Prospecting for para-endogenous anxiolytics in the human microbiome: Some promising pathways

IF 3.3 3区 心理学 Q1 BEHAVIORAL SCIENCES Pharmacology Biochemistry and Behavior Pub Date : 2024-07-26 DOI:10.1016/j.pbb.2024.173842
Stephen Skolnick
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Abstract

The gut microbiome is a vast, variable, and largely unexplored component of human biology that sits at the intersection of heritable and environmental factors, and represents a rich source of novel chemistry that is already known to be compatible with the human body. This alone would make it a promising place to search for new therapeutics, but recent work has also identified gut microbiome abnormalities in patients with a number of psychiatric disorders, including anxiety disorders—suggesting that not only treatments, but cures may lie therein. Here, we'll discuss two known “para-endogenous” anxiolytics—γ-hydroxybutyrate and the neurosteroid allopregnanolone—which have recently been discovered to be produced by the microbiome.

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在人类微生物组中寻找副内源性抗焦虑药:一些有前景的途径
肠道微生物组是人类生物学中一个庞大、多变且基本未被探索的组成部分,它位于遗传因素和环境因素的交汇处,是已知与人体相容的新型化学物质的丰富来源。仅这一点就足以让它成为寻找新疗法的理想场所,但最近的研究还发现,包括焦虑症在内的一些精神疾病患者的肠道微生物组存在异常,这表明其中不仅存在治疗方法,还可能存在治愈方法。在这里,我们将讨论两种已知的 "副内源性 "抗焦虑药--γ-羟丁酸和神经类固醇异丙孕酮--它们最近被发现是由微生物组产生的。
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来源期刊
CiteScore
6.40
自引率
2.80%
发文量
122
审稿时长
38 days
期刊介绍: Pharmacology Biochemistry & Behavior publishes original reports in the areas of pharmacology and biochemistry in which the primary emphasis and theoretical context are behavioral. Contributions may involve clinical, preclinical, or basic research. Purely biochemical or toxicology studies will not be published. Papers describing the behavioral effects of novel drugs in models of psychiatric, neurological and cognitive disorders, and central pain must include a positive control unless the paper is on a disease where such a drug is not available yet. Papers focusing on physiological processes (e.g., peripheral pain mechanisms, body temperature regulation, seizure activity) are not accepted as we would like to retain the focus of Pharmacology Biochemistry & Behavior on behavior and its interaction with the biochemistry and neurochemistry of the central nervous system. Papers describing the effects of plant materials are generally not considered, unless the active ingredients are studied, the extraction method is well described, the doses tested are known, and clear and definite experimental evidence on the mechanism of action of the active ingredients is provided.
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