Comparative Pharmacokinetics Study of the Leutragin Peptide Drug in Svetlogorsk Minipig Blood Serum after Single Administration

N. S. Ogneva, M. S. Nesterov, D. Khvostov, N. V. Stankova, V. Karkischenko
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Abstract

In this work, we investigate the pharmacokinetics of a new anti-inflammatory hexapeptide registered under the name of Leutragin. The study was conducted on Svetlogorsk minipigs by intravenous and a single rectal administration of the drug in the form of a solution and suppositories at an equal dose of 10 mg. The shortest time to reach peak concentration was demonstrated with intravenous administration, with the Tmax being 30 min. The maximum concentration (Cmax) when administering Leutragin in a suppository form was 141.37 ng/g. This concentration was achieved at the Tmax of 90 min, following which Leutragin remained in the bloodstream for 2.5 h. The absolute bioavailability of Leutragin in the suppository and solution form was 59.6% and 70.03%, respectively. The peak concentration of Leutragin under its rectal administration occurred at 150 min, following with the drug remained in the bloodstream for 4 h.
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单次给药后 Svetlogorsk 迷你猪血清中 Leutragin 肽类药物的药代动力学比较研究
在这项工作中,我们研究了一种以 Leutragin 名称注册的新型抗炎六肽的药代动力学。研究以斯维特洛格斯克小型猪为研究对象,通过静脉注射和一次直肠给药的方式,分别以溶液和栓剂的形式给药,剂量相同,均为 10 毫克。静脉注射达到峰值浓度的时间最短,Tmax 为 30 分钟。以栓剂形式给药时,Leutragin 的最大浓度(Cmax)为 141.37 纳克/克。栓剂和溶液形式的亮丙瑞金的绝对生物利用度分别为 59.6% 和 70.03%。在直肠给药的情况下,Leutragin 的峰值浓度出现在 150 分钟后,随后药物在血液中停留了 4 小时。
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