years were recruited (30 PE cases and 30 normal pregnancy). Serum IMA was measured by spectrophotometric method developed by Bar-Or D. BP and biochemical parameters (urinary protein, LFT, KFT, serum total protein & uric acid) were also assayed and compared between two groups. Correlation analysis was done for analyzing the relationship between serum IMA and biochemical parameters.

Results: The mean serum IMA was significantly higher in normotensive pregnant females (0.93 ABSU) than PE cases (0.71 ABSU). Kidney function and liver function parameters were more deranged in PE cases than in controls. Serum IMA was positively correlated with serum creatinine (r=0.322), serum uric acid (r=0.54) and urinary protein (0.376) whereas negatively correlated with total serum bilirubin (r=-0.515) and serum albumin (r=-0.380).

Conclusions: Elevated serum IMA concentrations in normotensive pregnant controls as compared to PE cases suggest that apart from ongoing ischemia and oxidative stress in placenta IMA values are influenced by many other mechanisms in pregnancy.

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评估先兆子痫病例中母体血清缺血修饰白蛋白的诊断潜力。

目的：子痫前期（PE）的根本原因和机制及其确切病因仍不清楚，人们对其了解甚少。缺氧、缺血和自由基诱导的氧化应激与子痫前期的发生有关。缺血修饰白蛋白（IMA）是一种因氧化应激而发生化学修饰的白蛋白。IMA 是缺氧、缺血和氧化自由基的血清生物标志物，是 PE 的潜在生物标志物。本研究旨在研究血清 IMA 作为孕妇子痫前期（PE）诊断生物标志物的作用，并评估血清 IMA 与子痫前期不同标志物（血压、尿蛋白、LFT、KFT、血清总蛋白和尿酸）之间的相关性：方法：共招募了 60 名年龄在 21 至 35 岁之间的孕妇（30 名子痫前期孕妇和 30 名正常孕妇）。血压和生化指标（尿蛋白、LFT、KFT、血清总蛋白和尿酸）也进行了测定，并在两组之间进行比较。对血清 IMA 和生化指标之间的关系进行了相关分析：结果：血压正常孕妇的平均血清 IMA（0.93 ABSU）明显高于 PE 患者（0.71 ABSU）。与对照组相比，PE 患者的肾功能和肝功能指标更为失常。血清 IMA 与血清肌酐（r=0.322）、血清尿酸（r=0.54）和尿蛋白（0.376）呈正相关，而与血清总胆红素（r=-0.515）和血清白蛋白（r=-0.380）呈负相关：与 PE 病例相比，血压正常的对照组孕妇的血清 IMA 浓度升高，这表明除了胎盘持续缺血和氧化应激外，IMA 值还受到妊娠期许多其他机制的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.