Disability and Quality of Life Measures in older frail and prefrail people with type 2 diabetes. The MIDFRAIL-Study

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes research and clinical practice Pub Date : 2024-08-01 DOI:10.1016/j.diabres.2024.111797

Alan J. Sinclair , Olga Laosa , Jose Antonio Carnicero , Leocadio Rodriguez-Mañas , Alejandro Álvarez-Bustos , on behalf of the MIDFRAIL consortium

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引用次数: 0

Abstract

Aim

To explore the individual response to a multimodal intervention on quality of life (QOL) and disability.

Methods

843 (77.83 years, 50.65 % men) prefrail and frail individuals ≥ 70 years with type 2 diabetes mellitus. Participants were randomized to the usual care group (UCG) or the multicomponent intervention (IG). Intervention consisted in 16-week progressive resistance training program, 7 educational sessions and the achievement of HbA1c (7–8 %, 53–64 mmol/mol)) and BP (<150 mmHg) targets. QOL (EuroQol EQ-5D-5L), basic (Barthel Index, BI) and instrumental (Lawton and Brody Index) activities of daily living (ADL) were assessed. Multivariate binomial and multinomial logistic regression models were used to explore the effect of the IG, and adherence on the outcomes studied.

Results

The IG was associated with a significant higher probability of improvement in the QOL [OR(95 %CI): 1.75 (1.20, 2.54), p-value 0.004] and a lower probability of deterioration in QoL [0.61 (0.87, 0.54), 0.006] and Barthel Index [0.59 (0.37, 0.93), 0.023]. A high adherence (≥93 %) was needed to achieve benefits in the QOL while > 84.38 % was needed for achieving the benefits in Barthel Index.

Conclusions

IG has proven to be effective in increasing QOL and avoiding the worsening of QOL and basic ADL.

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2 型糖尿病老年体弱者和先天性体弱者的残疾和生活质量测量。MIDFRAIL-研究。

方法：843 名（77.83 岁，50.65% 为男性）年龄≥ 70 岁的 2 型糖尿病患者。参与者被随机分配到常规护理组（UCG）或多成分干预组（IG）。干预措施包括为期 16 周的渐进式阻力训练计划、7 次教育课程以及 HbA1c（7%-8%，53-64 mmol/mol）和血压（结果：IG 与 QoL 明显改善的概率[OR(95 %CI)：1.75 (1.20, 2.54)，P 值 0.004]和 QoL [0.61 (0.87, 0.54), 0.006] 及 Barthel 指数[0.59 (0.37, 0.93), 0.023]恶化的概率较低相关。要想在 QOL 方面获益，需要较高的依从性（≥93 %），而要想在 Barthel 指数方面获益，则需要 > 84.38 %：事实证明，IG 能有效提高 QOL，避免 QOL 和基本 ADL 的恶化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.