Effects of Antioxidant Dietary Supplement Use upon Response to Cancer Treatment: A Scoping Review of Available Evidence.

IF 2 4区医学 Q3 NUTRITION & DIETETICS Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-07-30 DOI:10.1080/01635581.2024.2385167

L Susan Wieland, Sydney Shade, Ilana Moffet, Amir Ansari, Ashkan Emadi, Cheryl L Knott, Emily F Gorman, Christopher R D'Adamo

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Abstract

Introduction: The effects of antioxidant dietary supplements on response to biological therapies for cancer is unknown. We conducted a scoping review of the available systematic review evidence on this question.

Methods and analysis: We searched six databases from inception to August 19, 2022 for systematic reviews of randomized controlled trials of antioxidant dietary supplements used by patients receiving curative chemotherapy, radiotherapy, or other biological therapy for cancer and assessing the impact of supplements on survival, treatment response, or disease progression. We focused on results from reviews at high or moderate AMSTAR-2 quality. Records were selected, data extracted, and AMSTAR-2 ratings assessed independently by two authors.

Results: We found 24 systematic reviews with relevant evidence. Reviews were heterogenous in cancers, treatments, and antioxidant dietary supplements assessed. Conclusions across reviews were mixed, ranging from negative to no apparent difference to positive, but always with caveats about the limited size and quality of the evidence. One review was rated 'moderate' on AMSTAR-2; it included one small trial of vitamin C and formed no firm conclusions.

Conclusions: We did not find reliable systematic review evidence on the effects of antioxidant dietary supplements upon therapies for cancer. More research is necessary to inform clinical recommendations.

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使用抗氧化剂膳食补充剂对癌症治疗反应的影响：现有证据范围综述》。

简介：抗氧化剂膳食补充剂对癌症生物疗法反应的影响尚不清楚：抗氧化剂膳食补充剂对癌症生物疗法反应的影响尚不清楚。我们就这一问题对现有的系统综述证据进行了范围界定：我们检索了六个数据库，检索时间从开始到 2022 年 8 月 19 日，检索对象为接受根治性化疗、放疗或其他癌症生物疗法的患者使用的抗氧化剂膳食补充剂，以及评估补充剂对生存、治疗反应或疾病进展的影响的随机对照试验的系统综述。我们重点关注 AMSTAR-2 高质量或中等质量的综述结果。由两位作者独立选择记录、提取数据并评估 AMSTAR-2 评级：结果：我们发现了 24 篇具有相关证据的系统综述。在所评估的癌症、治疗方法和抗氧化膳食补充剂方面，综述各不相同。各篇综述的结论不一，有否定的、无明显差异的，也有肯定的，但都有关于证据规模和质量有限的说明。有一篇综述在AMSTAR-2中被评为 "中等"；其中包括一项关于维生素C的小型试验，但没有形成明确的结论：我们没有找到关于抗氧化剂膳食补充剂对癌症治疗效果的可靠系统综述证据。有必要开展更多研究，为临床建议提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.