Diabetes research and clinical practice最新文献

{"title":"Achievement of guideline targets among people with type 2 diabetes with eASCVD and high risk of ASCVD in the UAE: Results of the PACT-MEA-UAE cohort","authors":"Alaaeldin Bashier ,&nbsp;Amrish Agrawal ,&nbsp;Dinesh Dhanwal ,&nbsp;Fatheya A. Awadi ,&nbsp;Ghada Awada ,&nbsp;Haitham Seifeldin ,&nbsp;Hani Sabbour ,&nbsp;Hazem Aly ,&nbsp;Hussam Abusahmin ,&nbsp;Hussien Heshmat ,&nbsp;Touseef Azhar ,&nbsp;Vani K. Warrier ,&nbsp;Wael Almahmeed","doi":"10.1016/j.diabres.2025.112030","DOIUrl":"10.1016/j.diabres.2025.112030","url":null,"abstract":"<div><h3>Aim</h3><div>The Prevalence of Atherosclerotic Cardiovascular Disease in Patients with Type 2 Diabetes across the Middle East and Africa (PACT-MEA) study compared cardiovascular disease (CVD) risk and 2021 ESC guidelines adherence between UAE and broader MEA region participants for enhanced type 2 diabetes mellitus (T2D) and atherosclerotic cardiovascular disease (ASCVD).</div></div><div><h3>Methods</h3><div>A survey of 385 physicians explored clinical decision-making factors. Chart reviews of 3726 participants classified ASCVD risk as per 2021 ESC guidelines and compared T2D target achievement in primary and secondary care centers.</div></div><div><h3>Results</h3><div>The survey highlighted factors influencing T2D management decisions, with most adhering to international guidelines. Among 542 UAE participants, 62.7 % were at high and 37.1 % at very high risk for ASCVD. Target HbA_1c was achieved 45 % UAE vs. 37 % in regionally, BP by 41 % vs. 30 %, LDL by 36 % vs. 30 %, BMI &lt;25 kg/m² by 20 % vs. 15 %, SGLT2is use by 63 % vs. 37 % and GLP-1RAs use by 22 % vs. 13 %, respectively. No participants met all ESC-recommended targets for T2D.</div></div><div><h3>Conclusion</h3><div>Physicians followed international guidelines, considering patient history, drug efficacy, and HbA1c levels for diabetes and ASCVD risks. In UAE, &lt;50 % of at-risk individuals with T2D met ESC targets. Cardioprotective medication use was higher in UAE.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112030"},"PeriodicalIF":6.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of multidisciplinary team and experience-based co-design on the care of older adult patients with type 2 diabetes: A randomized controlled trial","authors":"Yujun Zhuang ,&nbsp;Hongjiang Ye ,&nbsp;Xiaoyan Yang ,&nbsp;Lifang Zheng ,&nbsp;Zhizhen Chen ,&nbsp;Jianjia Jiang ,&nbsp;Lunpan Mou ,&nbsp;Pingping Li ,&nbsp;Jiawei Qin ,&nbsp;Yaduan Dai ,&nbsp;Yanling Mao","doi":"10.1016/j.diabres.2025.112028","DOIUrl":"10.1016/j.diabres.2025.112028","url":null,"abstract":"<div><div>This study evaluates the impact of a multidisciplinary team (MDT) approach combined with experience-based co-design (EBCD) on managing elderly patients with type 2 diabetes, focusing on glycemic control, metabolic indicators, and quality of life. A randomized controlled trial conducted from October to December 2023 included 216 hospitalized patients at Quanzhou First Hospital. Patients were randomly assigned to either the MDT-EBCD intervention or standard care group and followed for 26 weeks. Outcomes measured included BMI, fasting blood glucose (FBG), glycated hemoglobin (HbA1c), lipid profiles, renal function, and quality of life. No significant baseline differences were observed between the groups. Post-intervention, the MDT-EBCD group showed significant improvements in BMI, FBG, HbA1c, lipid profiles, and renal function (P &lt; 0.01), alongside enhanced quality of life dimensions like emotional function, vitality, and social functioning compared to the control group (P &lt; 0.05). These findings support the MDT-EBCD model as an effective framework for improving comprehensive diabetes care in the elderly.