Inhaled Interferon for Asthma Treatment (NR): A narrative review

Abstract

Although various therapeutic strategies, such as inhalant beta-2 agonists, corticosteroids, anti-leukotrienes, and even novel inclusion of active biological agents in the management of asthma have been established, as asthma is a global issue and chronic in nature, the search for potential new tools to the arsenal continues to this day. Remarkable progress has recently been achieved in identifying the pathophysiology and potential value of interferons (IFNs) in managing allergic asthma. This narrative review attempts to precisely demonstrate the possible use of inhalant IFNs in differing asthmatic conditions by simplifying and concluding studies published between 1995 and 2021. Review findings indicate that IFN lambda and gamma could be utilized as primary tools in asthma management, while IFN beta can be used as an adjuvant therapy for viral-induced severe asthmatic exacerbations.