Formulation and evaluation of Metoprolol succinate buccal tablets in hypertension treatment

Abstract

The research aims to formulate and evaluate the Metoprolol succinate buccal tablets in hypertension treatment. The Fourier transform infrared (FTIR) results depict no incompatibility between the drug and excipients. The study results of pre-compression parameters have excellent flow qualities and compressibility. The post-compression parameters show that the results are within the specified standard deviations. The swelling index reveals that the formulation F6 shows that the complete drug was released and the tablet integrity was maintained during the expected duration. Formulation F6 chitosan and Carbopol 934 were used in a ratio of 1:1, resulting in the release of the drug up to the 10th hour and completely. Therefore, formulation F6 was optimized and compared with the marketed product. Formulation F6 exhibited better drug release performance than the marketed product.