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112028"},"PeriodicalIF":6.1,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of a single bout structured resistance and combined exercise on blood glucose profile during exercise in patients with type 2 diabetes and healthy adults: A randomized crossover study","authors":"Yu-Min Huang ,&nbsp;Zijia Liu ,&nbsp;Jing Fu ,&nbsp;Peng-Fei Shan ,&nbsp;Jian Wang ,&nbsp;Xu Wen","doi":"10.1016/j.diabres.2025.112031","DOIUrl":"10.1016/j.diabres.2025.112031","url":null,"abstract":"<div><h3>Aims</h3><div>The effects of postprandial resistance and combined exercise on blood glucose profiles, particularly in patients with type 2 diabetes, remain unclear. Comprehending these responses may aid in diabetes management.</div></div><div><h3>Methods</h3><div>Three trials were conducted: trial A examined aerobic, resistance, and combined exercise; trials B and C focused on three intensities of resistance and combined exercise. Participants including patients with type 2 diabetes and healthy adults completed a randomized crossover experiment with two arrangements of three interventions and continuous glucose monitoring. Blood glucose iAUC and slope were analyzed via repeated measures two-way ANOVA.</div></div><div><h3>Results</h3><div>A total of 21 patients with type 2 diabetes (47.81±11.88 years) and 26 healthy adults (31.77±6.66 years) were assigned. In trials A–C, the main effect of subject group on iAUC/min was significant (<em>p</em>＜0.001, <em>p</em> = 0.003, and <em>p</em>＜0.001). The exercise in trial A (<em>p</em> = 0.006) and subject group in trial C (<em>p</em> = 0.005) significantly impacted the blood glucose slope.</div></div><div><h3>Conclusions</h3><div>Resistance and combined exercise reduce postprandial hyperglycemia in type 2 diabetes patients. Monitoring glucose before exercise may help prevent extreme events.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112031"},"PeriodicalIF":6.1,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise training and physical activity advice on HbA1c in people with type 2 diabetes: A network meta-analysis of randomized controlled trials.","authors":"Sheila Piccoli Garcia, Felipe Vogt Cureau, Fernando de Quadros Iorra, Leonardo G Bottino, Laura E R C Monteiro, Gabriel Leivas, Daniel Umpierre, Beatriz D Schaan","doi":"10.1016/j.diabres.2025.112027","DOIUrl":"https://doi.org/10.1016/j.diabres.2025.112027","url":null,"abstract":"<p><strong>Aims: </strong>To compare the magnitude of the benefit of different exercise modalities on glycemic control, including aerobic training (AT), resistance training (RT), combined training (CT), high-intensity interval training (HIIT) and physical activity advice.</p><p><strong>Methods: </strong>A network meta-analysis was conducted. Seven databases were searched from inception to May 2024. We included randomized clinical trials of at least 12 weeks' duration evaluating different types of physical exercise and physical activity advice to reduce HbA1c in people with type 2 diabetes.</p><p><strong>Results: </strong>158 studies (17,059 participants) were included. Compared with the control group, all types of exercise were associated with lower HbA1c: HIIT [-0.61 % (95 % CrI -0.84; -0.37)], CT [-0.58 % (95 % CrI -0.73; -0.42], AT [-0.58 % (95 % CrI -0.70; -0.45)], RT [-0.40 % (95 % CrI -0.59; -0.21)] and physical activity advice [-0.35 % (95 % CrI -0.53; -0.16)]. HIIT was the most effective treatment for HbA1c reduction (SUCRA = 82 %), followed by CT (SUCRA = 77 %), AT (SUCRA = 76 %), RT (SUCRA = 37 %) and physical activity advice (SUCRA = 29 %).</p><p><strong>Conclusions: </strong>HIIT was associated with the greatest reduction in HbA1c. Physical activity advice, which is easy to implement, accessible and unsupervised, should also be offered to people with type 2 diabetes to improve glycemic control.