Longitudinal Gut Microbiota Composition During Perinatal period in Women with Different Intensities of Depressive Symptoms.

IF 3.6 3区 医学 Q1 PSYCHIATRY Revista Brasileira de Psiquiatria Pub Date : 2024-09-21 DOI:10.47626/1516-4446-2024-3721
Amanda S Mota, Luiz Gustavo Sparvoli, Pedro Augusto R Vanzele, Nathalia F Naspolini, Eric de Castro Tobaruela, Carlos T Yoshizaki, Rossana Pulcineli Vieira Francisco, Ana Maria S S Oliveira, Marco Aurélio Knippel Galletta, Vera Lucia C Tess, Carla R Taddei
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引用次数: 0

Abstract

Background: Depressive symptoms during perinatal significantly impact mothers and infants. Emerging evidence suggests a connection between gut microbiota and mood regulation. This study investigated whether depressive symptoms are associated with changes in the gut microbiota of women during the perinatal period.

Method: A total of 34 pregnant women were screened for depression using the Edinburgh Postnatal Depression Scale (EPDS) and categorized based on symptom severity. Stool samples were collected during the third trimester and at two postpartum timepoints. All samples underwent 16S rRNA gene sequencing and Quantification of Short-Chain Fatty Acids (SCFA) using a gas chromatograph-mass spectrometer (GC-MS).

Results: No differences in SCFA concentrations were observed between groups (p>0.05). However, postpartum women with moderate to severe symptoms (MG group) had a significant increase in Enterobacteriaceae abundance compared to the mild and absent group (AL group) (p<0.05). The Bifidobacterium genus increased significantly in both groups over time (p<0.05). The MG group showed a reduction in depressive symptoms during psychiatric treatment (p<0.05).

Conclusion: These findings suggest a link between gut microbiota and perinatal depressive symptoms. Further research is needed to understand the broader implications for maternal health through microbiome-targeted approaches.

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不同抑郁症状强度妇女围产期的纵向肠道微生物群组成
背景:围产期抑郁症状对母亲和婴儿都有重大影响。新的证据表明,肠道微生物群与情绪调节之间存在联系。本研究调查了抑郁症状是否与围产期妇女肠道微生物群的变化有关:方法:使用爱丁堡产后抑郁量表(EPDS)对 34 名孕妇进行抑郁筛查,并根据症状严重程度进行分类。在怀孕三个月和产后两个时间点收集粪便样本。所有样本都进行了 16S rRNA 基因测序,并使用气相色谱-质谱仪(GC-MS)对短链脂肪酸(SCFA)进行了定量:各组间的 SCFA 浓度无差异(P>0.05)。然而,与轻度和无症状组(AL 组)相比,有中度至重度症状的产后妇女(MG 组)的肠杆菌科细菌数量显著增加(p):这些研究结果表明,肠道微生物群与围产期抑郁症状之间存在联系。还需要进一步研究,以了解微生物组靶向方法对孕产妇健康的广泛影响。
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来源期刊
Revista Brasileira de Psiquiatria
Revista Brasileira de Psiquiatria 医学-精神病学
CiteScore
6.60
自引率
0.00%
发文量
83
审稿时长
6-12 weeks
期刊介绍: The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.
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