The efficacy and safety of complementary and alternative medicine for depression: an umbrella review.

IF 3.6 3区医学 Q1 PSYCHIATRY Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI:10.47626/1516-4446-2024-3705

Yiting Liu, Rongfei Yang, Nana Zhang, Qingshan Liu

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Abstract

Objective: Depression is a major public health problem. Many complementary and alternative medicine (CAM) interventions have been suggested as potential treatments. This umbrella review aimed to assess the efficacy and safety of CAM interventions for treating depression.

Methods: We comprehensively searched for relevant systematic reviews and meta-analyses in the MEDLINE (via PubMed), EMBASE, Web of Science, and Cochrane Library databases. We assessed effectiveness (based on efficacy and changes in depression assessment scale scores) and safety (based on adverse events).

Results: A total of 22 eligible articles were included. Yueju antidepressant and electro-acupuncture (EA) improved depression symptoms better than conventional antidepressants. In addition, omega-3 fatty acids (n-3PUFAs), exercise, manual acupuncture (MA), Hypericum mono-preparations, relaxation, and vitamin D showed superior efficacy to placebo and controls. Guipi decotion (GPD) as adjunctive therapy has higher efficacy than conventional antidepressants, and MA and Yueju have a better safety profile than conventional antidepressants.

Conclusion: 10 CAMs can effectively improve the condition of patients with clinical depression.

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补充和替代医学治疗抑郁症的有效性和安全性：综述》。

目的：抑郁症是一个重大的公共卫生问题。许多补充和替代医学（CAM）干预措施被建议作为潜在的治疗方法：我们在 PubMed、EMBASE、Web of Science 和 Cochrane Library 数据库中全面检索了相关的系统综述和荟萃分析。我们根据效率和抑郁评估量表评分的变化来评估有效性，并根据不良事件来评估安全性：本综述共纳入了 22 篇符合条件的文章。越剧抗抑郁药和电针（EA）对抑郁症状的改善效果优于抗抑郁药。此外，ω-3 脂肪酸（n-3PUFAs）、运动、手工针灸（MA）、金丝桃单方制剂、放松和维生素 D 的疗效优于安慰剂和对照组。GPD作为辅助疗法的有效率高于抗抑郁药，而MA和越剧抗抑郁药的安全性优于抗抑郁药：我们的研究表明，10 种 CAMs 可有效改善临床抑郁症患者的病情。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Brasileira de Psiquiatria 医学-精神病学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.