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"112027"},"PeriodicalIF":6.1,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing obesity in adults with type 1 diabetes","authors":"Alejandro Campos ,&nbsp;Rene Rivera Gutierrez ,&nbsp;Rodolfo J. Galindo ,&nbsp;Rozalina G. McCoy ,&nbsp;Maria D. Hurtado Andrade","doi":"10.1016/j.diabres.2024.111983","DOIUrl":"10.1016/j.diabres.2024.111983","url":null,"abstract":"<div><div>As the prevalence of obesity has reached epidemic proportions, its prevalence has also increased among adults living with type 1 diabetes mellitus. Unlike the pathophysiologic relationship between obesity and type 2 diabetes mellitus, the relationship between obesity and type 1 diabetes mellitus, and management of obesity in the setting of type 1 diabetes mellitus, have not been well reviewed. In this article, we discuss the comprehensive management of obesity in adults with type 1 diabetes mellitus, focusing on medical nutrition therapy and adjunct therapies such as weight loss-promoting medications and metabolic/bariatric surgery.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111983"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowerment in Type 2 diabetes: A patient-centred approach for lifestyle change","authors":"Charlotte Björk Ingul ,&nbsp;Siri Marte Hollekim-Strand ,&nbsp;Mari Mørkeset Sandbakk ,&nbsp;Torunn Ingfrid Grønseth ,&nbsp;Tone Iren K. Rånes ,&nbsp;Lars Tung Dyrendahl ,&nbsp;Katarina Eilertsen ,&nbsp;Stephan Kristensen ,&nbsp;Turid Follestad ,&nbsp;Bjarte Bye Løfaldli","doi":"10.1016/j.diabres.2025.111998","DOIUrl":"10.1016/j.diabres.2025.111998","url":null,"abstract":"<div><h3>Aims</h3><div>To evaluate the effectiveness of personalized lifestyle intervention service for persons with Type 2 diabetes (T2D), implemented in a real-world setting at two Healthy Life Centers (HLC) in Norway.</div></div><div><h3>Methods</h3><div>Persons with T2D were randomized into either an HLC intervention group or a usual care group for 12 weeks. All participants were screened using a questionnaire tool and had one initial patient-centred health conversation at the HLC. In the intervention group, participants chose interventions with support from HLC staff. The usual care group continued independently. Outcome variables were assessed at baseline, 12 weeks, and 24 weeks (if completing two interventions).</div></div><div><h3>Results</h3><div>110 participants were included (mean age 59.9, 59 % T2D duration &lt; 10 years, 36 % females). There was no significant difference in HbA1c change between intervention and usual care groups (mean difference −1.2 mmol/l, 95 % CI: −3.7 to 1.3, p = 0.33). HbA1c was significantly reduced in both groups (mean reduction 3.8 mmol/l (95 % CI: 2.1 to 5.5, p &lt; 0.001) vs. 2.6 mmol/l (95 % CI: 0.7 to 4.4, p = 0.006), respectively).</div></div><div><h3>Conclusions</h3><div>Both the HLC personalized follow-up and usual care groups reduced HbA1c with no significant differences between groups. This suggests that low-threshold municipal healthcare can effectively support lifestyle changes in individuals with T2D.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111998"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of silymarin on insulin resistance and sensitivity: A systematic review and meta-analysis of randomized controlled trials","authors":"Shao Yin ,&nbsp;Fengya Zhu ,&nbsp;Ying Liu ,&nbsp;Qiu Chen","doi":"10.1016/j.diabres.2025.112008","DOIUrl":"10.1016/j.diabres.2025.112008","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate the effect of silymarin on insulin resistance and insulin sensitivity through a systematic review and meta-analysis of randomized controlled trials (RCTs).