{"title":"Magnetic resonance imaging of the breast: Could it be used as a screening test?","authors":"Deema A Nagadi, Naglaa M Elsayed","doi":"10.15537/smj.2024.45.8.20230748","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To investigate whether magnetic resonance imaging (MRI) best detects early malignancy in high-risk women.</p><p><strong>Methods: </strong>A retrospective, cross-sectional study, carried out at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, included 419 female breast cancer patients aged 16-84 years (mean age of 49). Data were collected from the radiological department's database to compare the MRI, ultrasound (US), and mammography results, with or without tissue biopsy.</p><p><strong>Results: </strong>In diagnosing benign versus malignant lesions, MRI showed significant agreement with tissue biopsy, with high sensitivity (70%) and specificity (87%); its positive predictive value (PPV) was 92% and negative predictive value (NPV) was 56%. While US has a PPV of 84% and NPV of 63%; with a sensitivity (79%) and specificity (71%). In patients without tissue biopsy, there was little difference between mammography and US compared with MRI results.</p><p><strong>Conclusion: </strong>Magnetic resonance imaging is more effective than US and mammography for early detection of BC. It showed high sensitivity in detecting breast lesions and high specificity in characterizing their nature when correlated with pathological results. Ultrasound screening followed by MRI is suggested for undetected or suspected lesions. This will increase the breast lesion detection rate, reduce unneeded tissue biopsies, and enhance the disease's survival rate.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288493/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saudi Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.15537/smj.2024.45.8.20230748","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: To investigate whether magnetic resonance imaging (MRI) best detects early malignancy in high-risk women.
Methods: A retrospective, cross-sectional study, carried out at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, included 419 female breast cancer patients aged 16-84 years (mean age of 49). Data were collected from the radiological department's database to compare the MRI, ultrasound (US), and mammography results, with or without tissue biopsy.
Results: In diagnosing benign versus malignant lesions, MRI showed significant agreement with tissue biopsy, with high sensitivity (70%) and specificity (87%); its positive predictive value (PPV) was 92% and negative predictive value (NPV) was 56%. While US has a PPV of 84% and NPV of 63%; with a sensitivity (79%) and specificity (71%). In patients without tissue biopsy, there was little difference between mammography and US compared with MRI results.
Conclusion: Magnetic resonance imaging is more effective than US and mammography for early detection of BC. It showed high sensitivity in detecting breast lesions and high specificity in characterizing their nature when correlated with pathological results. Ultrasound screening followed by MRI is suggested for undetected or suspected lesions. This will increase the breast lesion detection rate, reduce unneeded tissue biopsies, and enhance the disease's survival rate.
目的:研究磁共振成像(MRI)是否是检测高危妇女早期恶性肿瘤的最佳方法:研究磁共振成像(MRI)是否最能检测出高风险女性的早期恶性肿瘤:沙特阿拉伯吉达市阿卜杜勒-阿齐兹国王大学医院开展了一项回顾性横断面研究,纳入了 419 名年龄在 16-84 岁(平均年龄 49 岁)的女性乳腺癌患者。研究人员从放射科数据库中收集数据,比较核磁共振成像(MRI)、超声波(US)和乳腺X光检查(有无组织活检)的结果:结果:在诊断良性病变与恶性病变时,核磁共振成像与组织活检结果显示出明显的一致性,具有较高的灵敏度(70%)和特异性(87%);其阳性预测值(PPV)为 92%,阴性预测值(NPV)为 56%。而 US 的 PPV 为 84%,NPV 为 63%;灵敏度(79%)和特异性(71%)均较高。在没有进行组织活检的患者中,乳腺 X 光检查和 US 与磁共振成像结果相比差别不大:结论:磁共振成像在早期发现乳腺癌方面比 US 和乳房 X 光检查更有效。结论:磁共振成像比 US 和乳腺 X 光检查更能有效地早期发现 BC,它在检测乳腺病变方面显示出较高的灵敏度,在与病理结果相关联时,在确定病变性质方面显示出较高的特异性。建议对未发现或疑似病变的患者先进行超声波筛查,然后再进行磁共振成像检查。这将提高乳腺病变的检出率,减少不必要的组织活检,提高疾病的存活率。
期刊介绍:
The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license.
The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.