ALTERNATIVE THERAPIES FOR OXIDATIVE STRESS

{"title":"ALTERNATIVE THERAPIES FOR OXIDATIVE STRESS","authors":"","doi":"10.46344/jbino.2024.v13i03.07","DOIUrl":null,"url":null,"abstract":"Free radicals such as reactive oxygen species (ROS) induce oxidative stress and cause cellular damage due to lipid peroxidation. There are three important steps in lipid peroxidation, namely initiation, propagation and termination. Formation of reactive aldehydes such as MDA and 4-HNE takes place when there is a catabolism of lipid hydroperoxides. Hyperlipidemia especially LDL-cholesterol may lead to development of coronary artery disease causing morbidity or mortality due to cardiac arrhythmias. Conventional hypolipidemic drugs have unwanted effects. Herbal therapy for Hyperlipidemia is getting attention due to their less frequent side effects. In this study we have compared hypolipidemic effects of Gemfibrozil with Nigella sativa. Seventy five hyperlipidemic patients from Jinnah Hospital Lahore were enrolled for study. After getting consent all patients were divided in three groups comprising 25 patients in each group. Group 1 was on Nigella sativa, group 2 was on Gemfibrozil and third group was on placebo therapy. They were advised to take drugs for two months. After completion of study pretreatment and post treatment values of LDL cholesterol were analyzed statistically. In Nigella sativa group LDL cholesterol decreased from 191.14±3.45 to 159.40±2.98 mg/dl, means 31.7 mg/dl LDL reduction was observed when compared with placebo group. In Gemfibrozil group of patients LDL cholesterol decreased from 197.77±3.91 mg/dl to 159.62±2.20 mg/dl, means LDL reduction in mean values was 38.2 mg/dl, when compared with placebo group. These changes are highly significant with p-values of <0.001. We concluded from this study that alternative therapy by herbal medication is as effective as by allopathic medication. Key words: serum lipids, oxidative stress, lethality, toxicity.","PeriodicalId":228982,"journal":{"name":"Journal of Bio Innovation","volume":"34 S135","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bio Innovation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46344/jbino.2024.v13i03.07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Free radicals such as reactive oxygen species (ROS) induce oxidative stress and cause cellular damage due to lipid peroxidation. There are three important steps in lipid peroxidation, namely initiation, propagation and termination. Formation of reactive aldehydes such as MDA and 4-HNE takes place when there is a catabolism of lipid hydroperoxides. Hyperlipidemia especially LDL-cholesterol may lead to development of coronary artery disease causing morbidity or mortality due to cardiac arrhythmias. Conventional hypolipidemic drugs have unwanted effects. Herbal therapy for Hyperlipidemia is getting attention due to their less frequent side effects. In this study we have compared hypolipidemic effects of Gemfibrozil with Nigella sativa. Seventy five hyperlipidemic patients from Jinnah Hospital Lahore were enrolled for study. After getting consent all patients were divided in three groups comprising 25 patients in each group. Group 1 was on Nigella sativa, group 2 was on Gemfibrozil and third group was on placebo therapy. They were advised to take drugs for two months. After completion of study pretreatment and post treatment values of LDL cholesterol were analyzed statistically. In Nigella sativa group LDL cholesterol decreased from 191.14±3.45 to 159.40±2.98 mg/dl, means 31.7 mg/dl LDL reduction was observed when compared with placebo group. In Gemfibrozil group of patients LDL cholesterol decreased from 197.77±3.91 mg/dl to 159.62±2.20 mg/dl, means LDL reduction in mean values was 38.2 mg/dl, when compared with placebo group. These changes are highly significant with p-values of <0.001. We concluded from this study that alternative therapy by herbal medication is as effective as by allopathic medication. Key words: serum lipids, oxidative stress, lethality, toxicity.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
氧化应激的替代疗法
活性氧(ROS)等自由基会诱发氧化应激,并导致细胞因脂质过氧化而受损。脂质过氧化有三个重要步骤,即启动、传播和终止。当脂质氢过氧化物发生分解时,会形成活性醛,如 MDA 和 4-HNE。高脂血症,尤其是低密度脂蛋白胆固醇,可导致冠状动脉疾病的发生,并因心律失常而导致发病或死亡。传统的降脂药物会产生不良反应。治疗高脂血症的草药疗法因其副作用较小而受到关注。在这项研究中,我们比较了吉非罗齐和黑麦草的降脂效果。来自拉合尔真纳医院的 75 名高脂血症患者参与了研究。在征得同意后,所有患者被分为三组,每组 25 人。第一组服用尼加拉草,第二组服用吉非罗齐,第三组服用安慰剂。建议他们服药两个月。研究结束后,对治疗前和治疗后的低密度脂蛋白胆固醇值进行了统计分析。黑麦草组的低密度脂蛋白胆固醇从 191.14±3.45 毫克/分升降至 159.40±2.98 毫克/分升,与安慰剂组相比,低密度脂蛋白胆固醇降低了 31.7 毫克/分升。与安慰剂组相比,吉非罗齐组患者的低密度脂蛋白胆固醇从 197.77±3.91 mg/dl 降至 159.62±2.20 mg/dl,即低密度脂蛋白平均值降低了 38.2 mg/dl。这些变化非常明显,P 值均小于 0.001。我们从这项研究中得出结论,中药替代疗法与对抗疗法同样有效。关键词:血清脂质、氧化应激、致死率、毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
OVERVIEW OF ANEMIA AFTER SCOLIOSIS SURGERY IN THE INTENSIVE CARE UNIT (ICU) SOEHARSO ORTHOPEDIC HOSPITALINDONESIA EFFECT OF VERONIAAMYGDALINA ON THE ACTIVITIES OF HEPATIC ENZYMES IN WISTAR ALBINO RAT FED WITH CRUDE OIL CONTAMINATED DIET PATIENT SAFETY GOALS, AFRICA: DEVELOPMENT OF A CONTEXT FITTING TOOL FOR PATIENT SAFETY AND CARE QUALITY ASSESSMENT IN AFRICA USING THE DECIDE(HUMAN FACTORS) MODEL. IS THERE ANY RELATIONSHIP BETWEEN HUMAN BODY WEIGHT AND URINE NITRITE ALTERNATIVE THERAPIES FOR OXIDATIVE STRESS
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1