</div></div><div><h3>Methods</h3><div>We searched PubMed, Embase, Web of Science, and Cochrane Library up to September 2024 for relevant RCTs. The intervention required silymarin supplementation for at least 4 weeks. Primary outcomes were homeostatic model assessment of insulin resistance (HOMA-IR) and fasting insulin (FI), while secondary outcomes included quantitative insulin sensitivity check index (QUICKI). Bias risk was assessed using Cochrane RoB 2. Subgroup analyses were based on disease type, duration, and dosage. Sensitivity and publication bias analyses were conducted using Egger’s and Begg’s tests. Statistical analysis and meta-analysis were performed using Stata 15.1.</div></div><div><h3>Results</h3><div>Six studies with 673 participants from Iran, Egypt, and Italy were included. All studies had low risk of bias. Meta-analysis showed that Silybum marianum significantly improved HOMA-IR (WMD = −2.29, 95 % CI: −4.55 to −0.03, p = 0.047) but had no effect on FI (WMD = −2.56, 95 % CI: −7.60 to 2.48, p = 0.862). Subgroup analyses revealed improvements in HOMA-IR for T2DM and diabetics with alcoholic cirrhosis, but no effect in non-alcoholic fatty liver disease (NAFLD) patients. QUICKI did not show significant changes in any group. Only one study reported changes in QUICKI. The results indicated that, compared to the placebo, silymarin improved insulin sensitivity in patients with type 2 diabetes mellitus (T2DM).</div></div><div><h3>Conclusion</h3><div>In conclusion, the results of this study indicate that there is limited evidence supporting the effectiveness of silymarin in improving HOMA-IR and FI levels in metabolic diseases, and it generally does not appear to significantly improve these parameters. Future studies should aim to increase the number of high-quality RCTs to further validate the efficacy and safety of silymarin, as well as to explore its underlying mechanisms.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 112008"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 diabetes incidence curves differ by age for girls and boys between 1996 and 2022: Results from the North Rhine-Westphalia Diabetes Registry, Germany","authors":"Anna Stahl-Pehe ,&nbsp;Christina Baechle ,&nbsp;Stefanie Lanzinger ,&nbsp;Michael S. Urschitz ,&nbsp;Reinhard W. Holl ,&nbsp;Joachim Rosenbauer","doi":"10.1016/j.diabres.2025.111996","DOIUrl":"10.1016/j.diabres.2025.111996","url":null,"abstract":"<div><div>The type 1 diabetes incidence was analyzed in 0- to 14-year-old children in North Rhine-Westphalia, Germany, from 1996 to 2022. The data revealed an overall increasing trend, with variations by age and sex. The incidence increased in boys across age groups but peaked in girls in the 5–9-year age group.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111996"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic foot: A systematic review and meta-analysis on its prevalence and associated factors among patients with diabetes mellitus in a sub-Saharan Africa","authors":"Kirubel Eshetu Haile ,&nbsp;Yordanos Sisay Asgedom ,&nbsp;Gedion Asnake Azeze ,&nbsp;Atitegeb Alebachew Amsalu ,&nbsp;Amanuel Yosef Gebrekidan ,&nbsp;Gizachew Ambaw Kassie","doi":"10.1016/j.diabres.2024.111975","DOIUrl":"10.1016/j.diabres.2024.111975","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes is one of the non-communicable diseases that represents the greatest public health challenge in sub-Saharan Africa, where diabetes related needs are currently largely unmet, and the debilitating aspects of the foot are worsened by issues related to healthcare costs, self-care practices, and inadequate knowledge. To estimate the pooled prevalence and associated factors of diabetic foot ulcers among patients with Diabetes mellitus, we conducted a systematic review and <em>meta</em>-analysis. Although studies on, diabetic foot ulcer among patients with diabetes mellitus have been available, the results have been inconsistent.