Delayed effects of alcohol consumption on the association between serum BDNF levels and post-traumatic stress disorder development over two-years

IF 5.3 2区 医学 Q1 CLINICAL NEUROLOGY Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2024-07-25 DOI:10.1016/j.pnpbp.2024.111106
Jae-Min Kim , Hee-Ju Kang , Ju-Wan Kim , Hyunseok Jang , Jung-Chul Kim , Ju-Yeon Lee , Sung-Wan Kim , Il-Seon Shin
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Abstract

Backgrounds

This study aimed to examine the individual and combined effects of serum BDNF (sBDNF) levels and alcohol consumption status, assessed shortly after a physical injury, on the development of post-traumatic stress disorder (PTSD) over two years.

Methods

Participants were consecutively recruited from a trauma center and followed prospectively for two years. At baseline, sBDNF levels and alcohol consumption history were assessed. A range of socio-demographic and clinical covariates were also collected. PTSD diagnosis during follow-up (3, 6, 12, and 24 months post-injury) was established using the Clinician-Administered PTSD Scale for DSM-5. Binary and multinomial logistic regression analyses were employed to investigate the relationships between sBDNF levels, alcohol consumption status, and PTSD onset.

Results

Out of 923 participants analyzed, 112 (12.1%) developed PTSD at some point during the study, with prevalence rates of 8.8% at 3 months, 7.6% at 6 months, 4.8% at 12 months, and 3.7% at 24 months. The study found no individual associations between sBDNF levels or alcohol consumption status and PTSD development. However, lower sBDNF levels significantly predicted PTSD in individuals who consumed alcohol, a relationship not observed in non-drinkers, with significant interaction terms. This pattern was consistent at later follow-up points from 12 to 24 months, but not at earlier assessments at 3 and 6 months.

Limitations

The study's reliance on participants from a single trauma center with moderate to severe injuries may limit the generalizability of the findings.

Conclusions

A significant interaction between sBDNF levels and alcohol consumption in relation to PTSD development was observed, particularly in the long term. These findings highlight the necessity of considering both sBDNF levels and alcohol consumption in strategies aimed at preventing PTSD among individuals with physical injuries, underscoring the need for tailored approaches based on these factors.

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饮酒对两年内血清 BDNF 水平与创伤后应激障碍发展之间关系的延迟影响。
背景:本研究旨在考察身体受伤后不久评估的血清BDNF(sBDNF)水平和饮酒状况在两年内对创伤后应激障碍(PTSD)发展的单独和综合影响:从创伤中心连续招募参与者,并对其进行为期两年的前瞻性跟踪调查。在基线时,对 sBDNF 水平和饮酒史进行评估。此外,还收集了一系列社会人口学和临床协变量。在随访期间(受伤后 3、6、12 和 24 个月),使用 DSM-5 临床医师管理创伤后应激障碍量表确定创伤后应激障碍诊断。采用二元和多项式逻辑回归分析来研究 sBDNF 水平、饮酒状况和创伤后应激障碍发病之间的关系:在分析的 923 名参与者中,有 112 人(12.1%)在研究期间的某个阶段患上了创伤后应激障碍,3 个月时的患病率为 8.8%,6 个月时为 7.6%,12 个月时为 4.8%,24 个月时为 3.7%。研究发现,sBDNF 水平或饮酒状况与创伤后应激障碍的发展之间没有个体关联。然而,在饮酒者中,较低的sBDNF水平可显著预测创伤后应激障碍的发生,而在非饮酒者中则未观察到这种关系,并且存在显著的交互项。这种模式在12至24个月的后期随访中是一致的,但在3个月和6个月的早期评估中并不一致:研究依赖于来自单一创伤中心的中重度伤者,这可能会限制研究结果的推广性:研究观察到,sBDNF水平和饮酒量之间存在明显的交互作用,这与创伤后应激障碍的发展有关,尤其是在长期。这些研究结果突出表明,在旨在预防肢体受伤者创伤后应激障碍的策略中,必须同时考虑sBDNF水平和酒精摄入量,并强调需要根据这些因素采取有针对性的方法。
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来源期刊
CiteScore
12.00
自引率
1.80%
发文量
153
审稿时长
56 days
期刊介绍: Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.
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