Serum immunoglobulin concentrations and risk of type 2 diabetes mellitus in adults: a prospective cohort study from the TCLSIH study.

IF 2.9 4区医学 Q3 IMMUNOLOGY BMC Immunology Pub Date : 2024-07-29 DOI:10.1186/s12865-024-00637-9

Li Zhang, Yuanbin Li, Honglei Wang, Yirui Guo, Xiaotong Wang, Hongmei Wu, Qing Zhang, Li Liu, Ge Meng, Shunming Zhang, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Anna Stubbendorff, Yeqing Gu, Kaijun Niu

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Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that inflammation played an important role in the pathogenesis of T2DM. Prospective studies on the link between immunoglobulins concentrations and the risk of T2DM in adults are limited. We developed a cohort study including 7,093 adults without T2DM history. The incidence of T2DM was 16.45 per 1,000 person-years. Compared with the lowest quartiles, the hazard ratios (95% confidence intervals) of T2DM for the highest quartiles of IgG, IgE, IgM and IgA were 0.64 (0.48-0.85), 0.94 (0.72-1.23), 0.68 (0.50-0.92) and 1.62 (1.24-2.11) (P for trend was < 0.01, 0.84, 0.02 and < 0.0001), respectively, suggesting that serum IgG and IgM concentrations were inversely associated with the incidence of T2DM, and IgA levels were positively associated with the risk of T2DM in a general adult population.

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血清免疫球蛋白浓度与成人罹患 2 型糖尿病的风险：TCLSIH 研究的前瞻性队列研究。

2 型糖尿病（T2DM）是一种代谢紊乱疾病，其特征是胰岛素分泌和/或胰岛素作用缺陷导致的高血糖。越来越多的证据表明，炎症在 T2DM 的发病机制中扮演着重要角色。有关免疫球蛋白浓度与成人 T2DM 风险之间联系的前瞻性研究十分有限。我们开展了一项队列研究，纳入了 7093 名无 T2DM 病史的成年人。T2DM 的发病率为每千人年 16.45 例。与最低四分位数相比，IgG、IgE、IgM 和 IgA 的最高四分位数的 T2DM 危险比（95% 置信区间）分别为 0.64 (0.48-0.85)、0.94 (0.72-1.23)、0.68 (0.50-0.92) 和 1.62 (1.24-2.11)。

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来源期刊

BMC Immunology 医学-免疫学

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.