</div></div><div><h3>Objectives</h3><div>To determine the pooled prevalence and associated factors of diabetic foot ulcers among patients with diabetes mellitus in sub-Saharan Africa.</div></div><div><h3>Methods</h3><div>A systematic review and <em>meta</em>-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. To identify papers published in English up to May 29, 2024, the electronic databases of Medline, Science Direct, Excerpta Medica Database, Cochrane Library, African Journals Online, and Google Scholar were searched. The DerSimonian and Laird method for random-effects models was used to estimate the pooled prevalence of diabetic foot ulcers. To test for heterogeneity between studies and publication bias, forest plots and funnel plots were, respectively used.</div></div><div><h3>Results</h3><div>A total of 28 studies with 10,635 participants were included in this systematic review and <em>meta</em>-analysis. The pooled prevalence of diabetic foot ulcer among patients with diabetes mellitus was 13.35 % (95 % CI 10.86, 15.67). Rural residence (OR = 3.25, 95 % CI = 2.15–4.99), peripheral neuropathy (OR = 5.89, 95 % CI = 2.5–13.5), poor self-care practice (OR = 2.39, 95 % CI = 1.12–5.13), illness duration greater than 10 years (OR = 2.94, 95 % CI = 1.14, 7.63), and history of ulcer (OR = 6.07, 95 % CI = 1.68–21.9) were significantly associated with diabetic foot ulcers.</div></div><div><h3>Conclusion</h3><div>Sub-Saharan Africa has a high prevalence of diabetic foot ulcers. Thus, emphasis should be given to Prevention, periodic foot examination, and early identification of risk factors.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111975"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery and exploration of adaptive immune response-related drug targets in diabetic retinopathy by Mendelian randomization","authors":"Ning Gao,&nbsp;Jingming Li,&nbsp;Ting Wei,&nbsp;Qiaochu Cheng,&nbsp;Shan Gao,&nbsp;Yaguang Hu","doi":"10.1016/j.diabres.2025.111987","DOIUrl":"10.1016/j.diabres.2025.111987","url":null,"abstract":"<div><h3>Background</h3><div>Persistent diabetes raises diabetic retinopathy (DR) risk, and management is challenging. Integrating transcriptomics and MR, this study provides a current reference for the clinical treatment of DR by identifying potential drug targets in adaptive immune response-associated genes (AIR-RGs).</div></div><div><h3>Methods</h3><div>The GSE102485 dataset about AIR-RGs and DR was downloaded from a public database. Initially, the MR and Steiger test identified AIR-related candidate genes with causal associations to DR. Bayesian co-localization analysis pinpointed DR drug targets, followed by phenotype scanning for side effects. Functional enrichment and immune infiltration analyses elucidated target mechanisms in DR.</div></div><div><h3>Results</h3><div>Identified 27 AIR-RGs associated with DR, with <em>TRAV23DV6</em> (OR = 1.367, 95 % CI = 1.005–1.859, p = 0.0046) as a risk factor. Co-localization analysis confirmed <em>TRAV23DV6</em>′s potential as a DR drug target. Phenotype scanning linked <em>TRAV23DV6</em> to hepatocellular carcinoma, thromboembolism, and pyelonephritis, indicating potential side effects. <em>TRAV23DV6</em> engages in adaptive immunity, autophagy, and antigen binding. DR involves infiltration of 22 immune cell types and activation of 16 immune functions related to TCR, BCR pathways, and TNF family. Correlation analysis shows high <em>TRAV23DV6</em> expression, immune cell infiltration, and function activation may exacerbate DR.</div></div><div><h3>Conclusion</h3><div><em>TRAV23DV6</em> has been identified as a potential drug target for DR, offering a new perspective for the treatment of this condition.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111987"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}